HK1131882A1 - Educated nkt cells and their uses in the treatment of immune-related disorders - Google Patents

Educated nkt cells and their uses in the treatment of immune-related disorders

Info

Publication number
HK1131882A1
HK1131882A1 HK09108172.4A HK09108172A HK1131882A1 HK 1131882 A1 HK1131882 A1 HK 1131882A1 HK 09108172 A HK09108172 A HK 09108172A HK 1131882 A1 HK1131882 A1 HK 1131882A1
Authority
HK
Hong Kong
Prior art keywords
immune
treatment
related disorders
nkt cells
educated nkt
Prior art date
Application number
HK09108172.4A
Other languages
English (en)
Inventor
Yaron Ilan
Maya Margalit
Eran Elinav
Original Assignee
Enzo Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzo Therapeutics Inc filed Critical Enzo Therapeutics Inc
Publication of HK1131882A1 publication Critical patent/HK1131882A1/xx

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46434Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • A61P37/02Immunomodulators
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/53Liver
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
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  • Wood Science & Technology (AREA)
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  • Hematology (AREA)
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  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
HK09108172.4A 2003-09-30 2009-09-07 Educated nkt cells and their uses in the treatment of immune-related disorders HK1131882A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/676,045 US20050069546A1 (en) 2003-09-30 2003-09-30 Educated NKT cells and their uses in the treatment of immune-related disorders
PCT/US2004/030891 WO2005032463A2 (en) 2003-09-30 2004-09-20 Educated nkt cells and their uses in the treatment of immune-related disorders

Publications (1)

Publication Number Publication Date
HK1131882A1 true HK1131882A1 (en) 2010-02-12

Family

ID=34377322

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09108172.4A HK1131882A1 (en) 2003-09-30 2009-09-07 Educated nkt cells and their uses in the treatment of immune-related disorders

Country Status (8)

Country Link
US (1) US20050069546A1 (zh)
EP (6) EP2465526A3 (zh)
JP (1) JP2007533633A (zh)
CN (1) CN101389349B (zh)
CA (1) CA2540672A1 (zh)
HK (1) HK1131882A1 (zh)
IL (1) IL174594A (zh)
WO (1) WO2005032463A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142802A (en) * 2000-04-27 2015-01-29 Enzo Therapeutics Inc Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma
IL140537A0 (en) * 2000-12-25 2002-02-10 Hadasit Med Res Service Educated nk t cells and their uses in the treatment of immune-related disorders
WO2005032462A2 (en) * 2003-02-27 2005-04-14 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
US20130078238A1 (en) * 2010-04-29 2013-03-28 Hadasit Medical Research Services & Decvelopment Co. Ltd. Methods and Compositions for Treating Hepatitis with Anti-CD3 Immune Molecule Therapy
AU2013349706B2 (en) * 2012-11-21 2019-08-22 Assistance Publique - Hopitaux De Paris Methods for determining the risk of acute graft versus host disease
CN105418765B (zh) * 2014-08-26 2019-09-06 西比曼生物科技(上海)有限公司 Cd19靶向性的嵌合抗原受体和nkt细胞及其制法和应用
AU2017321426B2 (en) * 2016-08-29 2022-09-29 Hackensack University Medical Center Methods for treating an immune disorder-related disease by reducing autoreactivity in a T cell compartment
CN114790445B (zh) * 2022-06-22 2022-09-02 北京荟科柘生物科技有限公司 一种cd4-cd8-nkt细胞制备方法及其应用
CN115247149B (zh) * 2022-08-22 2023-06-16 华域生物科技(天津)有限公司 适用于nk细胞的培养基组合物及培养方法

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US447704A (en) * 1891-03-03 Egbert w
US170258A (en) * 1875-11-23 Improvement in sofa-bedsteads
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
CA2252790A1 (en) 1997-02-28 1998-09-03 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (sidr)
JP2003524146A (ja) * 1998-07-09 2003-08-12 ニッコロフ,ブライアン・ジェイ T細胞上のナチュラルキラーレセプターとそれらに対応するリガンドとの相互作用を変調することにより疾患を治療する方法
FR2792205B1 (fr) * 1999-04-19 2001-07-27 Inst Nat Sante Rech Med Composition pharmaceutique comprenant des cellules nkt activees par des pim, et son utilisation en therapie
JP4789311B2 (ja) * 1999-07-16 2011-10-12 エンゾー セラピューティクス, インコーポレイテッド 新規の選択的免疫ダウンレギュレーション(sidr)媒介性移植プロセス、被験体における疾患を予防または処置するためのプロセス、およびsidrを確立するために有用である、馴化またはプログラミングされた細胞、組織または器官を含む組成物
AU2000275584A1 (en) * 2000-01-28 2001-08-07 Orient Cancer Therapy Co., Ltd. Anticancer compositions
US20020031787A1 (en) * 2000-02-04 2002-03-14 Maclaren Noel K. Compositions and methods for reducing autoimmunity
IL142802A (en) 2000-04-27 2015-01-29 Enzo Therapeutics Inc Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma
CA2413866C (en) * 2000-06-19 2014-09-02 Beth Israel Deaconess Medical Center Compositions and methods of monoclonal and polyclonal antibodies specific for t cell subpopulations
EP2027867A1 (en) * 2000-10-20 2009-02-25 Genetics Institute, LLC Method and composition for inhibition of tumor growth and enhancing an immune response
JP2004248504A (ja) * 2000-11-22 2004-09-09 Kirin Brewery Co Ltd Th2型またはTh1型にシフトしたナチュラルキラーT細胞の増幅方法
IL140537A0 (en) * 2000-12-25 2002-02-10 Hadasit Med Res Service Educated nk t cells and their uses in the treatment of immune-related disorders
US20030095965A1 (en) * 2001-05-02 2003-05-22 Katrien Van Beneden Antibodies to Ly49E and CD94/NKG2 receptors
HUP0401156A2 (hu) * 2001-07-20 2004-12-28 Intermune, Inc. Májfibrózis kezelésére szolgáló módszerek
JP2005536982A (ja) * 2001-11-07 2005-12-08 麒麟麦酒株式会社 インビトロにおけるt細胞増幅および増幅されたt細胞集団

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Publication number Publication date
EP2465528A3 (en) 2012-09-05
EP1675549A4 (en) 2009-06-17
WO2005032463A3 (en) 2008-10-16
EP2465528A2 (en) 2012-06-20
EP2465525A3 (en) 2012-08-29
JP2007533633A (ja) 2007-11-22
US20050069546A1 (en) 2005-03-31
EP2465525A2 (en) 2012-06-20
EP2465529A2 (en) 2012-06-20
EP2465526A2 (en) 2012-06-20
EP2465526A3 (en) 2012-08-29
CN101389349A (zh) 2009-03-18
IL174594A (en) 2010-12-30
EP1675549A2 (en) 2006-07-05
CN101389349B (zh) 2012-09-05
WO2005032463A2 (en) 2005-04-14
IL174594A0 (en) 2006-08-20
EP2465527A2 (en) 2012-06-20
EP2465527A3 (en) 2012-09-12
EP2465529A3 (en) 2012-09-05
CA2540672A1 (en) 2005-04-14

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