HK1138581A1 - Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands - Google Patents

Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Info

Publication number
HK1138581A1
HK1138581A1 HK10104249.9A HK10104249A HK1138581A1 HK 1138581 A1 HK1138581 A1 HK 1138581A1 HK 10104249 A HK10104249 A HK 10104249A HK 1138581 A1 HK1138581 A1 HK 1138581A1
Authority
HK
Hong Kong
Prior art keywords
quinolines
triazolo
adenosine
receptor ligands
ligands
Prior art date
Application number
HK10104249.9A
Other languages
English (en)
Inventor
Edit Susan
Kinga Boer
Zoltan Kapui
Geza Timari
Sandor Batori
Zoltan Szlavik
Endre Mikus
Szeredi Judit Vargane
Michel Finet
Szabo Katalin Urban
Tibor Szabo
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HK1138581A1 publication Critical patent/HK1138581A1/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
HK10104249.9A 2007-06-07 2010-04-29 Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands HK1138581A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700395A HUP0700395A2 (en) 2007-06-07 2007-06-07 Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
PCT/HU2008/000063 WO2008149168A1 (en) 2007-06-07 2008-06-02 Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Publications (1)

Publication Number Publication Date
HK1138581A1 true HK1138581A1 (en) 2010-08-27

Family

ID=89987565

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10104249.9A HK1138581A1 (en) 2007-06-07 2010-04-29 Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Country Status (45)

Country Link
US (1) US8338411B2 (pl)
EP (1) EP2167470B1 (pl)
JP (1) JP5487100B2 (pl)
KR (1) KR20100031610A (pl)
CN (1) CN101679272B (pl)
AR (1) AR066873A1 (pl)
AT (1) ATE502016T1 (pl)
AU (1) AU2008259534B2 (pl)
BR (1) BRPI0812257A2 (pl)
CA (1) CA2689612A1 (pl)
CL (1) CL2008001648A1 (pl)
CO (1) CO6270233A2 (pl)
CR (1) CR11171A (pl)
CY (1) CY1111644T1 (pl)
DE (1) DE602008005589D1 (pl)
DK (1) DK2167470T3 (pl)
DO (1) DOP2009000276A (pl)
EC (1) ECSP099783A (pl)
ES (1) ES2363672T3 (pl)
GT (1) GT200900301A (pl)
HK (1) HK1138581A1 (pl)
HN (1) HN2009003357A (pl)
HR (1) HRP20110332T1 (pl)
HU (1) HUP0700395A2 (pl)
IL (1) IL202471A0 (pl)
JO (1) JO2689B1 (pl)
MA (1) MA31738B1 (pl)
ME (1) ME00958B (pl)
MX (1) MX2009013209A (pl)
MY (1) MY148654A (pl)
NI (1) NI200900210A (pl)
NZ (1) NZ581186A (pl)
PA (1) PA8782901A1 (pl)
PE (1) PE20090325A1 (pl)
PL (1) PL2167470T3 (pl)
PT (1) PT2167470E (pl)
RU (1) RU2489432C2 (pl)
SI (1) SI2167470T1 (pl)
SV (1) SV2009003420A (pl)
TN (1) TN2009000482A1 (pl)
TW (1) TWI424998B (pl)
UA (1) UA99463C2 (pl)
UY (1) UY31130A1 (pl)
WO (1) WO2008149168A1 (pl)
ZA (1) ZA200908280B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8884034B2 (en) 2009-07-08 2014-11-11 Dermira (Canada), Inc. TOFA analogs useful in treating dermatological disorders or conditions
FR3053968A1 (fr) * 2016-07-13 2018-01-19 Biomerieux Reactifs pour la protection reversible de molecules biologiques
MY195054A (en) * 2016-09-24 2023-01-05 Kbp Biosciences Co Ltd Pharmaceutical Composition Comprising Mineralocorticoid Receptor Antagonist and use Thereof
CN112384515A (zh) 2018-02-27 2021-02-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
JP7391046B2 (ja) 2018-05-18 2023-12-04 インサイト・コーポレイション A2a/a2b阻害剤としての縮合ピリミジン誘導体
EP3818063A1 (en) 2018-07-05 2021-05-12 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
EA202191498A1 (ru) 2018-11-30 2021-08-20 Мерк Шарп энд Доум Корп. 9-замещенные производные аминотриазолохиназолина в качестве антагонистов аденозиновых рецепторов, фармацевтические композиции и их применение
MX2021007426A (es) 2018-12-20 2021-09-08 Incyte Corp Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina.
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479759A (en) * 1974-11-23 1977-07-13 Lepetit Spa Heterocyclic fused derivatives of indole and quinoline
GR76063B (pl) * 1981-04-03 1984-08-03 Roussel Uclaf
ZA836701B (en) * 1982-10-01 1984-10-31 Roussel Uclaf Imidazo(1,2-a)quinolines
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
IL158854A0 (en) * 2001-05-31 2004-05-12 Sanofi Synthelabo Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
US6514989B1 (en) 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0105406A3 (en) * 2001-12-21 2003-12-29 Sanofi Aventis Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
ES2254778T3 (es) 2001-12-21 2006-06-16 Jsw-Research Forschungslabor Gmbh Triazoloquinoxalinas sustituidas con pirazolilo.
HUP0203976A3 (en) * 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
MEP19108A (en) * 2003-07-31 2010-06-10 Sanofi Aventis Aminoquinoline derivatives and their use as adenosine a3 ligands

