HK1139129A1 - 18f-labelled folates 18f- - Google Patents

18f-labelled folates 18f-

Info

Publication number
HK1139129A1
HK1139129A1 HK10104718.1A HK10104718A HK1139129A1 HK 1139129 A1 HK1139129 A1 HK 1139129A1 HK 10104718 A HK10104718 A HK 10104718A HK 1139129 A1 HK1139129 A1 HK 1139129A1
Authority
HK
Hong Kong
Prior art keywords
folates
labelled
labelled folates
Prior art date
Application number
HK10104718.1A
Other languages
English (en)
Chinese (zh)
Inventor
‧艾梅塔美
‧莫澤
‧羅斯
‧曼德
‧格羅恩
Original Assignee
默克和西伊公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 默克和西伊公司 filed Critical 默克和西伊公司
Publication of HK1139129A1 publication Critical patent/HK1139129A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10104718.1A 2007-04-11 2010-05-14 18f-labelled folates 18f- HK1139129A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105984 2007-04-11
PCT/EP2008/054406 WO2008125615A1 (en) 2007-04-11 2008-04-11 18 f-labelled folates

Publications (1)

Publication Number Publication Date
HK1139129A1 true HK1139129A1 (en) 2010-09-10

Family

ID=39592810

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10104718.1A HK1139129A1 (en) 2007-04-11 2010-05-14 18f-labelled folates 18f-

Country Status (16)

Country Link
US (1) US8344140B2 (xx)
EP (1) EP2144912B1 (xx)
JP (1) JP5595903B2 (xx)
KR (1) KR101639268B1 (xx)
CN (2) CN101657454B (xx)
AU (1) AU2008237932C1 (xx)
CA (1) CA2670371C (xx)
DK (1) DK2144912T3 (xx)
EA (1) EA200901345A1 (xx)
ES (1) ES2397229T3 (xx)
HK (1) HK1139129A1 (xx)
IL (1) IL201251A (xx)
PL (1) PL2144912T3 (xx)
PT (1) PT2144912E (xx)
WO (1) WO2008125615A1 (xx)
ZA (1) ZA200903485B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646639A (zh) * 2007-04-11 2010-02-10 默克阿泼洛发股份公司 18f-标记的叶酸
EA200901345A1 (ru) 2007-04-11 2010-04-30 Мерк Эпрова Аг F-меченые фолаты
TR201901010T4 (tr) 2007-04-11 2019-02-21 Merck & Cie 18F etiketli folatlar.
US20110286921A1 (en) 2008-10-10 2011-11-24 Merck & Cie 18f-labelled folates as pet radiotracers
JP5837486B2 (ja) * 2009-07-03 2015-12-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル カチオン非依存性マンノース６−リン酸受容体を標的とする化合物
WO2012116196A2 (en) * 2011-02-24 2012-08-30 Board Of Regents, The University Of Texas System Substituted lactosyl compounds and use thereof for cellular imaging and therapy
CN103732595B (zh) * 2011-08-17 2017-02-08 默克及其合伙人公司 叶酸的白蛋白‑结合实体缀合物
JP6161209B2 (ja) * 2011-08-22 2017-07-12 メルク・アンド・コンパニー １８ｆ−糖−ホラート
TR201819802T4 (tr) 2012-05-08 2019-01-21 Merck & Cie 18F etiketli folat/antifolat analogları.
CN104844806B (zh) * 2015-05-11 2017-10-17 厦门大学 一种用于核素标记的靶向化合物及其制备方法和应用
CN104830316B (zh) * 2015-05-11 2017-02-01 厦门大学 一种用于核素标记的靶向探针及其制备方法和应用
CN105963724B (zh) * 2016-05-11 2019-01-15 厦门大学 一种放射性标记的肿瘤显像剂、其制备方法和应用
US20210299285A1 (en) * 2018-07-17 2021-09-30 Wake Forest University Health Sciences Compounds useful for in vivo imaging of protein oxidation and/or cancer treatment
KR102137001B1 (ko) * 2018-09-21 2020-07-24 주식회사 비아이케이테라퓨틱스 선택적 아자이드 치환반응과 전구체 제거화를 이용한 플루오린-18이 표지 된 플루오르메틸 치환 방사성의약품의 제조방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458978A (en) 1973-12-11 1976-12-22 Radiochemical Centre Ltd Saturation analysis
US4202976A (en) 1973-09-11 1980-05-13 Bayly Russell J Selenium-75 labelled derivatives of folates
GB1501119A (en) 1974-12-20 1978-02-15 Radiochemical Centre Ltd Folate compounds
US4276280A (en) 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4298735A (en) 1979-04-30 1981-11-03 Union Carbide Corporation Folic acid derivatives
US4337339A (en) 1979-04-30 1982-06-29 Baker Instruments Corp. Process for preparation of folic acid derivatives
US4314988A (en) 1979-10-31 1982-02-09 Baker Instruments Corp. Folic acid derivatives and process for preparation
JPS6144890A (ja) 1984-08-08 1986-03-04 Shionogi & Co Ltd 含フツ素メトトレキサ−ト誘導体
US4628090A (en) 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US4584375A (en) 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US5286726A (en) 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US5066828A (en) 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
EP0761668B1 (en) * 1995-09-08 2002-01-30 The Trustees Of Princeton University Non-classical antifolates
ATE427948T1 (de) * 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
WO2006071754A2 (en) 2004-12-23 2006-07-06 Purdue Research Foundation Positron emission tomography imaging method
US20060263293A1 (en) * 2005-04-27 2006-11-23 Hartmuth Kolb Click chemistry method for synthesizing molecular imaging probes
EP2109466B1 (en) 2007-02-07 2014-11-12 Purdue Research Foundation Positron emission tomography imaging method
EA200901345A1 (ru) 2007-04-11 2010-04-30 Мерк Эпрова Аг F-меченые фолаты

