HK1121737A1 - Piperidine derivatives useful as histamine h3 antagonists - Google Patents
Piperidine derivatives useful as histamine h3 antagonistsInfo
- Publication number
- HK1121737A1 HK1121737A1 HK08110560.1A HK08110560A HK1121737A1 HK 1121737 A1 HK1121737 A1 HK 1121737A1 HK 08110560 A HK08110560 A HK 08110560A HK 1121737 A1 HK1121737 A1 HK 1121737A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- histamine
- antagonists
- derivatives useful
- piperidine derivatives
- piperidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69211005P | 2005-06-20 | 2005-06-20 | |
PCT/US2006/023800 WO2007001975A1 (fr) | 2005-06-20 | 2006-06-19 | Dérivés de la pipéridine utiles comme antagonistes du récepteur h3 de l'histamine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1121737A1 true HK1121737A1 (en) | 2009-04-30 |
Family
ID=36968725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08110560.1A HK1121737A1 (en) | 2005-06-20 | 2008-09-23 | Piperidine derivatives useful as histamine h3 antagonists |
Country Status (17)
Country | Link |
---|---|
US (2) | US7635705B2 (fr) |
EP (1) | EP1902046B1 (fr) |
JP (1) | JP2008546784A (fr) |
KR (1) | KR20080021082A (fr) |
CN (1) | CN101243072A (fr) |
AR (1) | AR054787A1 (fr) |
AT (1) | ATE450526T1 (fr) |
AU (1) | AU2006262441A1 (fr) |
CA (1) | CA2610959A1 (fr) |
DE (1) | DE602006010870D1 (fr) |
ES (1) | ES2337727T3 (fr) |
HK (1) | HK1121737A1 (fr) |
IL (1) | IL187984A0 (fr) |
MX (1) | MX2008000115A (fr) |
TW (1) | TW200738676A (fr) |
WO (1) | WO2007001975A1 (fr) |
ZA (1) | ZA200710968B (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
US20070142369A1 (en) * | 2005-12-21 | 2007-06-21 | Margaret Van Heek | Combination of an H3 antagonist/inverse agonist and an appetite suppressant |
EA200900539A1 (ru) * | 2006-10-20 | 2009-10-30 | Эрет Терэпьютикс, Инк. | Соединения фенилмочевины (варианты), содержащая их фармацевтическая композиция и способ лечения заболеваний, опосредованных растворимой эпоксидгидролазой (варианты) |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
KR20090111319A (ko) * | 2007-01-29 | 2009-10-26 | 아레테 테라퓨틱스 인코퍼레이티드 | 대사 증후군 및 관련 장애의 치료를 위한 가용성 에폭시드 히드롤라아제 억제제 |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
US20100093692A1 (en) * | 2007-03-02 | 2010-04-15 | Schering Corporation Sechering-Plough Corporation | Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain |
US20080227780A1 (en) * | 2007-03-13 | 2008-09-18 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
JP5431306B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのチア(ジア)ゾール |
MX2009011415A (es) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. |
CA2685029A1 (fr) * | 2007-04-26 | 2008-11-06 | Avalon Pharmaceuticals | Composes polycycliques et leurs utilisations |
GB0713686D0 (en) | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
RU2502734C2 (ru) | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
US20110166124A1 (en) | 2008-07-23 | 2011-07-07 | Mccormick Kevin D | Tricyclic spirocycle derivatives and methods of use |
JP5457450B2 (ja) | 2008-07-31 | 2014-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 迅速解離性ドーパミン2受容体拮抗薬としてのピペラジン−1−イル−トリフルオロメチル−置換−ピリジン |
EP2404902A1 (fr) * | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Dérivés de la pipéridine et de la pyrrolidine dotés d'un antagonisme pour les récepteurs npy y5 |
