HK1125631A1 - Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors - Google Patents
Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitorsInfo
- Publication number
- HK1125631A1 HK1125631A1 HK09104027.0A HK09104027A HK1125631A1 HK 1125631 A1 HK1125631 A1 HK 1125631A1 HK 09104027 A HK09104027 A HK 09104027A HK 1125631 A1 HK1125631 A1 HK 1125631A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compositions
- methods
- kinase inhibitors
- aurora kinase
- benzazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77249706P | 2006-02-10 | 2006-02-10 | |
| US79118706P | 2006-04-11 | 2006-04-11 | |
| PCT/US2007/003579 WO2007095124A2 (fr) | 2006-02-10 | 2007-02-09 | Derives, compositions de benzazole et procedes d'utilisation en tant qu'inhibiteurs de la kinase aurora |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1125631A1 true HK1125631A1 (en) | 2009-08-14 |
Family
ID=38157823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09104027.0A HK1125631A1 (en) | 2006-02-10 | 2009-04-30 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7820821B2 (fr) |
| EP (2) | EP1987028A2 (fr) |
| JP (1) | JP5188988B2 (fr) |
| CN (2) | CN102633783A (fr) |
| AU (1) | AU2007215247B2 (fr) |
| BR (1) | BRPI0708034A2 (fr) |
| CA (1) | CA2641744C (fr) |
| HK (1) | HK1125631A1 (fr) |
| IL (1) | IL192580A0 (fr) |
| WO (1) | WO2007095124A2 (fr) |
Families Citing this family (55)
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| EP2457901A1 (fr) * | 2005-03-14 | 2012-05-30 | High Point Pharmaceuticals, LLC | Dérivés de benzazole, compositions et procédés d'utilisation en tant qu'inhibiteurs de secrétase B |
| ES2614090T3 (es) | 2005-12-29 | 2017-05-29 | Celtaxsys, Inc. | Derivados de diamina como inhibidores de leucotrieno A4 hidrolasa |
| NZ585139A (en) * | 2007-11-16 | 2012-05-25 | Incyte Corp | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as jak inhibitors |
| WO2009084008A1 (fr) * | 2007-12-28 | 2009-07-09 | Cadila Healthcare Limited | Procédé de préparation de mycophénolate mofétil |
| US8344018B2 (en) | 2008-07-14 | 2013-01-01 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
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| AU2009296820B2 (en) | 2008-09-26 | 2014-03-20 | Merck Sharp & Dohme Llc | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
| US8563746B2 (en) | 2008-10-29 | 2013-10-22 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
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| WO2010074724A1 (fr) * | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Inhibiteurs d'aurora kinases associés avec des anticorps anti-cd20 |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
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| EP2483407A2 (fr) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Procédés de modulation de l'autophagie par la modulation de produits géniques renforçant l'autophagie |
| DK2536285T3 (en) * | 2010-02-18 | 2018-07-16 | Vtv Therapeutics Llc | Substituted fused imidazole derivatives, pharmaceutical compositions and methods for their use |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
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| US8759537B2 (en) * | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| EP2869897A4 (fr) | 2012-07-06 | 2016-09-28 | Univ Duke | Activation du canal ionique trpv4 par stimuli physiques et rôle critique de trpv4 dans l'inflammation et la démangeaison spécifique à un organe |
| EP2935302B1 (fr) | 2012-12-18 | 2018-06-06 | Vertex Pharmaceuticals Incorporated | Dérivés de mannose pour le traitement d'infections bactériennes |
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| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
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| BR112015022227A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
| RU2678196C2 (ru) | 2013-03-14 | 2019-01-24 | Селтакссис, Инк. | Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы |
| WO2014193696A2 (fr) * | 2013-05-28 | 2014-12-04 | Transtech Pharma, Llc | Dérivés d'acide benzimidazole-carboxylique, compositions et procédés d'utilisation en tant qu'inhibiteurs de kinase aurora |
| TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| SG11201605408RA (en) | 2014-01-10 | 2016-07-28 | Aurigene Discovery Tech Ltd | Indazole compounds as irak4 inhibitors |
