HK1128458A1 - - Google Patents

Info

Publication number
HK1128458A1
HK1128458A1 HK09107578.6A HK09107578A HK1128458A1 HK 1128458 A1 HK1128458 A1 HK 1128458A1 HK 09107578 A HK09107578 A HK 09107578A HK 1128458 A1 HK1128458 A1 HK 1128458A1
Authority
HK
Hong Kong
Application number
HK09107578.6A
Inventor
Piaoyang Sun
Yongjiang Chen
Guangliang Yu
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of HK1128458A1 publication Critical patent/HK1128458A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK09107578.6A 2007-11-16 2009-08-18 HK1128458A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200710188301 2007-11-16

Publications (1)

Publication Number Publication Date
HK1128458A1 true HK1128458A1 (zh) 2009-10-30

Family

ID=40709206

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09107578.6A HK1128458A1 (zh) 2007-11-16 2009-08-18

Country Status (7)

Country Link
US (1) US8198485B2 (zh)
EP (1) EP2213651B1 (zh)
JP (1) JP5503546B2 (zh)
CN (1) CN101434552B (zh)
HK (1) HK1128458A1 (zh)
TW (1) TWI398427B (zh)
WO (1) WO2009062377A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010072409A1 (en) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine
EP2902384B1 (en) 2010-02-12 2017-11-08 KRKA, D.D., Novo Mesto Form of ivabradine hydrochloride
CN101857549B (zh) * 2010-06-22 2013-04-10 浙江美诺华药物化学有限公司 (1s)-4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的合成方法
CN102070470A (zh) * 2010-11-05 2011-05-25 天津药物研究院 制备s(-)2-(n-正丙基)胺基-5-甲氧基四氢萘的方法
ITMI20111467A1 (it) * 2011-08-01 2013-02-02 Laboratorio Chimico Int Spa Procedimento per la preparazione di ivabradina e di suoi intermedi di sintesi
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
CN102827080B (zh) * 2012-09-12 2014-03-19 江苏宇田生物医药科技有限公司 一种伊伐布雷定的合成方法及其中间产物
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN114324714B (zh) * 2021-01-05 2023-06-30 海南鑫开源医药科技有限公司 (1s)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐的检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
GB9826540D0 (en) * 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
AU2003289487A1 (en) * 2003-01-16 2004-08-10 Toray Fine Chemicals Co, . Ltd. Processes for the recovery of optically active diacyltartatic acids
CN100475774C (zh) * 2003-09-28 2009-04-08 中国人民解放军军事医学科学院毒物药物研究所 D-（+）-或l-（-）-酒石酸或其衍生物作为dl-麻黄碱或其衍生物的拆分剂及其拆分方法
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
TW200951102A (en) 2009-12-16
TWI398427B (zh) 2013-06-11
CN101434552B (zh) 2012-05-23
EP2213651A4 (en) 2012-03-07
JP5503546B2 (ja) 2014-05-28
JP2011503122A (ja) 2011-01-27
EP2213651A1 (en) 2010-08-04
US8198485B2 (en) 2012-06-12
WO2009062377A1 (fr) 2009-05-22
EP2213651B1 (en) 2012-12-19
CN101434552A (zh) 2009-05-20
US20120004463A1 (en) 2012-01-05

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220524