HK1135431A1 - Therapeutic applications of activation of human antigen-presenting cells through dectin-1 - Google Patents

Therapeutic applications of activation of human antigen-presenting cells through dectin-1

Info

Publication number
HK1135431A1
HK1135431A1 HK10102278.7A HK10102278A HK1135431A1 HK 1135431 A1 HK1135431 A1 HK 1135431A1 HK 10102278 A HK10102278 A HK 10102278A HK 1135431 A1 HK1135431 A1 HK 1135431A1
Authority
HK
Hong Kong
Prior art keywords
dectin
activation
presenting cells
therapeutic applications
human antigen
Prior art date
Application number
HK10102278.7A
Other languages
English (en)
Inventor
Jacques F Banchereau
Sangkon Oh
Gerard Zurawski
Sandra Zurawski
Ling Ni
Original Assignee
Baylor Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Inst filed Critical Baylor Res Inst
Publication of HK1135431A1 publication Critical patent/HK1135431A1/xx

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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HK10102278.7A 2007-02-23 2010-03-03 Therapeutic applications of activation of human antigen-presenting cells through dectin-1 HK1135431A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89142507P 2007-02-23 2007-02-23
PCT/US2008/054798 WO2008118587A2 (en) 2007-02-23 2008-02-22 Therapeutic applications of activation of human antigen-presenting cells through dectin-1

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HK1135431A1 true HK1135431A1 (en) 2010-06-04

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US (2) US20080233140A1 (es)
EP (2) EP2129773B1 (es)
JP (5) JP2010519316A (es)
KR (1) KR20090114466A (es)
CN (1) CN101679949B (es)
AU (1) AU2008231242B2 (es)
BR (1) BRPI0807617A2 (es)
CA (1) CA2717659C (es)
HK (1) HK1135431A1 (es)
IL (2) IL200527A0 (es)
MX (1) MX2009008926A (es)
NZ (7) NZ600143A (es)
TW (1) TWI423985B (es)
WO (1) WO2008118587A2 (es)
ZA (1) ZA200906619B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI422594B (zh) 2007-02-02 2014-01-11 Baylor Res Inst 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑
AU2010286518C1 (en) 2009-08-29 2015-08-27 Abbvie Inc. Therapeutic DLL4 binding proteins
EP3072904A1 (en) * 2010-03-02 2016-09-28 Abbvie Inc. Therapeutic dll4 binding proteins
KR20130108295A (ko) * 2010-08-13 2013-10-02 베일러 리서치 인스티튜트 항원-제시 세포에 항체에 대한 보조제를 직접 표적화함을 기초로 하는 신규 백신 보조제
US20120128710A1 (en) * 2010-11-02 2012-05-24 Baylor Research Institute Enhancement of Pathogen-Specific Memory Th17 Cell Responses
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
CN103619879A (zh) 2010-12-01 2014-03-05 奥尔德生物控股有限责任公司 抗ngf组合物及其用途
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
AR085633A1 (es) * 2011-03-08 2013-10-16 Baylor Res Inst Coadyuvantes basados en anticuerpos que son dirigidos directamente a las celulas presentadoras en antigenos
US9045542B2 (en) 2011-08-29 2015-06-02 Baylor Research Institute Controlling allergy and asthma by activating human DCs via Dectin-1 or toll-like receptor 2 (TLR2)
US20140037606A1 (en) * 2012-08-06 2014-02-06 Eyal Amiel Cell-based, anti-cancer vaccines
EP3013362B1 (en) 2013-06-28 2021-08-04 Baylor Research Institute Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis
CA2936833A1 (en) 2014-01-13 2015-07-16 Baylor Research Institute Novel vaccines against hpv and hpv-related diseases
WO2015175957A1 (en) 2014-05-16 2015-11-19 Baylor Research Institute Methods and compositions for treating autoimmune and inflammatory conditions
CN106456736A (zh) * 2014-06-02 2017-02-22 贝勒研究院 用于治疗过敏和炎性疾病的方法和组合物
EP3045470A1 (en) 2015-01-15 2016-07-20 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Modulators of the function of the core domain of annexins, and uses thereof in autoimmune and/or cancer therapy
EP3308800B1 (en) * 2015-06-10 2021-08-25 The University of Tokyo Adjuvant for vaccines, vaccine, and immunity induction method
EP3355921A4 (en) * 2015-09-30 2019-05-22 Janssen Biotech, Inc. ANTAGONIST ANTIBODIES SPECIFICALLY BINDING TO HUMAN CD40 AND METHODS OF USE
EP3397263B1 (en) * 2015-12-30 2023-09-20 Celgene Corporation T lymphocyte production methods and t lymphocytes produced thereby
WO2017201635A1 (zh) * 2016-05-23 2017-11-30 蔡胜和 透明质酸酶的细胞表达及其在实体瘤细胞治疗中的应用
EP3468621B1 (en) 2016-06-10 2022-09-21 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts The core domain of annexins and uses thereof in antigen delivery and vaccination
JP7011764B2 (ja) 2016-07-07 2022-01-27 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 抗体アジュバント複合体
CN106148279A (zh) * 2016-07-28 2016-11-23 广州赛莱拉干细胞科技股份有限公司 一种长时间培养b细胞的方法
CN109022431B (zh) * 2018-08-06 2022-02-11 苏州吉玛基因股份有限公司 激活免疫反应的cpg-b型寡核苷酸及其应用
KR20220004634A (ko) 2019-03-15 2022-01-11 볼트 바이오테라퓨틱스 인코퍼레이티드 Her2를 표적으로 하는 면역접합체
US20220177912A1 (en) * 2019-04-12 2022-06-09 The Methodist Hospital Therapeutic particles that enable antigen presenting cells to attack cancer cells
CN111303302A (zh) * 2020-03-19 2020-06-19 芜湖天明生物技术有限公司 一种可溶性高效表达的rChGM-CSF-IFNα融合蛋白及其制备方法和应用
CN113624964A (zh) * 2021-06-29 2021-11-09 上海市第十人民医院 一种侵袭性真菌的检测方法及检测试剂盒

