HK1149555A1 - Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands - Google Patents

Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands

Info

Publication number
HK1149555A1
HK1149555A1 HK11103741.3A HK11103741A HK1149555A1 HK 1149555 A1 HK1149555 A1 HK 1149555A1 HK 11103741 A HK11103741 A HK 11103741A HK 1149555 A1 HK1149555 A1 HK 1149555A1
Authority
HK
Hong Kong
Prior art keywords
histamine
receptor ligands
piperidine derivatives
substituted spirocyclic
spirocyclic piperidine
Prior art date
Application number
HK11103741.3A
Other languages
English (en)
Inventor
Edward R Bacon
Reddeppareddy Dandu
Lisa Guise-Zawacki
Chia-Yu Huang
Robert L Hudkins
Ming Tao
Original Assignee
Cephalon Inc
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc, Pharmacopeia Inc filed Critical Cephalon Inc
Publication of HK1149555A1 publication Critical patent/HK1149555A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
HK11103741.3A 2008-01-30 2011-04-13 Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands HK1149555A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6290708P 2008-01-30 2008-01-30
PCT/US2009/032709 WO2009097567A1 (en) 2008-01-30 2009-01-30 Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands

Publications (1)

Publication Number Publication Date
HK1149555A1 true HK1149555A1 (en) 2011-10-07

Family

ID=40626933

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11103741.3A HK1149555A1 (en) 2008-01-30 2011-04-13 Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands

Country Status (8)

Country Link
US (1) US8513232B2 (xx)
EP (1) EP2250176B1 (xx)
JP (1) JP5524083B2 (xx)
CA (1) CA2712897A1 (xx)
ES (1) ES2390004T3 (xx)
HK (1) HK1149555A1 (xx)
MX (1) MX2010008375A (xx)
WO (1) WO2009097567A1 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008013838A2 (en) * 2006-07-25 2008-01-31 Cephalon, Inc. Pyridizinone derivatives
MX2010008384A (es) 2008-01-30 2010-11-30 Cephalon Inc Derivados de piridazina substituida, con actividad antagonista de h3 de histamina.
MX2010008375A (es) 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).
WO2009142732A2 (en) * 2008-05-20 2009-11-26 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
ES2475945T3 (es) 2009-06-26 2014-07-11 Novartis Ag Derivados imidazolidin-2 -ona 1,3-disustituida como inhibidores de CYP 17
US20120190701A1 (en) * 2009-08-18 2012-07-26 Merck Sharp & Dohme Corp. Renin inhibitors
EP2488530A4 (en) * 2009-10-13 2014-03-19 Merck Canada Inc INHIBITORS OF THE RENIN
TWI543984B (zh) 2010-07-09 2016-08-01 艾伯維公司 作為s1p調節劑的螺-哌啶衍生物
TWI522361B (zh) 2010-07-09 2016-02-21 艾伯維公司 作為s1p調節劑的稠合雜環衍生物
TW201206893A (en) 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
ES2656218T3 (es) 2011-04-28 2018-02-26 Novartis Ag Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CA2927567C (en) 2013-10-18 2022-04-26 Celgene Quanticel Research, Inc. Bromodomain inhibitors
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
WO2017184462A1 (en) 2016-04-18 2017-10-26 Celgene Quanticel Research, Inc. Therapeutic compounds
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
WO2018083171A1 (en) * 2016-11-02 2018-05-11 AbbVie Deutschland GmbH & Co. KG Spiro-compounds as s1p modulators
US11046707B2 (en) 2016-12-14 2021-06-29 89Bio Ltd Spiropiperidine derivatives
WO2021087299A1 (en) 2019-10-31 2021-05-06 E-Scape Bio, Inc. Solid forms of an s1p-receptor modulator
GB201917101D0 (en) 2019-11-25 2020-01-08 Uea Enterprises Ltd Method for digesting nucleic acid in a sample

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
CA2419036A1 (en) 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
US20050148650A1 (en) * 2002-03-01 2005-07-07 Shigenori Ohkawa Antidepressant
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
EP1642898B1 (en) 2003-06-27 2013-03-27 Msd K.K. Heteroaryloxy nitrogenous saturated heterocyclic derivative
CN100418948C (zh) 2003-07-15 2008-09-17 麦克公司 羟基吡啶cgrp受体抗拮抗剂
NZ546834A (en) * 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
SE0403160D0 (sv) 2004-12-23 2004-12-23 Biovitrum Ab New compounds
US7790720B2 (en) 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
EP1707203A1 (en) 2005-04-01 2006-10-04 Bioprojet Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands
EP1717235A3 (en) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
WO2007063385A2 (en) * 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
WO2007088462A1 (en) * 2006-02-01 2007-08-09 Pfizer Products Inc. Spirochromane antagonists of the h-3 receptor
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
MX2010008375A (es) 2008-01-30 2011-03-04 Cephalon Inc Star Derivados de piperidina espirocíclicos substituidos como ligandos de receptores de histamina-3 (h3).

Also Published As

Publication number Publication date
US8513232B2 (en) 2013-08-20
ES2390004T3 (es) 2012-11-05
CA2712897A1 (en) 2009-08-06
WO2009097567A4 (en) 2009-10-29
EP2250176B1 (en) 2012-08-01
JP2011511001A (ja) 2011-04-07
JP5524083B2 (ja) 2014-06-18
WO2009097567A1 (en) 2009-08-06
MX2010008375A (es) 2011-03-04
US20110071131A1 (en) 2011-03-24
EP2250176A1 (en) 2010-11-17

Similar Documents

Publication Publication Date Title
HK1149555A1 (en) Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
EP2120573A4 (en) DERIVATIVES OF PIPERIDINE
AP2989A (en) Substituted piperidines as CCR3 antagonists
IL201112A0 (en) Thiazolidine derivatives as orexin receptor antagonists
IL202665A0 (en) Piperidine derivatives useful as orexin receptor antagonists
IL213345A0 (en) Piperidine derivatives useful as orexin antagonists
HK1149759A1 (en) Substituted spirocyclic cyclohexane derivatives
HK1179958A1 (en) Piperidine derivatives
IL227251A0 (en) Bridged piperidine ant
ZA200906585B (en) Spirocyclic cyclohexane derivatives
ZA201006830B (en) Heterocyclic compounds as adenosine receptor antagonist
IL210613A0 (en) Novel acylaminobenzamide derivatives
ZA201005382B (en) Substituted heteroarylamide diazepinopyrimidone derivatives
HK1155450A1 (en) Tertiary amine derivatives as phosphodiesterase-4 inhibitors -4
ZA201005381B (en) Substituted heteroarylamide oxazepinopyrimidone derivatives
IL213982A0 (en) Piperidine derivatives as nk3 receptor antagonists
IL218525A0 (en) 1,2-dihydro-2-oxoquinoline compounds as 5-ht4 receptor ligands
IL209266A0 (en) Pyrrolidine derivatives as nk2 receptor antagonists
IL202339A0 (en) Azacyclylbenzamide derivatives as histamine-3 antagonists
IL217759A0 (en) Pyrrolidine derivatives as nk3 receptor antagonists
HK1169992A1 (en) Pyrrolidine derivatives as nk - 3 receptor antagonists nk-3
IL207315A0 (en) Piperidine derivative
GB0921210D0 (en) Novel heterocyclic derivatives
ZA200903496B (en) Spiro-piperidine derivatives as via receptor antagonists
EP2283000A4 (en) 3- OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170130