HK1148519A1 - 二酰甘油酰基轉移酶抑制劑 - Google Patents
二酰甘油酰基轉移酶抑制劑Info
- Publication number
- HK1148519A1 HK1148519A1 HK11102583.6A HK11102583A HK1148519A1 HK 1148519 A1 HK1148519 A1 HK 1148519A1 HK 11102583 A HK11102583 A HK 11102583A HK 1148519 A1 HK1148519 A1 HK 1148519A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- diacylglycerol acyltransferase
- acyltransferase inhibitors
- inhibitors
- diacylglycerol
- acyltransferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93136907P | 2007-05-22 | 2007-05-22 | |
US93127307P | 2007-05-22 | 2007-05-22 | |
US93130307P | 2007-05-22 | 2007-05-22 | |
US93132707P | 2007-05-22 | 2007-05-22 | |
PCT/EP2008/055843 WO2008141976A1 (en) | 2007-05-22 | 2008-05-13 | Diacylglycerol acyltransferase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1148519A1 true HK1148519A1 (zh) | 2011-09-09 |
Family
ID=39619031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11102583.6A HK1148519A1 (zh) | 2007-05-22 | 2011-03-15 | 二酰甘油酰基轉移酶抑制劑 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2155687A1 (zh) |
CN (1) | CN101835757B (zh) |
AU (1) | AU2008253118B2 (zh) |
BR (1) | BRPI0811947A2 (zh) |
CA (1) | CA2686951C (zh) |
HK (1) | HK1148519A1 (zh) |
MX (1) | MX2009012285A (zh) |
WO (1) | WO2008141976A1 (zh) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7795283B2 (en) | 2004-12-14 | 2010-09-14 | Astrazeneca Ab | Oxadiazole derivative as DGAT inhibitors |
CN101346387A (zh) | 2005-12-22 | 2009-01-14 | 阿斯利康(瑞典)有限公司 | 用作DGAT抑制剂的嘧啶并-[4,5-b]-噁嗪 |
PL2004607T3 (pl) | 2006-03-31 | 2012-03-30 | Novartis Ag | Pochodne kwasu (4-(4-[6-(trifluorometylopirydyn-3-yloamino)-N-zawierające-heteroarylo]-fenylo)-cykloheksylo)-octowego i ich farmaceutyczne zastosowania |
CN101472905B (zh) | 2006-05-30 | 2011-12-14 | 阿斯利康(瑞典)有限公司 | 作为酰基辅酶甘油二酯酰基转移酶的抑制剂的取代的5-苯基氨基-1,3,4-噁二唑-2-基羰基氨基-4-苯氧基-环己烷甲酸 |
US8153644B2 (en) | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8058299B2 (en) | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8115011B2 (en) | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
JO2972B1 (en) * | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
AU2008258560C1 (en) | 2007-06-08 | 2014-04-10 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
EP2152270B1 (en) | 2007-06-08 | 2015-03-04 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
ES2617619T3 (es) * | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
US8211884B2 (en) | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8324385B2 (en) | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8716312B2 (en) | 2008-11-19 | 2014-05-06 | Merck Sharp & Dohme Corporation | Inhibitors of diacylglycerol acyltransferase |
CN102239165A (zh) * | 2008-12-03 | 2011-11-09 | 维尔制药公司 | 二酰甘油酰基转移酶抑制剂 |
JP2012512252A (ja) * | 2008-12-17 | 2012-05-31 | ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド | ジアシルグリセロールアシルトランスフェラーゼの阻害剤 |
EP2404902A1 (en) | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
WO2011078102A1 (ja) * | 2009-12-22 | 2011-06-30 | 第一三共株式会社 | 新規フェノキシピリミジン誘導体 |
JP5925688B2 (ja) * | 2010-10-14 | 2016-05-25 | 田辺三菱製薬株式会社 | アミド誘導体およびその用途 |
TW201236685A (en) * | 2010-11-11 | 2012-09-16 | Daiichi Sankyo Co Ltd | New pyrazole amide derivatives |
US9453003B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
