HK1136824B - 丙型肝炎病毒的大环化合物抑制剂 - Google Patents

丙型肝炎病毒的大环化合物抑制剂 Download PDF

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Publication number
HK1136824B
HK1136824B HK10102144.9A HK10102144A HK1136824B HK 1136824 B HK1136824 B HK 1136824B HK 10102144 A HK10102144 A HK 10102144A HK 1136824 B HK1136824 B HK 1136824B
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HK
Hong Kong
Prior art keywords
formula
alkyl
compound
compounds
hydrogen
Prior art date
Application number
HK10102144.9A
Other languages
German (de)
English (en)
French (fr)
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HK1136824A1 (zh
Inventor
Pierre Jean-Marie Bernard Raboisson
Herman Augustinus De Kock
David Craig Mc Gowan
Wim Van De Vreken
Lili Hu
Abdellah Tahri
Sandrine Marie Helene Vendeville
Original Assignee
Janssen R&D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Priority claimed from PCT/EP2007/062436 external-priority patent/WO2008059046A1/en
Publication of HK1136824A1 publication Critical patent/HK1136824A1/zh
Publication of HK1136824B publication Critical patent/HK1136824B/zh

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Abstract

式(I)的HCV复制抑制剂及其盐和立体异构体，其中各虚线(由- - -代表任选的双键；X是N、CH，并且当X带有双键时，它是C；R1为-OR7、-NH-SO2R8；R2是氢，和其中X是C或CH，R2也可以是C1-6烷基；R3为氢、C1-6烷基、C1-6烷氧基C1-6烷基、C3-7环烷基；n是3、4、5或6；R4为C1-6烷基或C3-7环烷基；R5为氢、卤素、C1-6烷基、羟基、C1-6烷氧基、多卤代C1-6烷基；R6为氢、C1-6烷氧基、单-或二C1-6烷基氨基；或者R5和R6可以形成5-或6-元不饱和或部分不饱和的环，任选地包含选自O、N和S中的一种或两种；R7是氢；任选被C1-6烷基取代的C3-7环烷基；或任选被C3-7环烷基取代的C1-6烷基；R8为任选被C1-6烷基取代的C3-7环烷基；任选被C3-7环烷基取代的C1-6烷基；或-NR8 aR8b；R8a和R8b是C1-6烷基，或两者可以形成5-或6-元饱和杂环；含有化合物(I)的药物组合物和制备化合物(I)的方法。
HK10102144.9A 2006-11-17 2007-11-16 丙型肝炎病毒的大环化合物抑制剂 HK1136824B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06124359 2006-11-17
EP06124359 2006-11-17
PCT/EP2007/062436 WO2008059046A1 (en) 2006-11-17 2007-11-16 Macrocyclic inhibitors of hepatitis c virus

Publications (2)

Publication Number Publication Date
HK1136824A1 HK1136824A1 (zh) 2010-07-09
HK1136824B true HK1136824B (zh) 2014-10-31

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