Also Published As

Publication number Publication date
HU0700395D0 (en) 2007-07-30
UA99463C2 (en) 2012-08-27
JP2010529100A (ja) 2010-08-26
DOP2009000276A (es) 2010-01-31
GT200900301A (es) 2010-04-22
CO6270233A2 (es) 2011-04-20
IL202471A0 (en) 2010-06-30
ME00958B (me) 2012-06-20
US8338411B2 (en) 2012-12-25
US20100216786A1 (en) 2010-08-26
HN2009003357A (es) 2013-08-12
DK2167470T3 (da) 2011-06-27
ECSP099783A (es) 2010-01-29
MY148654A (en) 2013-05-15
ES2363672T3 (es) 2011-08-11
WO2008149168A8 (en) 2010-01-07
WO2008149168A1 (en) 2008-12-11
MX2009013209A (es) 2010-04-09
PT2167470E (pt) 2011-05-16
PE20090325A1 (es) 2009-04-17
KR20100031610A (ko) 2010-03-23
AU2008259534A1 (en) 2008-12-11
HRP20110332T1 (hr) 2011-06-30
JP5487100B2 (ja) 2014-05-07
CR11171A (es) 2010-04-21
JO2689B1 (en) 2013-03-03
TW200914451A (en) 2009-04-01
CN101679272B (zh) 2013-02-06
AR066873A1 (es) 2009-09-16
PL2167470T3 (pl) 2011-08-31
PA8782901A1 (es) 2009-01-23
CL2008001648A1 (es) 2008-10-10
DE602008005589D1 (de) 2011-04-28
RU2009149518A (ru) 2011-07-20
AU2008259534B2 (en) 2012-07-05
EP2167470B1 (en) 2011-03-16
SV2009003420A (es) 2010-04-26
TWI424998B (zh) 2014-02-01
SI2167470T1 (sl) 2011-06-30
CN101679272A (zh) 2010-03-24
NZ581186A (en) 2012-03-30
UY31130A1 (es) 2009-01-30
ZA200908280B (en) 2010-07-28
ATE502016T1 (de) 2011-04-15
HUP0700395A2 (en) 2009-03-02
NI200900210A (es) 2010-07-15
TN2009000482A1 (en) 2011-03-31
CA2689612A1 (en) 2008-12-11
RU2489432C2 (ru) 2013-08-10
MA31738B1 (fr) 2010-10-01
EP2167470A1 (en) 2010-03-31
CY1111644T1 (el) 2015-10-07
BRPI0812257A2 (pt) 2014-12-23

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150602