HK1135958A1 - Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate - Google Patents
Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rateInfo
- Publication number
- HK1135958A1 HK1135958A1 HK10100235.3A HK10100235A HK1135958A1 HK 1135958 A1 HK1135958 A1 HK 1135958A1 HK 10100235 A HK10100235 A HK 10100235A HK 1135958 A1 HK1135958 A1 HK 1135958A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ibuprofen
- positively charged
- skin penetration
- penetration rate
- charged water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052461 WO2008010025A1 (en) | 2006-07-18 | 2006-07-18 | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1135958A1 true HK1135958A1 (en) | 2010-06-18 |
Family
ID=38956590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10100235.3A HK1135958A1 (en) | 2006-07-18 | 2010-01-11 | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP2041068B1 (xx) |
JP (1) | JP5144658B2 (xx) |
CN (1) | CN101489985B (xx) |
AU (1) | AU2006346288A1 (xx) |
CA (1) | CA2657636C (xx) |
DK (1) | DK2041068T3 (xx) |
ES (1) | ES2616315T3 (xx) |
HK (1) | HK1135958A1 (xx) |
HU (1) | HUE033687T2 (xx) |
PL (1) | PL2041068T3 (xx) |
PT (1) | PT2041068T (xx) |
WO (1) | WO2008010025A1 (xx) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
WO2008041054A1 (en) | 2006-10-02 | 2008-04-10 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
EP2656879B1 (en) | 2006-12-10 | 2017-06-28 | Chongxi Yu | Transdermal delivery systems of beta-lactam antibiotics |
CA2674822C (en) | 2007-01-15 | 2017-08-01 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
ES2607901T3 (es) | 2007-01-31 | 2017-04-04 | Chongxi Yu | Profármacos hidrosolubles cargados positivamente de 1H-imidazo[4,5-c]quinolin-4-aminas y compuestos relacionados con ratas de penetración de piel muy altas |
WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
PL2170826T3 (pl) * | 2007-06-04 | 2022-09-05 | Techfields Inc | Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze |
CA3213470A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
EP2408443A1 (en) * | 2009-03-16 | 2012-01-25 | Genmedica Therapeutics SL | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
DK2427475T3 (da) | 2009-05-08 | 2021-02-01 | Techfields Biochem Co Ltd | Prodrug-sammensætninger med høj gennemtrængelighed af peptider og peptid-relaterede forbindelser |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
CN109608436B (zh) * | 2011-04-08 | 2022-10-11 | 斯法尔制药私人有限公司 | 取代的甲基甲酰基试剂及使用所述试剂改进化合物物理化学和/或药代动力学性质的方法 |
CA3189252A1 (en) | 2012-05-16 | 2013-11-21 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
WO2014139161A1 (en) * | 2013-03-15 | 2014-09-18 | Techfields Pharma Co., Ltd. | Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
JP6153264B2 (ja) * | 2015-01-05 | 2017-06-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するnsaiaプロドラッグ及びその新規医薬使用 |
EP3701937A4 (en) | 2017-10-26 | 2021-07-28 | Zhejiang Yuejia Pharmaceuticals Co., Ltd | STABLE PHARMACEUTICAL COMPOSITION CONTAINING A NON-STEROID ANTI-INFLAMMATORY DERIVATIVE |
JP7169008B2 (ja) | 2018-04-26 | 2022-11-10 | エーディーティー ファーマシューティカルズ,エルエルシー | 抗がんインデン、インダン、アザインデン、アザインダン、医薬組成物および使用 |
CN112206222A (zh) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | 含有布洛芬结构类似物的多层经皮给药系统 |
WO2021041800A1 (en) * | 2019-08-30 | 2021-03-04 | Remedy Diagnostics LLC | Transdermal device comprising pain molecules |
KR20230018481A (ko) * | 2020-06-05 | 2023-02-07 | 테크필즈 인크. | 질병의 치료를 위한 2-(다이에틸아미노)에틸 2-(4-아이소부틸페닐)프로피오네이트의 국소 투여 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6898287A (en) | 1986-01-30 | 1987-08-25 | University Of Utah, The | Treatment of bone loss |
IT1208736B (it) * | 1986-03-04 | 1989-07-10 | Sigma Tau Ind Farmaceuti | Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica |
ZA882957B (en) * | 1987-04-27 | 1989-12-27 | Syntex Pharma Int | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs |
US5100918A (en) | 1989-05-25 | 1992-03-31 | Sterling Drug, Inc. | Prevention or treatment of sunburn using the S(+) isomer of ibuprofen |
AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
DE19716713A1 (de) * | 1997-04-21 | 1998-10-22 | Paz Arzneimittelentwicklung | Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz |
US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
AU4972599A (en) | 1998-07-07 | 2000-01-24 | Transdermal Technologies, Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
US6645520B2 (en) * | 1999-12-16 | 2003-11-11 | Dermatrends, Inc. | Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers |
US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
WO2002085297A2 (en) * | 2001-04-24 | 2002-10-31 | East Carolina University | Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
WO2008007171A1 (en) * | 2006-07-09 | 2008-01-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
CA2658712C (en) * | 2006-07-25 | 2018-10-02 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of diclofenac with very fast skin penetration rate |
EP2054384A4 (en) * | 2006-08-15 | 2010-11-03 | Techfields Biochem Co Ltd | POSITIVELY LOADED WATER-SOLUBLE PRODRUGS OF ARYL AND HETEROARYLPROPIONIC ACIDS WITH A VERY FAST SKIN PUNCHING RATE |
-
2006
- 2006-07-18 WO PCT/IB2006/052461 patent/WO2008010025A1/en active Application Filing
- 2006-07-18 ES ES06780126.6T patent/ES2616315T3/es active Active
- 2006-07-18 PT PT67801266T patent/PT2041068T/pt unknown
- 2006-07-18 JP JP2009520065A patent/JP5144658B2/ja not_active Expired - Fee Related
- 2006-07-18 CA CA2657636A patent/CA2657636C/en active Active
- 2006-07-18 CN CN200680055379.XA patent/CN101489985B/zh active Active
- 2006-07-18 DK DK06780126.6T patent/DK2041068T3/en active
- 2006-07-18 HU HUE06780126A patent/HUE033687T2/en unknown
- 2006-07-18 PL PL06780126T patent/PL2041068T3/pl unknown
- 2006-07-18 AU AU2006346288A patent/AU2006346288A1/en not_active Abandoned
- 2006-07-18 EP EP06780126.6A patent/EP2041068B1/en not_active Not-in-force
- 2006-07-18 EP EP17152505.8A patent/EP3210964A1/en not_active Withdrawn
-
2010
- 2010-01-11 HK HK10100235.3A patent/HK1135958A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008010025A1 (en) | 2008-01-24 |
PT2041068T (pt) | 2017-02-17 |
HUE033687T2 (en) | 2017-12-28 |
EP2041068B1 (en) | 2017-01-25 |
CN101489985A (zh) | 2009-07-22 |
PL2041068T3 (pl) | 2017-05-31 |
CN101489985B (zh) | 2014-01-08 |
JP5144658B2 (ja) | 2013-02-13 |
CA2657636C (en) | 2021-11-09 |
CA2657636A1 (en) | 2008-01-24 |
EP2041068A1 (en) | 2009-04-01 |
AU2006346288A1 (en) | 2008-01-24 |
DK2041068T3 (en) | 2017-02-27 |
JP2009543857A (ja) | 2009-12-10 |
ES2616315T3 (es) | 2017-06-12 |
EP3210964A1 (en) | 2017-08-30 |
EP2041068A4 (en) | 2010-09-29 |
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