HK1135958A1 - Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate - Google Patents
Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rateInfo
- Publication number
- HK1135958A1 HK1135958A1 HK10100235.3A HK10100235A HK1135958A1 HK 1135958 A1 HK1135958 A1 HK 1135958A1 HK 10100235 A HK10100235 A HK 10100235A HK 1135958 A1 HK1135958 A1 HK 1135958A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ibuprofen
- positively charged
- skin penetration
- penetration rate
- charged water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052461 WO2008010025A1 (en) | 2006-07-18 | 2006-07-18 | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1135958A1 true HK1135958A1 (en) | 2010-06-18 |
Family
ID=38956590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10100235.3A HK1135958A1 (en) | 2006-07-18 | 2010-01-11 | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP3210964A1 (xx) |
JP (1) | JP5144658B2 (xx) |
CN (1) | CN101489985B (xx) |
AU (1) | AU2006346288A1 (xx) |
CA (1) | CA2657636C (xx) |
DK (1) | DK2041068T3 (xx) |
ES (1) | ES2616315T3 (xx) |
HK (1) | HK1135958A1 (xx) |
HU (1) | HUE033687T2 (xx) |
PL (1) | PL2041068T3 (xx) |
PT (1) | PT2041068T (xx) |
WO (1) | WO2008010025A1 (xx) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
EP2084124B9 (en) | 2006-10-02 | 2015-07-01 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
CN101541743A (zh) | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药系统 |
ES2633020T3 (es) | 2006-12-10 | 2017-09-18 | Yu, Chongxi-Techfields Biochem | Sistemas de administración transdérmica de antibióticos betalactámicos |
JP5826459B2 (ja) | 2007-01-15 | 2015-12-02 | チョンシー ユー | 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ |
AU2007345952C1 (en) | 2007-01-31 | 2017-06-08 | Chongxi Yu | Positively charged water-soluble prodrugs of 1H-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
KR20180049144A (ko) | 2007-06-04 | 2018-05-10 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
JP2012511027A (ja) * | 2008-12-04 | 2012-05-17 | チョンシー ユー | 高透過性組成物およびその用途 |
CN102427809B (zh) * | 2009-03-16 | 2014-10-01 | 根梅迪卡治疗公司 | 用于治疗代谢性疾病的抗炎剂和抗氧化剂轭合物 |
CN102459313A (zh) | 2009-05-08 | 2012-05-16 | 上海泰飞尔生化技术有限公司 | 多肽和多肽相关化合物的高穿透力前药组合物 |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
CN103607888A (zh) * | 2011-04-08 | 2014-02-26 | 斯法尔制药私人有限公司 | 取代的甲基甲酰基试剂以及使用所述试剂改进化合物的物理化学性质和/或药代动力学性质的方法 |
KR102309973B1 (ko) | 2012-01-18 | 2021-10-06 | 테크필즈 파마 코., 엘티디. | 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물 |
MX2015012559A (es) | 2013-03-15 | 2016-07-18 | Techfields Pharma Co Ltd | Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson. |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
JP6153264B2 (ja) * | 2015-01-05 | 2017-06-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するnsaiaプロドラッグ及びその新規医薬使用 |
WO2019080693A1 (zh) * | 2017-10-26 | 2019-05-02 | 浙江越甲药业有限公司 | 一种稳定的含有非甾体抗炎药衍生物的药物组合物 |
CA3096700C (en) | 2018-04-26 | 2023-08-22 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
CN112206222A (zh) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | 含有布洛芬结构类似物的多层经皮给药系统 |
US11389409B2 (en) * | 2019-08-30 | 2022-07-19 | Remedy Diagnostics LLC | Transdermal device comprising acetaminophen prodrug |
IL302978A (en) * | 2020-06-05 | 2023-07-01 | Techfields Inc | Local administration of 2-(diethylamino)ethyl 2-(4-isobutylphenyl)propionate for the treatment of diseases |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6898287A (en) | 1986-01-30 | 1987-08-25 | University Of Utah, The | Treatment of bone loss |
IT1208736B (it) * | 1986-03-04 | 1989-07-10 | Sigma Tau Ind Farmaceuti | Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica |
AU1508988A (en) * | 1987-04-27 | 1988-10-27 | Syntex Pharmaceuticals International Ltd. | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
US5100918A (en) | 1989-05-25 | 1992-03-31 | Sterling Drug, Inc. | Prevention or treatment of sunburn using the S(+) isomer of ibuprofen |
AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
DE19716713A1 (de) * | 1997-04-21 | 1998-10-22 | Paz Arzneimittelentwicklung | Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz |
US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
CA2336682C (en) | 1998-07-07 | 2006-10-10 | Transdermal Technologies, Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