| DK3094329T3 (en) | 2014-01-13 | 2018-11-19 | Aurigene Discovery Tech Ltd | BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAC4 INHIBITORS |
| BR112016029853A2 (pt) * | 2014-06-20 | 2017-08-22 | Aurigene Discovery Tech Ltd | compostos de indazol substituído como inibidores de irak4 |
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| US11229628B2 (en) | 2015-01-09 | 2022-01-25 | Duke University | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch |
| CA3025145A1 (fr) * | 2015-05-22 | 2016-12-01 | Translational Drug Development Llc | Compositions de compose actif et benzamide et leurs methodes d'utilisation |
| JP6802194B2 (ja) | 2015-06-22 | 2020-12-16 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｎａｄｐｈオキシダーゼ４阻害剤 |
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| CN115594671B (zh) * | 2021-07-08 | 2024-03-15 | 沈阳药科大学 | 苯并噻唑类衍生物及其制备方法和用途 |
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| GB0311201D0 (en) * | 2003-05-15 | 2003-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| ES2374272T3 (es) * | 2003-06-19 | 2012-02-15 | Glaxosmithkline Llc | Derivados de 5-(acilamino)indazol como inhibidores de quinasas. |
| US20060205740A1 (en) * | 2003-08-14 | 2006-09-14 | Reno Michael J | Chemical compounds |
| WO2005035526A1 (fr) | 2003-10-09 | 2005-04-21 | Argenta Discovery Ltd. | Composes bicycliques et leur utilisation therapeutique |
| CA2542653A1 (fr) * | 2003-10-16 | 2005-04-28 | Chiron Corporation | Benzazoles substitues et leur utilisation en tant qu'inhibiteurs de la raf kinase |
| DE10349587A1 (de) | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| US7470712B2 (en) * | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| WO2005090379A1 (fr) | 2004-03-17 | 2005-09-29 | The Central Science Laboratory, 'csl' | Composes et capteurs destines a la detection d'hydrocarbures aromatiques polycycliques |
| US20060019967A1 (en) * | 2004-07-21 | 2006-01-26 | Su-Ying Wu | SARS CoV main protease inhibitors |
| US20060068998A1 (en) * | 2004-09-27 | 2006-03-30 | Fuji Photo Film Co. Ltd. | Lubricant composition and triazine ring-containing compound |
| ES2316053T3 (es) * | 2005-02-10 | 2009-04-01 | Smithkline Beecham Corporation | Compuestos de piridopirazolopirimidina y sus usos como farmacos contra el cancer y contra la diabetes. |
| EP2457901A1 (fr) * | 2005-03-14 | 2012-05-30 | High Point Pharmaceuticals, LLC | Dérivés de benzazole, compositions et procédés d'utilisation en tant qu'inhibiteurs de secrétase B |
| JP5193876B2 (ja) * | 2005-12-02 | 2013-05-08 | バイエル・ヘルスケア・エルエルシー | オーロラキナーゼの阻害により癌を処置するために有用なピロロトリアジン誘導体 |
-
2007
- 2007-02-09 CN CN2012101215887A patent/CN102633783A/zh active Pending
- 2007-02-09 EP EP07750418A patent/EP1987028A2/fr not_active Withdrawn
- 2007-02-09 EP EP10194622A patent/EP2295432A1/fr not_active Withdrawn
- 2007-02-09 US US11/704,431 patent/US7820821B2/en not_active Expired - Fee Related
- 2007-02-09 WO PCT/US2007/003579 patent/WO2007095124A2/fr active Application Filing
- 2007-02-09 CN CN2007800047858A patent/CN101379060B/zh not_active Expired - Fee Related
- 2007-02-09 BR BRPI0708034-4A patent/BRPI0708034A2/pt not_active IP Right Cessation
- 2007-02-09 JP JP2008554398A patent/JP5188988B2/ja not_active Expired - Fee Related
- 2007-02-09 AU AU2007215247A patent/AU2007215247B2/en not_active Ceased
- 2007-02-09 CA CA2641744A patent/CA2641744C/fr not_active Expired - Fee Related
-
2008
- 2008-07-02 IL IL192580A patent/IL192580A0/en unknown
-
2009
- 2009-04-30 HK HK09104027.0A patent/HK1125631A1/xx not_active IP Right Cessation
-
2010
- 2010-02-10 US US12/703,604 patent/US8377983B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7820821B2 (en) | 2010-10-26 |
| JP2009526072A (ja) | 2009-07-16 |
| JP5188988B2 (ja) | 2013-04-24 |
| CA2641744A1 (fr) | 2007-08-23 |
| CA2641744C (fr) | 2012-09-25 |
| IL192580A0 (en) | 2009-02-11 |
| US8377983B2 (en) | 2013-02-19 |
| CN101379060A (zh) | 2009-03-04 |
| US20070219235A1 (en) | 2007-09-20 |
| AU2007215247A1 (en) | 2007-08-23 |
| WO2007095124A2 (fr) | 2007-08-23 |
| WO2007095124A3 (fr) | 2007-11-01 |
| AU2007215247B2 (en) | 2012-12-13 |
| EP2295432A1 (fr) | 2011-03-16 |
| BRPI0708034A2 (pt) | 2011-05-17 |
| CN102633783A (zh) | 2012-08-15 |
| CN101379060B (zh) | 2012-05-23 |
| US20100152170A1 (en) | 2010-06-17 |
| EP1987028A2 (fr) | 2008-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170209 |