HK1097768A1 - Modified pyrimidine glucocorticoid receptor modulators - Google Patents

Modified pyrimidine glucocorticoid receptor modulators

Info

Publication number
HK1097768A1
HK1097768A1 HK07105207.1A HK07105207A HK1097768A1 HK 1097768 A1 HK1097768 A1 HK 1097768A1 HK 07105207 A HK07105207 A HK 07105207A HK 1097768 A1 HK1097768 A1 HK 1097768A1
Authority
HK
Hong Kong
Prior art keywords
receptor modulators
glucocorticoid receptor
modified pyrimidine
pyrimidine glucocorticoid
modified
Prior art date
Application number
HK07105207.1A
Other languages
English (en)
Inventor
Robin D Clark
Nicholas C Ray
Karen Williams
Peter H Crackett
Gwen Hickin
David A Clark
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of HK1097768A1 publication Critical patent/HK1097768A1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
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  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
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HK07105207.1A 2004-07-02 2007-05-17 Modified pyrimidine glucocorticoid receptor modulators HK1097768A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58501804P 2004-07-02 2004-07-02
PCT/US2005/023675 WO2006014394A1 (en) 2004-07-02 2005-06-29 Modified pyrimidine glucocorticoid receptor modulators

Publications (1)

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HK1097768A1 true HK1097768A1 (en) 2007-07-06

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HK07105207.1A HK1097768A1 (en) 2004-07-02 2007-05-17 Modified pyrimidine glucocorticoid receptor modulators

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US (2) US7576076B2 (US07794700-20100914-C00152.png)
EP (1) EP1778236B1 (US07794700-20100914-C00152.png)
JP (1) JP4958774B2 (US07794700-20100914-C00152.png)
KR (1) KR101210730B1 (US07794700-20100914-C00152.png)
AT (1) ATE473744T1 (US07794700-20100914-C00152.png)
AU (1) AU2005270039B2 (US07794700-20100914-C00152.png)
CA (1) CA2572544C (US07794700-20100914-C00152.png)
CY (1) CY1110828T1 (US07794700-20100914-C00152.png)
DE (1) DE602005022319D1 (US07794700-20100914-C00152.png)
DK (1) DK1778236T3 (US07794700-20100914-C00152.png)
ES (1) ES2348667T3 (US07794700-20100914-C00152.png)
HK (1) HK1097768A1 (US07794700-20100914-C00152.png)
IL (1) IL180508A0 (US07794700-20100914-C00152.png)
NZ (1) NZ552984A (US07794700-20100914-C00152.png)
PT (1) PT1778236E (US07794700-20100914-C00152.png)
WO (1) WO2006014394A1 (US07794700-20100914-C00152.png)
ZA (1) ZA200700616B (US07794700-20100914-C00152.png)

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JP2008524331A (ja) * 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
ZA200802857B (en) 2005-09-14 2009-09-30 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
JPWO2008018592A1 (ja) * 2006-08-11 2010-01-07 大正製薬株式会社 プロスタグランジン誘導体含有外用剤
TWI410422B (zh) 2007-01-15 2013-10-01 Mitsubishi Tanabe Pharma Corp 縮合四氫喹啉衍生物及其醫藥用途
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EP2211845B1 (en) 2007-10-17 2017-02-22 Laboratoire HRA Pharma Glucocorticoid receptor antagonists such as mifepristone for treating cushing's syndrome
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US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
WO2016032127A2 (ko) * 2014-08-25 2016-03-03 부산대학교 산학협력단 Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도
KR101686872B1 (ko) * 2014-08-25 2016-12-20 부산대학교 산학협력단 Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity
KR20180052120A (ko) 2015-08-13 2018-05-17 코어셉트 쎄라퓨틱스, 잉크. Acth-의존성 쿠싱 증후군을 감별 진단하는 방법
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WO2019236487A1 (en) * 2018-06-04 2019-12-12 Corcept Therapeutics Incorporated Pyrimidine cyclohexenyl glucocorticoid receptor modulators
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
KR102657097B1 (ko) 2018-12-19 2024-04-15 코어셉트 쎄라퓨틱스 인코포레이티드 헤테로아릴-케톤 융합 아자데칼린 화합물인 렐라코릴란트를 함유하는 약학적 제제
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11903945B2 (en) 2019-12-11 2024-02-20 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant
CA3182272A1 (en) 2020-05-06 2021-11-11 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
CA3202353A1 (en) 2020-12-21 2022-06-30 Jeffrey Mark Dener Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators

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ZA200700616B (en) 2008-09-25
WO2006014394A1 (en) 2006-02-09
US8173664B2 (en) 2012-05-08
KR101210730B1 (ko) 2012-12-10
US20090275600A1 (en) 2009-11-05
PT1778236E (pt) 2010-10-19
JP4958774B2 (ja) 2012-06-20
KR20070039579A (ko) 2007-04-12
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AU2005270039B2 (en) 2011-09-01
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AU2005270039A1 (en) 2006-02-09
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CY1110828T1 (el) 2015-06-10

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