HK1139129A1 - -標記的葉酸類 - Google Patents

-標記的葉酸類

Info

Publication number
HK1139129A1
HK1139129A1 HK10104718.1A HK10104718A HK1139129A1 HK 1139129 A1 HK1139129 A1 HK 1139129A1 HK 10104718 A HK10104718 A HK 10104718A HK 1139129 A1 HK1139129 A1 HK 1139129A1
Authority
HK
Hong Kong
Prior art keywords
folates
labelled
labelled folates
Prior art date
Application number
HK10104718.1A
Other languages
English (en)
Inventor
‧艾梅塔美
‧莫澤
‧羅斯
‧曼德
‧格羅恩
Original Assignee
默克和西伊公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 默克和西伊公司 filed Critical 默克和西伊公司
Publication of HK1139129A1 publication Critical patent/HK1139129A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10104718.1A 2007-04-11 2010-05-14 -標記的葉酸類 HK1139129A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105984 2007-04-11
PCT/EP2008/054406 WO2008125615A1 (en) 2007-04-11 2008-04-11 18 f-labelled folates

Publications (1)

Publication Number Publication Date
HK1139129A1 true HK1139129A1 (zh) 2010-09-10

Family

ID=39592810

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10104718.1A HK1139129A1 (zh) 2007-04-11 2010-05-14 -標記的葉酸類

Country Status (16)

Country Link
US (1) US8344140B2 (zh)
EP (1) EP2144912B1 (zh)
JP (1) JP5595903B2 (zh)
KR (1) KR101639268B1 (zh)
CN (2) CN102827166A (zh)
AU (1) AU2008237932C1 (zh)
CA (1) CA2670371C (zh)
DK (1) DK2144912T3 (zh)
EA (1) EA200901345A1 (zh)
ES (1) ES2397229T3 (zh)
HK (1) HK1139129A1 (zh)
IL (1) IL201251A (zh)
PL (1) PL2144912T3 (zh)
PT (1) PT2144912E (zh)
WO (1) WO2008125615A1 (zh)
ZA (1) ZA200903485B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827166A (zh) 2007-04-11 2012-12-19 默克和西伊公司 18f-标记的叶酸类
KR20160074683A (ko) * 2007-04-11 2016-06-28 메르크 앤드 씨에 18ｆ-표지된 폴레이트
ES2707574T3 (es) 2007-04-11 2019-04-04 Merck & Cie Folatos marcados con 18F
PL2346870T3 (pl) 2008-10-10 2016-01-29 Merck & Cie Foliany znakowane fluorem-18 jako radioznaczniki pet
JP5837486B2 (ja) * 2009-07-03 2015-12-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル カチオン非依存性マンノース６−リン酸受容体を標的とする化合物
WO2012116196A2 (en) * 2011-02-24 2012-08-30 Board Of Regents, The University Of Texas System Substituted lactosyl compounds and use thereof for cellular imaging and therapy
EA201400237A1 (ru) * 2011-08-17 2014-08-29 Мерк Э Сие Фолатные конъюгаты альбуминсвязывающих частиц
KR101994327B1 (ko) * 2011-08-22 2019-06-28 메르크 앤드 씨에 18f-당류-폴레이트들
CA2870124C (en) 2012-05-08 2021-02-16 Merck & Cie 18f-labelled folate/antifolate analogues
CN104844806B (zh) * 2015-05-11 2017-10-17 厦门大学 一种用于核素标记的靶向化合物及其制备方法和应用
CN104830316B (zh) * 2015-05-11 2017-02-01 厦门大学 一种用于核素标记的靶向探针及其制备方法和应用
CN105963724B (zh) * 2016-05-11 2019-01-15 厦门大学 一种放射性标记的肿瘤显像剂、其制备方法和应用
WO2020018613A1 (en) * 2018-07-17 2020-01-23 Wake Forest University Health Sciences Compounds useful for in vivo imaging of protein oxidation and/or cancer treatment
KR102137001B1 (ko) * 2018-09-21 2020-07-24 주식회사 비아이케이테라퓨틱스 선택적 아자이드 치환반응과 전구체 제거화를 이용한 플루오린-18이 표지 된 플루오르메틸 치환 방사성의약품의 제조방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458978A (en) 1973-12-11 1976-12-22 Radiochemical Centre Ltd Saturation analysis
US4202976A (en) 1973-09-11 1980-05-13 Bayly Russell J Selenium-75 labelled derivatives of folates
GB1501119A (en) 1974-12-20 1978-02-15 Radiochemical Centre Ltd Folate compounds
US4276280A (en) 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4337339A (en) 1979-04-30 1982-06-29 Baker Instruments Corp. Process for preparation of folic acid derivatives
US4298735A (en) 1979-04-30 1981-11-03 Union Carbide Corporation Folic acid derivatives
US4314988A (en) 1979-10-31 1982-02-09 Baker Instruments Corp. Folic acid derivatives and process for preparation
JPS6144890A (ja) 1984-08-08 1986-03-04 Shionogi & Co Ltd 含フツ素メトトレキサ−ト誘導体
US4584375A (en) 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US4628090A (en) 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US5066828A (en) 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US5286726A (en) 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
CA2184783A1 (en) * 1995-09-08 1997-03-09 William J. Gill Nonclassical antifolates
ATE427948T1 (de) * 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
WO2006071754A2 (en) * 2004-12-23 2006-07-06 Purdue Research Foundation Positron emission tomography imaging method
JP2008540338A (ja) 2005-04-27 2008-11-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 分子画像化プローブのクリックケミストリー合成法
EP2567711A3 (en) 2007-02-07 2013-05-01 Purdue Research Foundation Positron emission tomography imaging method
CN102827166A (zh) 2007-04-11 2012-12-19 默克和西伊公司 18f-标记的叶酸类

Also Published As

Publication number Publication date
JP5595903B2 (ja) 2014-09-24
AU2008237932C1 (en) 2014-04-24
PT2144912E (pt) 2013-02-01
US20100111863A1 (en) 2010-05-06
CA2670371C (en) 2015-01-20
CA2670371A1 (en) 2008-10-23
PL2144912T3 (pl) 2013-03-29
AU2008237932A1 (en) 2008-10-23
EA200901345A1 (ru) 2010-04-30
EP2144912B1 (en) 2012-11-07
ES2397229T3 (es) 2013-03-05
IL201251A0 (en) 2010-05-31
ZA200903485B (en) 2010-04-28
CN101657454A (zh) 2010-02-24
WO2008125615A1 (en) 2008-10-23
JP2010523625A (ja) 2010-07-15
CN101657454B (zh) 2013-04-24
CN102827166A (zh) 2012-12-19
KR101639268B1 (ko) 2016-07-13
KR20090128543A (ko) 2009-12-15
US8344140B2 (en) 2013-01-01
EP2144912A1 (en) 2010-01-20
IL201251A (en) 2014-08-31
DK2144912T3 (da) 2013-01-14
AU2008237932B2 (en) 2014-01-09

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