US8337835B2 (en) * | 2009-04-10 | 2012-12-25 | Washington University | Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders |
PL2527340T3 (pl) * | 2010-01-22 | 2017-01-31 | Taiho Pharmaceutical Co., Ltd. | Związek piperazynowy wykazujący efekt hamowania pgds |
WO2011153359A1 (fr) | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Inhibiteurs du transporteur 1 de la glycine, procédés de fabrication associés, et utilisations associées |
WO2012094437A2 (fr) * | 2011-01-07 | 2012-07-12 | Targacept, Inc. | Antagonistes non-compétitifs des récepteurs nicotiniques |
US8865641B2 (en) * | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
ES2869884T3 (es) | 2011-09-16 | 2021-10-26 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y la enfermedad de hígado graso no alcohólico |
WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
CN102657868A (zh) * | 2012-05-30 | 2012-09-12 | 中国药科大学 | 5-羟色胺2受体拮抗剂或转运体抑制剂治疗脂肪肝或高脂血症 |
MX2014014979A (es) | 2012-06-06 | 2015-06-17 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de las enfermedades asociadas con la sintasa de oxido nitrico inducible elevada. |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
CN109082465A (zh) * | 2018-08-20 | 2018-12-25 | 苏州市广济医院 | 奥氮平诱导糖代谢紊乱相关疾病的分子标志物及其用途 |
WO2020205867A1 (fr) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Composés ciblant prmt5 |
WO2021187605A1 (fr) * | 2020-03-19 | 2021-09-23 | 田辺三菱製薬株式会社 | Composé hétérocyclique carbonylé à fonction cyano en alpha contenant de l'azote |
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2006
- 2006-06-19 WO PCT/US2006/023800 patent/WO2007001975A1/fr active Application Filing
- 2006-06-19 AT AT06773528T patent/ATE450526T1/de not_active IP Right Cessation
- 2006-06-19 AU AU2006262441A patent/AU2006262441A1/en not_active Abandoned
- 2006-06-19 ES ES06773528T patent/ES2337727T3/es active Active
- 2006-06-19 JP JP2008518276A patent/JP2008546784A/ja not_active Withdrawn
- 2006-06-19 KR KR1020077030855A patent/KR20080021082A/ko not_active Application Discontinuation
- 2006-06-19 MX MX2008000115A patent/MX2008000115A/es active IP Right Grant
- 2006-06-19 CN CNA2006800301178A patent/CN101243072A/zh active Pending
- 2006-06-19 TW TW095121918A patent/TW200738676A/zh unknown
- 2006-06-19 DE DE602006010870T patent/DE602006010870D1/de active Active
- 2006-06-19 CA CA002610959A patent/CA2610959A1/fr not_active Abandoned
- 2006-06-19 US US11/455,625 patent/US7635705B2/en not_active Expired - Fee Related
- 2006-06-19 EP EP06773528A patent/EP1902046B1/fr active Active
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AU2006262441A1 (en) | 2007-01-04 |
IL187984A0 (en) | 2008-03-20 |
CN101243072A (zh) | 2008-08-13 |
DE602006010870D1 (de) | 2010-01-14 |
EP1902046A1 (fr) | 2008-03-26 |
ATE450526T1 (de) | 2009-12-15 |
JP2008546784A (ja) | 2008-12-25 |
AR054787A1 (es) | 2007-07-18 |
CA2610959A1 (fr) | 2007-01-04 |
US7635705B2 (en) | 2009-12-22 |
US7846946B2 (en) | 2010-12-07 |
KR20080021082A (ko) | 2008-03-06 |
WO2007001975A8 (fr) | 2008-01-24 |
US20090286830A1 (en) | 2009-11-19 |
TW200738676A (en) | 2007-10-16 |
EP1902046B1 (fr) | 2009-12-02 |
ES2337727T3 (es) | 2010-04-28 |
ZA200710968B (en) | 2009-03-25 |
WO2007001975A1 (fr) | 2007-01-04 |
MX2008000115A (es) | 2008-03-18 |
US20070015807A1 (en) | 2007-01-18 |
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