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3949064A (en) * 1973-10-26 1976-04-06 Baxter Laboratories, Inc. Method of detecting antigens or antibodies
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US20040258688A1 (en) * 1995-01-31 2004-12-23 Daniel Hawiger Enhanced antigen delivery and modulation of the immune response therefrom
DK0941315T3 (da) * 1996-11-26 2006-05-15 Stressgen Biotechnologies Corp Fusionsproteiner indeholdende stressproteiner til induktion af immunreaktioner
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
US5945308A (en) * 1998-04-03 1999-08-31 Incyte Pharmaceuticals, Inc. Human oxidized LDL receptor
US6544780B1 (en) * 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
GB0112649D0 (en) * 2001-05-24 2001-07-18 Isis Innovation Macrophage receptor
JPWO2003033695A1 (ja) * 2001-10-11 2005-02-03 片倉工業株式会社 組換え融合タンパク質の精製方法およびこれを利用するタンパク質の製造方法
US20070219149A1 (en) * 2003-08-11 2007-09-20 The Research Foundation For Microbial Diseases Of Osaka University Novel Vaccine Containing Adjuvant Capable Of Inducing Mucosal Immunity
JP4637856B2 (ja) * 2004-11-12 2011-02-23 生化学工業株式会社 抗デクチン−１モノクローナル抗体を産生するハイブリドーマ
US20060135906A1 (en) * 2004-11-16 2006-06-22 Akihiko Matsumura Iontophoretic device and method for administering immune response-enhancing agents and compositions
BRPI0518728A2 (pt) * 2004-12-09 2008-12-02 Univ Pittsburgh vacinas para a resposta rÁpida À pandemia de gripe aviÁria
WO2006082435A1 (en) * 2005-02-04 2006-08-10 Viranative Ab Method and use of interferon compositions for the treatment of avian influenza
KR101916787B1 (ko) * 2005-03-23 2019-01-24 글락소스미스클라인 바이오로지칼즈 에스.에이. Ｃｄ4 ｔ－세포 및/또는 개선된 ｂ－메모리 세포 반응을 유도하는 인플루엔자 바이러스 및 수중유 에멀젼 애주번트의 용도
US7666596B2 (en) * 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
JP2009509540A (ja) * 2005-09-30 2009-03-12 オクラホマ・メディカル・リサーチ・ファウンデーション 幹細胞におけるＴｏｌｌ様受容体の調節
GB0605735D0 (en) * 2006-03-22 2006-05-03 Immunobiology Ltd Composition and method for mediating an immune response
KR20090114425A (ko) * 2007-02-02 2009-11-03 베일러 리서치 인스티튜트 표적화 사람화된 모노클로날 항체와 복합체화된 다가변성 항원
JP5904227B2 (ja) * 2014-03-24 2016-04-13 トヨタ自動車株式会社 エンジンの冷却装置

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