US6645520B2 (en) * | 1999-12-16 | 2003-11-11 | Dermatrends, Inc. | Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers |
US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
WO2002085297A2 (en) * | 2001-04-24 | 2002-10-31 | East Carolina University | Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
WO2008007171A1 (en) * | 2006-07-09 | 2008-01-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
PL2046727T3 (pl) * | 2006-07-25 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki diklofenaku o bardzo szybkim stopniu przenikania przez skórę |
AU2006347391B2 (en) * | 2006-08-15 | 2013-03-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
-
2006
- 2006-07-18 EP EP17152505.8A patent/EP3210964A1/en not_active Withdrawn
- 2006-07-18 CA CA2657636A patent/CA2657636C/en active Active
- 2006-07-18 HU HUE06780126A patent/HUE033687T2/en unknown
- 2006-07-18 ES ES06780126.6T patent/ES2616315T3/es active Active
- 2006-07-18 DK DK06780126.6T patent/DK2041068T3/en active
- 2006-07-18 CN CN200680055379.XA patent/CN101489985B/zh active Active
- 2006-07-18 EP EP06780126.6A patent/EP2041068B1/en not_active Not-in-force
- 2006-07-18 WO PCT/IB2006/052461 patent/WO2008010025A1/en active Application Filing
- 2006-07-18 AU AU2006346288A patent/AU2006346288A1/en not_active Abandoned
- 2006-07-18 PL PL06780126T patent/PL2041068T3/pl unknown
- 2006-07-18 PT PT67801266T patent/PT2041068T/pt unknown
- 2006-07-18 JP JP2009520065A patent/JP5144658B2/ja not_active Expired - Fee Related
-
2010
- 2010-01-11 HK HK10100235.3A patent/HK1135958A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL2041068T3 (pl) | 2017-05-31 |
CA2657636C (en) | 2021-11-09 |
EP2041068B1 (en) | 2017-01-25 |
ES2616315T3 (es) | 2017-06-12 |
EP2041068A1 (en) | 2009-04-01 |
DK2041068T3 (en) | 2017-02-27 |
AU2006346288A1 (en) | 2008-01-24 |
WO2008010025A1 (en) | 2008-01-24 |
JP2009543857A (ja) | 2009-12-10 |
HUE033687T2 (en) | 2017-12-28 |
CN101489985A (zh) | 2009-07-22 |
CA2657636A1 (en) | 2008-01-24 |
JP5144658B2 (ja) | 2013-02-13 |
PT2041068T (pt) | 2017-02-17 |
EP3210964A1 (en) | 2017-08-30 |
EP2041068A4 (en) | 2010-09-29 |
CN101489985B (zh) | 2014-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1215805A1 (zh) | 具有快速皮膚穿透速度的帶正電荷的水溶性雙氯芬酸前藥 | |
HK1135958A1 (en) | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate | |
PL2061749T3 (pl) | Dodatnio naładowane, rozpuszczalne w wodzie proleki acetaminofenu i związków pokrewnych o bardzo dużej szybkości przenikania przez skórę | |
HK1202524A1 (en) | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates | |
HK1137425A1 (en) | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate | |
HK1137426A1 (en) | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate | |
HK1136814A1 (en) | Positively charged water-soluble prodrugs of diflunisal and related compounds with very fast skin penetration rate | |
EP2125697A4 (en) | POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF RETINOIDS AND RETINOIDARY COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES | |
HK1220970A1 (zh) | 偶聯物及其使用方法 | |
EP2084165A4 (en) | PRO-DRUGS OF WATER-SOLUBLE OXICAMS POSITIVE AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION SPEED | |
PT2049482E (pt) | Profármacos solúveis em água carregados positivamente de ácidos aril- e heteroarilacéticos com velocidade de penetração na pele muito rápida | |
EP2647644A4 (en) | RNA MODIFIED BY 2'-O | |
HK1160725A1 (en) | Carbonate prodrugs and methods of using the same | |
IL209382A0 (en) | Water-soluble acetaminophen analogs | |
HK1216096A1 (zh) | 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥 | |
GB201118517D0 (en) | Article formed using nanostructured ferritic alloy | |
EP2269612A4 (en) | EYE DROP PREPARATION AND ITS USE | |
EP2322608A4 (en) | TRANSFECTION AGENT | |
HK1208184A1 (en) | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate | |
HK1208214A1 (en) | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate | |
PL2440526T3 (pl) | 3-halogeno-6-(arylo)-4-iminotetrahydropikoliniany i ich zastosowanie jako herbicydów | |
EP2373306A4 (en) | ALISKIRENE WITH TRANSVERSE ADMINISTRATION | |
IL213560A0 (en) | Enema formulations | |
HK1202115A1 (en) | Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate | |
HK1200031A1 (en) | Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate |