HK1129096A1 - 適用作電壓-門控鈉通道抑制劑的組合物 - Google Patents

適用作電壓-門控鈉通道抑制劑的組合物

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Publication number
HK1129096A1
HK1129096A1 HK09107322.5A HK09107322A HK1129096A1 HK 1129096 A1 HK1129096 A1 HK 1129096A1 HK 09107322 A HK09107322 A HK 09107322A HK 1129096 A1 HK1129096 A1 HK 1129096A1
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HK
Hong Kong
Prior art keywords
inhibitors
compositions useful
sodium channels
gated sodium
voltage gated
Prior art date
Application number
HK09107322.5A
Other languages
English (en)
Inventor
．約什
．克任尼特斯奇
．岡扎勒茲
王堅
．威爾森
．特明
Original Assignee
沃泰克斯藥物股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 沃泰克斯藥物股份有限公司 filed Critical 沃泰克斯藥物股份有限公司
Publication of HK1129096A1 publication Critical patent/HK1129096A1/zh

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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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HK09107322.5A 2006-04-11 2009-08-10 適用作電壓-門控鈉通道抑制劑的組合物 HK1129096A1 (zh)

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MX2008013194A (es) 2008-12-01
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NO20084758L (no) 2009-01-09
CA2648202A1 (en) 2007-10-25
AU2007238857B2 (en) 2013-05-02
RU2008144415A (ru) 2010-05-20
RU2470012C2 (ru) 2012-12-20
KR20080109918A (ko) 2008-12-17
WO2007120647A3 (en) 2007-11-29
US8841483B2 (en) 2014-09-23
US20070238733A1 (en) 2007-10-11
WO2007120647A2 (en) 2007-10-25
JP5438504B2 (ja) 2014-03-12

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