HK1106227A1 - Crystalline form of a biphenyl compound - Google Patents
Crystalline form of a biphenyl compoundInfo
- Publication number
- HK1106227A1 HK1106227A1 HK07111424.6A HK07111424A HK1106227A1 HK 1106227 A1 HK1106227 A1 HK 1106227A1 HK 07111424 A HK07111424 A HK 07111424A HK 1106227 A1 HK1106227 A1 HK 1106227A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- salt
- crystalline form
- biphenyl compound
- hydroxy
- biphenyl
- Prior art date
Links
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- -1 biphenyl compound Chemical class 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- 208000019693 Lung disease Diseases 0.000 abstract 1
- URWYQGVSPQJGGB-DHUJRADRSA-N [1-[3-[2-chloro-4-[[[(2r)-2-hydroxy-2-(8-hydroxy-2-oxo-1h-quinolin-5-yl)ethyl]amino]methyl]-5-methoxyanilino]-3-oxopropyl]piperidin-4-yl] n-(2-phenylphenyl)carbamate Chemical compound ClC=1C=C(CNC[C@H](O)C=2C=3C=CC(=O)NC=3C(O)=CC=2)C(OC)=CC=1NC(=O)CCN(CC1)CCC1OC(=O)NC1=CC=CC=C1C1=CC=CC=C1 URWYQGVSPQJGGB-DHUJRADRSA-N 0.000 abstract 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical class OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60180504P | 2004-08-16 | 2004-08-16 | |
PCT/US2005/029013 WO2006023454A1 (en) | 2004-08-16 | 2005-08-15 | Crystalline form of a biphenyl compound |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1106227A1 true HK1106227A1 (en) | 2008-03-07 |
Family
ID=35687428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07111424.6A HK1106227A1 (en) | 2004-08-16 | 2007-10-23 | Crystalline form of a biphenyl compound |
Country Status (26)
Country | Link |
---|---|
US (4) | US7521558B2 (ja) |
EP (1) | EP1778672B1 (ja) |
JP (2) | JP5032990B2 (ja) |
KR (1) | KR101363352B1 (ja) |
CN (1) | CN101006077B (ja) |
AR (1) | AR051003A1 (ja) |
AU (1) | AU2005277601B2 (ja) |
BR (1) | BRPI0514413C1 (ja) |
CA (1) | CA2575874C (ja) |
DK (1) | DK1778672T3 (ja) |
ES (1) | ES2400958T3 (ja) |
HK (1) | HK1106227A1 (ja) |
HR (1) | HRP20130192T1 (ja) |
IL (1) | IL180853A (ja) |
MA (1) | MA28825B1 (ja) |
MX (1) | MX2007001688A (ja) |
MY (1) | MY141224A (ja) |
NO (1) | NO338770B1 (ja) |
NZ (1) | NZ552796A (ja) |
PL (1) | PL1778672T3 (ja) |
PT (1) | PT1778672E (ja) |
RU (1) | RU2381223C2 (ja) |
SI (1) | SI1778672T1 (ja) |
TW (1) | TWI374883B (ja) |
WO (1) | WO2006023454A1 (ja) |
ZA (1) | ZA200701057B (ja) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
US8429052B2 (en) * | 2005-07-19 | 2013-04-23 | Lincoln National Life Insurance Company | Method and system for providing employer-sponsored retirement plan |
GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
AU2007303909A1 (en) * | 2006-10-04 | 2008-04-10 | Pfizer Limited | Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists |
ES2302447B1 (es) * | 2006-10-20 | 2009-06-12 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
ES2306595B1 (es) | 2007-02-09 | 2009-09-11 | Laboratorios Almirall S.A. | Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2. |
ES2320961B1 (es) * | 2007-11-28 | 2010-03-17 | Laboratorios Almirall, S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2. |
EP2096105A1 (en) * | 2008-02-28 | 2009-09-02 | Laboratorios Almirall, S.A. | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor |
UY32297A (es) | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
EP2228368A1 (en) | 2009-03-12 | 2010-09-15 | Almirall, S.A. | Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one |