Also Published As

Publication number Publication date
EA200901345A1 (ru) 2010-04-30
ES2397229T3 (es) 2013-03-05
ZA200903485B (en) 2010-04-28
CN101657454A (zh) 2010-02-24
IL201251A (en) 2014-08-31
IL201251A0 (en) 2010-05-31
AU2008237932C1 (en) 2014-04-24
JP2010523625A (ja) 2010-07-15
CN102827166A (zh) 2012-12-19
CN101657454B (zh) 2013-04-24
US8344140B2 (en) 2013-01-01
JP5595903B2 (ja) 2014-09-24
EP2144912A1 (en) 2010-01-20
AU2008237932A1 (en) 2008-10-23
WO2008125615A1 (en) 2008-10-23
KR20090128543A (ko) 2009-12-15
AU2008237932B2 (en) 2014-01-09
PL2144912T3 (pl) 2013-03-29
PT2144912E (pt) 2013-02-01
CA2670371A1 (en) 2008-10-23
KR101639268B1 (ko) 2016-07-13
CA2670371C (en) 2015-01-20
DK2144912T3 (da) 2013-01-14
US20100111863A1 (en) 2010-05-06
EP2144912B1 (en) 2012-11-07

Similar Documents

Publication Publication Date Title
IL244498A0 (en) Micromirror
HK1139129A1 (en) 18f-labelled folates 18f-
AP2010005314A0 (en) Nanodispersian
IL201248A0 (en) 18f - labelled folates
HK1207857A1 (en) 18f-labelled folates 18f-
GB201009543D0 (en) Geothermiesystem
GB2449333B (en) Appetite-control aid
GB2449050B (en) Shoping aid
GB0806623D0 (en) My leener
TWM330776U (en) Ecodesk
AU3642P (en) TAS100 Dianella tasmanica
GB0701006D0 (en) Blankie bear
GB0701388D0 (en) Chair-moving aid
GB0715067D0 (en) Teching aid
GB0707591D0 (en) Westie
IL183430A0 (en) Ecola
AU2007250V (en) Calgreen1GL Calothamnus quadrifidus
AU2007247V (en) CalredGL Calothamnus quadrifidus
AU2007020V (en) Burgundyblush Tristaniopsis laurina
GB0707225D0 (en) Snifsafe
AP2007004122A0 (en) Flashmecash
GB0706680D0 (en) Pan-fan
GB0705047D0 (en) ECO-Lease
GB0703346D0 (en) Energon
GB0707871D0 (en) Magnoheat