HK1091818A1 - 具有血管生成抑制活性的取代的吡啶和哒嗪 - Google Patents

具有血管生成抑制活性的取代的吡啶和哒嗪 Download PDF

Info

Publication number
HK1091818A1
HK1091818A1 HK06112289.9A HK06112289A HK1091818A1 HK 1091818 A1 HK1091818 A1 HK 1091818A1 HK 06112289 A HK06112289 A HK 06112289A HK 1091818 A1 HK1091818 A1 HK 1091818A1
Authority
HK
Hong Kong
Prior art keywords
group
ring
substituted
alkyl
amino
Prior art date
Application number
HK06112289.9A
Other languages
English (en)
Chinese (zh)
Other versions
HK1091818B (en
Inventor
P. Dumas Jacques
Kite Joe Teddy
C.E. Kluender Harold
Lee Wendy
Nagarathnam Dhanapalan
N. Sibley Robert
Su Ning
James Boyer Stephen
A. Dixon Julie
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HK1091818A1 publication Critical patent/HK1091818A1/xx
Publication of HK1091818B publication Critical patent/HK1091818B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
HK06112289.9A 1999-09-28 2006-11-08 Substitued pyridines and pyridazines with angiogenesis inhibiting activity HK1091818B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28
US09/407600 1999-09-28

Publications (2)

Publication Number Publication Date
HK1091818A1 true HK1091818A1 (zh) 2007-01-26
HK1091818B HK1091818B (en) 2009-07-31

Family

ID=

Also Published As

Publication number Publication date
EE05258B1 (et) 2010-02-15
CN1420879A (zh) 2003-05-28
EE200200161A (et) 2003-08-15
WO2001023375A2 (en) 2001-04-05
ATE422494T1 (de) 2009-02-15
HRP20020308B1 (cs) 2013-01-31
PE20010607A1 (es) 2001-07-12
GT200000158A (es) 2002-03-16
IL193368A (en) 2011-05-31
SK5912002A3 (en) 2003-01-09
HK1091819A1 (zh) 2007-01-26
CN1769283A (zh) 2006-05-10
TW593315B (en) 2004-06-21
DOP2000000070A (es) 2002-02-28
IL148880A0 (en) 2002-09-12
CZ304767B6 (cs) 2014-10-08
CA2385817C (en) 2010-05-04
CO5200835A1 (es) 2002-09-27
MY135058A (en) 2008-01-31
UA75053C2 (en) 2006-03-15
CN100374435C (zh) 2008-03-12
DE60041548D1 (de) 2009-03-26
HUP0202704A2 (hu) 2002-12-28
YU22902A (sh) 2004-12-31
CZ20021444A3 (cs) 2002-08-14
RS50369B (sr) 2009-11-10
BG65860B1 (bg) 2010-03-31
CN100422173C (zh) 2008-10-01
IL193367A0 (en) 2009-02-11
MY143580A (en) 2011-05-31
CN1769282A (zh) 2006-05-10
EP1228063A2 (en) 2002-08-07
BR0014382A (pt) 2003-06-24
AU1569601A (en) 2001-04-30
JP4919567B2 (ja) 2012-04-18
PL205957B1 (pl) 2010-06-30
ES2320525T3 (es) 2009-05-25
AR025752A1 (es) 2002-12-11
NZ518589A (en) 2005-03-24
HRP20020308A2 (en) 2004-06-30
KR100895572B1 (ko) 2009-04-29
MXPA02003156A (es) 2002-09-30
RU2260008C2 (ru) 2005-09-10
BR0014382B1 (pt) 2014-04-01
MY143377A (en) 2011-05-13
BRPI0014382B8 (pt) 2021-05-25
CN100422172C (zh) 2008-10-01
KR100895571B1 (ko) 2009-04-29
BG106637A (bg) 2003-02-28
ZA200202760B (en) 2003-10-29
IL193367A (en) 2011-03-31
WO2001023375A3 (en) 2002-05-02
KR100890473B1 (ko) 2009-03-26
NO20021520L (no) 2002-05-23
AR082231A2 (es) 2012-11-21
NO20021520D0 (no) 2002-03-26
HUP0202704A3 (en) 2003-12-29
JP2003526632A (ja) 2003-09-09
SK287417B6 (sk) 2010-09-07
KR20080091505A (ko) 2008-10-13
AR082232A2 (es) 2012-11-21
PL366342A1 (en) 2005-01-24
AU782820B2 (en) 2005-09-01
KR20020038775A (ko) 2002-05-23
EP1228063B1 (en) 2009-02-11
HU230223B1 (en) 2015-10-28
IL193368A0 (en) 2009-02-11
KR20080086547A (ko) 2008-09-25
PA8503201A1 (es) 2002-08-26
MA25563A1 (fr) 2002-10-01
CA2385817A1 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
CN100422172C (zh) 具有血管生成抑制活性的取代的吡啶和哒嗪
KR20030040419A (ko) 단백질 키나아제 억제제인 융합된 피라졸 유도체
KR20080059112A (ko) Vegf 수용체 및 hgf 수용체 신호전달의 억제제
WO2005007632A1 (en) Substituted pyridazinones as inhibitors of p38
US6689883B1 (en) Substituted pyridines and pyridazines with angiogenesis inhibiting activity
JP2003506447A (ja) 血管形成阻害活性をもつ置換ピリダジン類および縮合ピリダジン類
US20110263597A1 (en) Substituted pyridines and pyridazines with angiogenesis inhibiting activity
CN111356695B (zh) 新的三环化合物
HK1091818B (en) Substitued pyridines and pyridazines with angiogenesis inhibiting activity
HK1091819B (en) Substitued pyridines and pyridazines with angiogenesis inhibiting activity

Legal Events

Date Code Title Description
PE Patent expired