HK1092708A1 - Polyacetal drug conjugates as release system - Google Patents

Polyacetal drug conjugates as release system

Info

Publication number
HK1092708A1
HK1092708A1 HK06113449.4A HK06113449A HK1092708A1 HK 1092708 A1 HK1092708 A1 HK 1092708A1 HK 06113449 A HK06113449 A HK 06113449A HK 1092708 A1 HK1092708 A1 HK 1092708A1
Authority
HK
Hong Kong
Prior art keywords
linker
occurrence
succinamide
polyacetal
release system
Prior art date
Application number
HK06113449.4A
Other languages
English (en)
Inventor
Mikhail I Papisov
Alexander Yurkovetskiy
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of HK1092708A1 publication Critical patent/HK1092708A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06113449.4A 2003-09-05 2006-12-06 Polyacetal drug conjugates as release system HK1092708A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50057103P 2003-09-05 2003-09-05
PCT/US2004/029130 WO2005023294A2 (en) 2003-09-05 2004-09-04 Polyacetal drug conjugates as release system

Publications (1)

Publication Number Publication Date
HK1092708A1 true HK1092708A1 (en) 2007-02-16

Family

ID=34272970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06113449.4A HK1092708A1 (en) 2003-09-05 2006-12-06 Polyacetal drug conjugates as release system

Country Status (10)

Country Link
US (4) US7790150B2 (ja)
EP (1) EP1667726B1 (ja)
JP (3) JP5537763B2 (ja)
AT (1) ATE507845T1 (ja)
AU (1) AU2004270251B2 (ja)
CA (1) CA2537993C (ja)
DE (1) DE602004032553D1 (ja)
ES (1) ES2365918T3 (ja)
HK (1) HK1092708A1 (ja)
WO (1) WO2005023294A2 (ja)

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US8030459B2 (en) * 2002-07-19 2011-10-04 The General Hospital Corporation Oxime conjugates and methods for their formation and use
EP1667726B1 (en) * 2003-09-05 2011-05-04 The General Hospital Corporation Polyacetal drug conjugates as release system
WO2006122223A2 (en) * 2005-05-10 2006-11-16 Emory University Strategies for delivery of active agents using micelles and particles
US8252846B2 (en) * 2005-05-10 2012-08-28 Emory University Strategies for delivery of active agents using micelles and particles
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EP2146747A1 (en) * 2007-04-12 2010-01-27 Emory University Novel strategies for delivery of active agents using micelles and particles
US20080255175A1 (en) * 2007-04-16 2008-10-16 Lam Marina K Anti-cancer agents, compositions and methods of treating cancers
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AR074584A1 (es) * 2008-12-10 2011-01-26 Mersana Therapeutics Inc Formulaciones farmaceuticas de conjugados camtotecina-polimero biocompatibles biodegradables
WO2010074958A1 (en) * 2008-12-22 2010-07-01 The Trustees Of The University Of Pennsylvania Hydrolytically degradable polysaccharide hydrogels
US8524214B2 (en) * 2009-05-28 2013-09-03 Mersana Therapeutics, Inc. Polyal drug conjugates comprising variable rate-releasing linkers
WO2010144881A1 (en) * 2009-06-12 2010-12-16 The General Hospital Corporation Treatment of meningeal and neural diseases
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US9486404B2 (en) 2011-03-28 2016-11-08 The Trustees Of The University Of Pennsylvania Infarction treatment compositions and methods
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US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
US20140017265A1 (en) * 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
AU2013359506B2 (en) * 2012-12-10 2018-05-24 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
EP2931316B1 (en) * 2012-12-12 2019-02-20 Mersana Therapeutics, Inc. Hydroxyl-polymer-drug-protein conjugates
WO2014160360A1 (en) * 2013-03-14 2014-10-02 Mersana Therapeutics Inc. Tubulysin compounds and conjugates thereof
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TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗ｈｅｒ２表位之單株抗體及其使用之方法
US11324827B2 (en) 2014-10-01 2022-05-10 Xiamen Sinopeg Biotech Co., Ltd. Multifunctionalized polyethylene glycol derivative and preparation method therefor
CN104877127B (zh) 2015-06-23 2017-11-10 厦门赛诺邦格生物科技股份有限公司 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质
US11433136B2 (en) * 2015-12-18 2022-09-06 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
CN109310885B (zh) 2016-03-15 2022-05-31 梅尔莎纳医疗公司 NaPi2b靶向抗体-药物缀合物及其使用方法
AU2017273871B2 (en) * 2016-06-03 2020-03-26 Novacyte Therapeutics Company.,LTD Polymer linkers and their uses
TW201834697A (zh) 2017-02-28 2018-10-01 美商梅爾莎納醫療公司 Her2標靶抗體－藥物結合物之組合療法
KR101875321B1 (ko) 2017-03-15 2018-07-05 인하대학교 산학협력단 트리펩타이드 및 다이펩타이드 유도체, 이의 제조방법, 이를 포함하는 화학센서 및 이를 이용한 알루미늄 이온 및 3가 금속이온을 비례 형광형으로 검출하는 방법
AU2018290330A1 (en) 2017-06-22 2020-01-02 Mersana Therapeutics, Inc. Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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Also Published As

Publication number Publication date
ES2365918T3 (es) 2011-10-13
US20070190018A1 (en) 2007-08-16
US7790150B2 (en) 2010-09-07
US20110059010A1 (en) 2011-03-10
ATE507845T1 (de) 2011-05-15
CA2537993A1 (en) 2005-03-17
JP5537763B2 (ja) 2014-07-02
CA2537993C (en) 2012-08-28
JP2011153159A (ja) 2011-08-11
US8546419B2 (en) 2013-10-01
US8247427B2 (en) 2012-08-21
JP2014111657A (ja) 2014-06-19
EP1667726B1 (en) 2011-05-04
EP1667726A2 (en) 2006-06-14
WO2005023294A3 (en) 2005-06-09
AU2004270251A1 (en) 2005-03-17
US8101164B2 (en) 2012-01-24
US20120289535A1 (en) 2012-11-15
US20120004255A1 (en) 2012-01-05
WO2005023294A2 (en) 2005-03-17
DE602004032553D1 (de) 2011-06-16
JP2007504253A (ja) 2007-03-01
AU2004270251B2 (en) 2011-03-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180901