PL2167470T3 - Triazolo[1,5A]chinoliny jako ligandy receptora adenozynowego A3 - Google Patents

Triazolo[1,5A]chinoliny jako ligandy receptora adenozynowego A3

Info

Publication number
PL2167470T3
PL2167470T3 PL08762666T PL08762666T PL2167470T3 PL 2167470 T3 PL2167470 T3 PL 2167470T3 PL 08762666 T PL08762666 T PL 08762666T PL 08762666 T PL08762666 T PL 08762666T PL 2167470 T3 PL2167470 T3 PL 2167470T3
Authority
PL
Poland
Prior art keywords
quinolines
triazolo
adenosine
receptor ligands
ligands
Prior art date
Application number
PL08762666T
Other languages
English (en)
Inventor
Edit Susán
Kinga Boér
Zoltán Kapui
Géza Timári
Sándor Bátori
Zoltán Szlávik
Endre Mikus
Szeredi Judit Vargáné
Michel Finet
Szabó Katalin Urbán
Tibor Szabó
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PL2167470T3 publication Critical patent/PL2167470T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
PL08762666T 2007-06-07 2008-06-02 Triazolo[1,5A]chinoliny jako ligandy receptora adenozynowego A3 PL2167470T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0700395A HUP0700395A2 (en) 2007-06-07 2007-06-07 Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
EP08762666A EP2167470B1 (en) 2007-06-07 2008-06-02 Triazolo [1, 5-a]quinolines as adenosine a3 receptor ligands
PCT/HU2008/000063 WO2008149168A1 (en) 2007-06-07 2008-06-02 Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Publications (1)

Publication Number Publication Date
PL2167470T3 true PL2167470T3 (pl) 2011-08-31

Family

ID=89987565

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08762666T PL2167470T3 (pl) 2007-06-07 2008-06-02 Triazolo[1,5A]chinoliny jako ligandy receptora adenozynowego A3

Country Status (45)

Country Link
US (1) US8338411B2 (pl)
EP (1) EP2167470B1 (pl)
JP (1) JP5487100B2 (pl)
KR (1) KR20100031610A (pl)
CN (1) CN101679272B (pl)
AR (1) AR066873A1 (pl)
AT (1) ATE502016T1 (pl)
AU (1) AU2008259534B2 (pl)
BR (1) BRPI0812257A2 (pl)
CA (1) CA2689612A1 (pl)
CL (1) CL2008001648A1 (pl)
CO (1) CO6270233A2 (pl)
CR (1) CR11171A (pl)
CY (1) CY1111644T1 (pl)
DE (1) DE602008005589D1 (pl)
DK (1) DK2167470T3 (pl)
DO (1) DOP2009000276A (pl)
EC (1) ECSP099783A (pl)
ES (1) ES2363672T3 (pl)
GT (1) GT200900301A (pl)
HK (1) HK1138581A1 (pl)
HN (1) HN2009003357A (pl)
HR (1) HRP20110332T1 (pl)
HU (1) HUP0700395A2 (pl)
IL (1) IL202471A0 (pl)
JO (1) JO2689B1 (pl)
MA (1) MA31738B1 (pl)
ME (1) ME00958B (pl)
MX (1) MX2009013209A (pl)
MY (1) MY148654A (pl)
NI (1) NI200900210A (pl)
NZ (1) NZ581186A (pl)
PA (1) PA8782901A1 (pl)
PE (1) PE20090325A1 (pl)
PL (1) PL2167470T3 (pl)
PT (1) PT2167470E (pl)
RU (1) RU2489432C2 (pl)
SI (1) SI2167470T1 (pl)
SV (1) SV2009003420A (pl)
TN (1) TN2009000482A1 (pl)
TW (1) TWI424998B (pl)
UA (1) UA99463C2 (pl)
UY (1) UY31130A1 (pl)
WO (1) WO2008149168A1 (pl)
ZA (1) ZA200908280B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012000254A2 (pt) 2009-07-08 2016-02-16 Dermira Canada Inc análogos de tofa úteis no tratamento de distúrbios ou condições dermatológicas.
FR3053968A1 (fr) * 2016-07-13 2018-01-19 Biomerieux Reactifs pour la protection reversible de molecules biologiques
CU24569B1 (es) 2016-09-24 2022-01-13 Kbp Biosciences Co Ltd Composición farmacéutica como antagonista del receptor de mineralocorticoides
AU2019227607C1 (en) 2018-02-27 2023-07-20 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
JP7391046B2 (ja) 2018-05-18 2023-12-04 インサイト・コーポレイション Ａ２ａ／ａ２ｂ阻害剤としての縮合ピリミジン誘導体
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479759A (en) * 1974-11-23 1977-07-13 Lepetit Spa Heterocyclic fused derivatives of indole and quinoline
GR76063B (pl) * 1981-04-03 1984-08-03 Roussel Uclaf
ZA836701B (en) * 1982-10-01 1984-10-31 Roussel Uclaf Imidazo(1,2-a)quinolines
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
BR0209719A (pt) * 2001-05-31 2004-07-27 Sanofi Synthelabo Derivados de aminoquinolina e aminopiridina e seu uso como ligandos de adenosina a3
US6514989B1 (en) 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
HUP0105406A3 (en) * 2001-12-21 2003-12-29 Sanofi Aventis Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
JP2005523244A (ja) 2001-12-21 2005-08-04 ジエイエスダブリユー−リサーチ・フオルシユンクスラバー・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング ピラゾリル置換トリアゾロキノキサリン
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0203976A3 (en) * 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
MXPA06001254A (es) * 2003-07-31 2006-05-17 Sanofi Aventis Derivados de aminoquinolina y su uso como ligantes de adenosina a3.