US8519138B2 (en) | 2009-04-14 | 2013-08-27 | Glaxo Group Limited | Process for the preparation of a biphenyl-2-yl carbamic acid ester |
CA2758505C (en) | 2009-04-23 | 2017-03-07 | Theravance, Inc. | Diamide compounds having muscarinic receptor antagonist and .beta.2 adrenergic receptor agonist activity |
AU2015234331B2 (en) * | 2009-04-23 | 2017-08-03 | Theravance Biopharma R&D Ip, Llc | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
AR083115A1 (es) | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
EP2578570A1 (en) | 2011-10-07 | 2013-04-10 | Almirall, S.A. | Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis. |
KR101993436B1 (ko) * | 2011-10-31 | 2019-06-26 | 노바르티스 아게 | 파조파닙 제형 |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
CN105142673B8 (zh) | 2012-12-18 | 2018-02-16 | 阿尔米雷尔有限公司 | 具有β2肾上腺素能激动剂及M3毒蕈碱拮抗剂活性的新型环己基和奎宁环基氨基甲酸酯衍生物 |
TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有maba化合物和皮質類固醇之組合 |
TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽 |
TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物 |
TW201835041A (zh) | 2017-02-17 | 2018-10-01 | 印度商托仁特生技有限公司 | 具β-腎上腺素促效劑及抗蕈毒活性化合物 |
US11484531B2 (en) | 2018-08-30 | 2022-11-01 | Theravance Biopharma R&D Ip, Llc | Methods for treating chronic obstructive pulmonary disease |
WO2022175982A1 (en) * | 2021-02-19 | 2022-08-25 | Gbr Laboratories Private Limited | A process for preparing batefenterol and intermediates thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS596860B2 (ja) * | 1975-05-19 | 1984-02-15 | オオツカセイヤク カブシキガイシヤ | 5−〔(2−アルキルアミノ−1−ヒドロキシ)アルキル〕カルボスチリル誘導体の製造法 |
US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
AU783095B2 (en) * | 1999-12-07 | 2005-09-22 | Theravance Biopharma R&D Ip, Llc | Carbamate derivatives having muscarinic receptor antagonist activity |
UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
WO2003042160A1 (en) * | 2001-11-13 | 2003-05-22 | Theravance, Inc. | Aryl aniline beta-2 adrenergic receptor agonists |
PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
JP2004356517A (ja) | 2003-05-30 | 2004-12-16 | Ebara Corp | 基板洗浄装置及び基板洗浄方法 |
US20050025718A1 (en) * | 2003-07-31 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
WO2005080375A1 (en) * | 2004-02-13 | 2005-09-01 | Theravance, Inc. | Crystalline form of a biphenyl compound |
TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
-
2005
- 2005-08-03 TW TW094126435A patent/TWI374883B/zh active
- 2005-08-08 AR ARP050103308A patent/AR051003A1/es active IP Right Grant
- 2005-08-15 DK DK05803280.6T patent/DK1778672T3/da active
- 2005-08-15 RU RU2007109598/04A patent/RU2381223C2/ru active
- 2005-08-15 CN CN2005800281254A patent/CN101006077B/zh active Active
- 2005-08-15 ES ES05803280T patent/ES2400958T3/es active Active
- 2005-08-15 JP JP2007527919A patent/JP5032990B2/ja not_active Expired - Fee Related
- 2005-08-15 EP EP05803280A patent/EP1778672B1/en active Active
- 2005-08-15 BR BRPI0514413A patent/BRPI0514413C1/pt not_active IP Right Cessation
- 2005-08-15 SI SI200531675T patent/SI1778672T1/sl unknown
- 2005-08-15 MY MYPI20053814A patent/MY141224A/en unknown
- 2005-08-15 WO PCT/US2005/029013 patent/WO2006023454A1/en active Application Filing
- 2005-08-15 KR KR1020077005834A patent/KR101363352B1/ko active IP Right Grant
- 2005-08-15 PT PT58032806T patent/PT1778672E/pt unknown
- 2005-08-15 AU AU2005277601A patent/AU2005277601B2/en not_active Ceased
- 2005-08-15 MX MX2007001688A patent/MX2007001688A/es active IP Right Grant