US9452995B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
US9458151B2 (en) * | 2011-08-11 | 2016-10-04 | Jikai Biosciences, Inc. | Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
CN102924446B (zh) | 2011-08-11 | 2015-08-26 | 上海吉铠医药科技有限公司 | Pim激酶抑制剂及其制备方法与在制药中的应用 |
ES2618955T3 (es) | 2012-04-13 | 2017-06-22 | Mitsubishi Tanabe Pharma Corporation | Derivado de amidopiridina y uso del mismo |
CN104672166A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一种含脒结构的腈基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104710382A (zh) * | 2015-02-10 | 2015-06-17 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的卤代苯基噻唑羧酸酰胺类化合物及用途 |
CN104557765A (zh) * | 2015-02-10 | 2015-04-29 | 佛山市赛维斯医药科技有限公司 | 一类含脒结构的卤代苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104672165B (zh) * | 2015-02-10 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104672164A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一类含苯基脒结构的sglt2/sglt1双靶点抑制剂、其制备方法及用途 |
CN104610187B (zh) * | 2015-02-10 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类含脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104592151A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构sglt2/sglt1双靶点抑制剂及用途 |
CN104592149A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104610189A (zh) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途 |
HUE050986T2 (hu) | 2016-03-17 | 2021-01-28 | Hoffmann La Roche | 5-etil-4-metil-pirazol-3-karboxamid származék, amely TAAR-agonista aktivitású |
KR20200067850A (ko) | 2017-10-06 | 2020-06-12 | 포르마 세라퓨틱스 인크. | 유비퀴틴 특이적 펩티다제 30의 억제 |
RS64321B1 (sr) | 2018-10-05 | 2023-08-31 | Forma Therapeutics Inc | Fuzionisani pirolini koji se ponašaju kao inhibitori ubikvitin specifične proteaze 30 (usp30) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1425014B1 (de) * | 2001-08-31 | 2006-12-13 | Sanofi-Aventis Deutschland GmbH | Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren |
US7553867B2 (en) * | 2002-09-06 | 2009-06-30 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
JP2008543747A (ja) * | 2005-06-11 | 2008-12-04 | アストラゼネカ アクチボラグ | Dgat阻害剤としてのオキサジアゾール誘導体 |
JP5076091B2 (ja) * | 2005-11-28 | 2012-11-21 | マドリガル・ファーマシューティカルズ・インコーポレーテッド | ジアシルグリセロールアシルトランスフェラーゼ(dgat)のインヒビター |
-
2008
- 2008-05-13 BR BRPI0811947-3A2A patent/BRPI0811947A2/pt not_active IP Right Cessation
- 2008-05-13 CN CN200880025656.1A patent/CN101835757B/zh not_active Expired - Fee Related
- 2008-05-13 AU AU2008253118A patent/AU2008253118B2/en not_active Ceased
- 2008-05-13 MX MX2009012285A patent/MX2009012285A/es active IP Right Grant
- 2008-05-13 EP EP08759547A patent/EP2155687A1/en not_active Withdrawn
- 2008-05-13 CA CA2686951A patent/CA2686951C/en not_active Expired - Fee Related
- 2008-05-13 WO PCT/EP2008/055843 patent/WO2008141976A1/en active Application Filing
-
2011
- 2011-03-15 HK HK11102583.6A patent/HK1148519A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN101835757A (zh) | 2010-09-15 |
MX2009012285A (es) | 2009-12-15 |
EP2155687A1 (en) | 2010-02-24 |
AU2008253118A1 (en) | 2008-11-27 |
CA2686951C (en) | 2016-03-22 |
BRPI0811947A2 (pt) | 2014-11-11 |
CN101835757B (zh) | 2014-03-05 |
CA2686951A1 (en) | 2008-11-27 |
WO2008141976A1 (en) | 2008-11-27 |
AU2008253118B2 (en) | 2013-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180513 |