Also Published As

Publication number Publication date
HK1138581A1 (en) 2010-08-27
CN101679272A (zh) 2010-03-24
WO2008149168A8 (en) 2010-01-07
MX2009013209A (es) 2010-04-09
NZ581186A (en) 2012-03-30
UA99463C2 (en) 2012-08-27
EP2167470A1 (en) 2010-03-31
DOP2009000276A (es) 2010-01-31
EP2167470B1 (en) 2011-03-16
ATE502016T1 (de) 2011-04-15
HUP0700395A2 (en) 2009-03-02
TWI424998B (zh) 2014-02-01
BRPI0812257A2 (pt) 2014-12-23
HU0700395D0 (en) 2007-07-30
DE602008005589D1 (de) 2011-04-28
ME00958B (me) 2012-06-20
MY148654A (en) 2013-05-15
ECSP099783A (es) 2010-01-29
CR11171A (es) 2010-04-21
SI2167470T1 (sl) 2011-06-30
MA31738B1 (fr) 2010-10-01
PA8782901A1 (es) 2009-01-23
DK2167470T3 (da) 2011-06-27
PT2167470E (pt) 2011-05-16
AR066873A1 (es) 2009-09-16
JP2010529100A (ja) 2010-08-26
NI200900210A (es) 2010-07-15
GT200900301A (es) 2010-04-22
KR20100031610A (ko) 2010-03-23
WO2008149168A1 (en) 2008-12-11
ZA200908280B (en) 2010-07-28
US8338411B2 (en) 2012-12-25
RU2489432C2 (ru) 2013-08-10
TN2009000482A1 (en) 2011-03-31
PE20090325A1 (es) 2009-04-17
HN2009003357A (es) 2013-08-12
UY31130A1 (es) 2009-01-30
CA2689612A1 (en) 2008-12-11
TW200914451A (en) 2009-04-01
HRP20110332T1 (hr) 2011-06-30
AU2008259534A1 (en) 2008-12-11
US20100216786A1 (en) 2010-08-26
JO2689B1 (en) 2013-03-03
SV2009003420A (es) 2010-04-26
RU2009149518A (ru) 2011-07-20
ES2363672T3 (es) 2011-08-11
CN101679272B (zh) 2013-02-06
CL2008001648A1 (es) 2008-10-10
JP5487100B2 (ja) 2014-05-07
CO6270233A2 (es) 2011-04-20
CY1111644T1 (el) 2015-10-07
IL202471A0 (en) 2010-06-30
AU2008259534B2 (en) 2012-07-05

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