- 2005-08-15 PL PL05803280T patent/PL1778672T3/pl unknown
- 2005-08-15 NZ NZ552796A patent/NZ552796A/en not_active IP Right Cessation
- 2005-08-15 US US11/204,065 patent/US7521558B2/en active Active
- 2005-08-15 CA CA2575874A patent/CA2575874C/en active Active
-
2007
- 2007-01-22 IL IL180853A patent/IL180853A/en active IP Right Grant
- 2007-02-05 ZA ZA200701057A patent/ZA200701057B/xx unknown
- 2007-02-23 MA MA29717A patent/MA28825B1/fr unknown
- 2007-03-09 NO NO20071307A patent/NO338770B1/no unknown
- 2007-10-23 HK HK07111424.6A patent/HK1106227A1/xx not_active IP Right Cessation
-
2009
- 2009-02-11 US US12/369,605 patent/US8101766B2/en not_active Expired - Fee Related
-
2011
- 2011-12-16 US US13/328,386 patent/US8476299B2/en active Active
-
2012
- 2012-03-22 JP JP2012065767A patent/JP2012121929A/ja not_active Withdrawn
-
2013
- 2013-03-05 HR HRP20130192TT patent/HRP20130192T1/hr unknown
- 2013-06-05 US US13/910,708 patent/US8754223B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1106227A1 (en) | Crystalline form of a biphenyl compound | |
TW200800948A (en) | Novel compound | |
WO2007127297A3 (en) | Crystalline forms of a dimethylphenyl compound | |
TW200714586A (en) | Crystalline forms of a biphenyl compound | |
BRPI0906104A2 (pt) | "derivado de ácido nuclêico peptídico, composição farmacêutica contendo uma quantidade "terapeuticamente eficaz do derivado de ácido nuclêico peptídico, composição farmacêutica contendo uma quantidade terapeuticamente eficaz do derivado de ácido nuclêico peptídico,método de utilização do derivado de ácido nuclêico peptídico e composto" | |
NO20091620L (no) | Boronsyre og estere som inhibitorer av fettsyreamidhydrolaser | |
NO20080122L (no) | Blanding av diisononylestere av 1,2syklodikarbonsyrer, fremgangsmate for dere fremstilling og anvendelse derav | |
MY174452A (en) | Substituted piperidines that increase p53 activity and the uses thereof | |
WO2007079163A3 (en) | Prokineticin 1 receptor antagonists | |
WO2008068615A8 (en) | Crystalline forms of ( 3 s ) -3- [n- (n' - (2-tert-butylphenyl) oxamyl) alaninyl] amino-5- (2 ', 3 ', 5 ', 6 ' -tetrafluoro phenoxy) -4-0x0penta noic acid | |
WO2008050199A8 (en) | Substituted phenylmethyl bicyclocarboxyamide compounds | |
EA201390481A1 (ru) | Кристаллические оксалатные соли диамидного соединения | |
PT2049480E (pt) | Derivados de 2-arilindole como inibidores da mpges-i | |
SG10201407913UA (en) | Crystalline freebase forms of a biphenyl compound | |
MX2011005090A (es) | Forma cristalina de un compuesto de 4-[2-(2-fluorofenoximetil)feni l] piperidina. | |
WO2005123679A3 (en) | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | |
EP1780207A3 (en) | Crystalline esomeprazole strontium hydrate, method for preparing the same and pharmaceutical composition containing the same | |
WO2005123670A3 (en) | Crystalline form of a substituted pyrrolidine compound | |
CY1112979T1 (el) | Διαδικασια για την παρασκευη της ενωσης (s)-1-αλκυλ-2',6'-πιπεκολοξυλιδιδιου | |
TW200609233A (en) | Racemization method | |
CY1113646T1 (el) | Κρυσταλλικη μορφη μιας ενωσης διφαινυλιου | |
SI1546083T1 (sl) | Nove substituirane arilheksadienojske kisline in njihovi estri ki se lahko uporabljajo za zdravljenje in preprečevanje diabetesa dislipidemije in ateroskleroze farmacevtski sestavki ki jih vsebujejo in postopek njihove priprave | |
TH101961B (th) | สารประกอบชนิดใหม่ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230815 |