HK1128727A1 - Chimaeric fusion protein with superior chaperone and folding activities - Google Patents

Chimaeric fusion protein with superior chaperone and folding activities

Info

Publication number
HK1128727A1
HK1128727A1 HK09106413.7A HK09106413A HK1128727A1 HK 1128727 A1 HK1128727 A1 HK 1128727A1 HK 09106413 A HK09106413 A HK 09106413A HK 1128727 A1 HK1128727 A1 HK 1128727A1
Authority
HK
Hong Kong
Prior art keywords
fusion protein
nucleotide sequences
protein
sequences coding
chimeric fusion
Prior art date
Application number
HK09106413.7A
Other languages
English (en)
Inventor
Christian Scholz
Peter Schaarschmidt
Urban Schmitt
Elke Faatz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1128727A1 publication Critical patent/HK1128727A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK09106413.7A 2006-01-03 2009-07-15 Chimaeric fusion protein with superior chaperone and folding activities HK1128727A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06000056 2006-01-03
EP06009106 2006-05-03
PCT/EP2006/012599 WO2007077008A1 (en) 2006-01-03 2006-12-29 Chimaeric fusion protein with superior chaperone and folding activities

Publications (1)

Publication Number Publication Date
HK1128727A1 true HK1128727A1 (en) 2009-11-06

Family

ID=37908055

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09106413.7A HK1128727A1 (en) 2006-01-03 2009-07-15 Chimaeric fusion protein with superior chaperone and folding activities

Country Status (9)

Country Link
US (2) US7947494B2 (xx)
EP (1) EP1971684B1 (xx)
JP (1) JP4871960B2 (xx)
CN (1) CN101351550B (xx)
AT (1) ATE527345T1 (xx)
CA (1) CA2636075C (xx)
ES (1) ES2375863T3 (xx)
HK (1) HK1128727A1 (xx)
WO (1) WO2007077008A1 (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127678A1 (en) 2008-05-26 2009-12-02 Roche Diagnostics GmbH SlpA as a tool for recombinant protein and enzyme technology
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
EP2706115A1 (en) * 2012-09-06 2014-03-12 Roche Diagnostics GmbH Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays
EP2917243B1 (en) * 2012-11-08 2018-03-14 F.Hoffmann-La Roche Ag Her3 antigen binding proteins binding to the beta-hairpin of her3
US9725511B2 (en) * 2012-11-08 2017-08-08 Hoffmann-La Roche Inc. Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4
US20190292535A1 (en) 2012-11-08 2019-09-26 Roche Diagnostics Operations, Inc. Nucleic acids encoding chimeric polypeptides for library screening
EP3049437A1 (en) * 2013-09-27 2016-08-03 F. Hoffmann-La Roche AG Thermus thermophilus slyd fkbp domain specific antibodies
WO2016004024A1 (en) 2014-07-02 2016-01-07 Sutro Biopharma, Inc. High growth capacity auxotrophic escherichia coli and methods of use
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
WO2016129637A1 (ja) * 2015-02-13 2016-08-18 積水化学工業株式会社 核酸、融合タンパク質、組換え細胞、並びに、イソプレン又は環式テルペンの生産方法
CN108699104B (zh) * 2015-12-15 2022-07-15 豪夫迈·罗氏有限公司 具有转谷氨酰胺酶识别位点的fkbp结构域
EP3443001A4 (en) 2016-04-11 2020-04-29 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
CN107522787A (zh) * 2016-06-15 2017-12-29 中国科学院上海生命科学研究院 在细胞内产生点突变的融合蛋白、其制备及用途
WO2018161038A1 (en) * 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il12 compositions and methods for immunotherapy
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
BR112019020967A2 (pt) * 2017-04-05 2020-05-05 Revolution Medicines Inc métodos e reagentes para analisar interfaces de proteína-proteína
JP7438545B2 (ja) * 2018-05-31 2024-02-27 トラスティーズ・オヴ・ダートマス・カレッジ ３次又は４次構造モチーフを用いた計算タンパク質設計
EP3956344A1 (en) * 2019-04-16 2022-02-23 University of Washington Amantadine binding protein
WO2023213758A1 (en) * 2022-05-03 2023-11-09 F. Hoffmann-La Roche Ag Hiv gp41 variants for immunodiagnostic assays

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11513246A (ja) 1995-09-15 1999-11-16 メルク エンド カンパニー インコーポレーテッド 融合タンパク質を用いるハイスループットアッセイ
US5989868A (en) 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
US7094884B2 (en) * 2001-06-22 2006-08-22 Roche Diagnostics Corporation Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them
US6962982B2 (en) * 2001-06-22 2005-11-08 Roche Diagnostics Corporation Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them
AU2002317841A1 (en) * 2001-06-22 2003-01-08 Roche Diagnostics Gmbh Use of fkbp chaperones as expression tool
US7094757B2 (en) * 2001-06-22 2006-08-22 Roche Diagnostics Corporation Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them
CA2490384A1 (en) 2002-06-25 2003-12-31 Sekisui Chemical Co., Ltd. Expression vector, host, fused protein, process for producing fused protein and process for producing protein
US20070026501A1 (en) * 2003-04-18 2007-02-01 Joe Chiba Immunogen, composition for immulogical use and process for producing antibody using the same
US7604935B2 (en) * 2005-10-26 2009-10-20 Roche Diagnostics Operations, Inc. Soluble rubella E1 envelope protein variants

Also Published As

Publication number Publication date
US20110189754A1 (en) 2011-08-04
CA2636075A1 (en) 2007-07-12
CA2636075C (en) 2011-11-08
ES2375863T3 (es) 2012-03-07
JP2009521938A (ja) 2009-06-11
US8247206B2 (en) 2012-08-21
US20090042251A1 (en) 2009-02-12
EP1971684B1 (en) 2011-10-05
CN101351550A (zh) 2009-01-21
EP1971684A1 (en) 2008-09-24
JP4871960B2 (ja) 2012-02-08
WO2007077008A1 (en) 2007-07-12
ATE527345T1 (de) 2011-10-15
US7947494B2 (en) 2011-05-24
CN101351550B (zh) 2012-10-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20161229