HK1090915A1 - Processes and intermediates for preparing 2-substituted piperidine stereoisomers - Google Patents

Processes and intermediates for preparing 2-substituted piperidine stereoisomers

Info

Publication number
HK1090915A1
HK1090915A1 HK06107491.3A HK06107491A HK1090915A1 HK 1090915 A1 HK1090915 A1 HK 1090915A1 HK 06107491 A HK06107491 A HK 06107491A HK 1090915 A1 HK1090915 A1 HK 1090915A1
Authority
HK
Hong Kong
Prior art keywords
erythro
stereoisomers
carbon atoms
threo
reacting
Prior art date
Application number
HK06107491.3A
Other languages
English (en)
Inventor
Sowmianarayanan Ramaswamy
Vickram Khetani
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HK1090915A1 publication Critical patent/HK1090915A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06107491.3A 1997-01-31 2006-07-03 Processes and intermediates for preparing 2-substituted piperidine stereoisomers HK1090915A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/792,661 US5965734A (en) 1997-01-31 1997-01-31 Processes and intermediates for preparing 2-substituted piperidine stereoisomers
EP98923727A EP1082307B1 (fr) 1997-01-31 1998-05-26 Procedes et produits intermediaires servant a la preparation de stereo-isomeres de piperidine 2-substituee
PCT/US1998/010599 WO1999061425A1 (fr) 1997-01-31 1998-05-26 Procedes et produits intermediaires servant a la preparation de stereo-isomeres de piperidine 2-substituee
EP05077084A EP1612207B1 (fr) 1997-01-31 1998-05-26 Procédés et produits intermediaires pour la préparation de stereo-isomeres de piperidine 2-substituee

Publications (1)

Publication Number Publication Date
HK1090915A1 true HK1090915A1 (en) 2007-01-05

Family

ID=26794135

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06107491.3A HK1090915A1 (en) 1997-01-31 2006-07-03 Processes and intermediates for preparing 2-substituted piperidine stereoisomers

Country Status (13)

Country Link
US (1) US5965734A (fr)
EP (2) EP1612207B1 (fr)
JP (1) JP4491135B2 (fr)
AT (2) ATE304531T1 (fr)
AU (1) AU765194B2 (fr)
CA (1) CA2333089C (fr)
CY (1) CY1108818T1 (fr)
DE (2) DE69840457D1 (fr)
DK (2) DK1082307T3 (fr)
ES (2) ES2320012T3 (fr)
HK (1) HK1090915A1 (fr)
PT (1) PT1612207E (fr)
WO (1) WO1999061425A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6359139B1 (en) * 2000-11-07 2002-03-19 Celgene Corporation Methods for production of piperidyl acetamide stereoisomers
US20020187192A1 (en) * 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
WO2003016274A2 (fr) * 2001-08-21 2003-02-27 Sepracor, Inc. Piperidines 2-substitue, ligands pour des recepteurs et des transporteurs de monoamines
US6638533B2 (en) 2002-01-03 2003-10-28 George Krsek Pulse dosage formulations of methylphenidate and method to prepare same
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US20060127421A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment using D-threo methylphenidate
ITMI20042415A1 (it) * 2004-12-17 2005-03-17 Clariant Lsm Italia Spa Sintesi di alfa-aril-alfa-piperid-2-il-acetammidi e loro idrolisi acida
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5075315A (en) * 1990-05-17 1991-12-24 Mcneilab, Inc. Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
JPH07504908A (ja) * 1992-03-16 1995-06-01 メルク　シヤープ　エンド　ドーム　リミテツド ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用
WO1995014671A1 (fr) * 1993-11-22 1995-06-01 Merck & Co., Inc. 3-acylaminobenzazepines
DE69606680T2 (de) * 1995-10-30 2000-08-17 F. Hoffmann-La Roche Ag, Basel 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
WO1999061425A1 (fr) 1999-12-02
PT1612207E (pt) 2009-02-04
ATE420073T1 (de) 2009-01-15
CA2333089A1 (fr) 1999-12-02
CA2333089C (fr) 2008-10-14
DK1612207T3 (da) 2009-05-04
EP1082307A1 (fr) 2001-03-14
JP4491135B2 (ja) 2010-06-30
AU765194B2 (en) 2003-09-11
ES2249830T3 (es) 2006-04-01
US5965734A (en) 1999-10-12
ATE304531T1 (de) 2005-09-15
EP1612207B1 (fr) 2009-01-07
ES2320012T3 (es) 2009-05-18
EP1082307B1 (fr) 2005-09-14
JP2002516313A (ja) 2002-06-04
EP1082307A4 (fr) 2004-04-14
DE69831611D1 (de) 2005-10-20
DE69831611T2 (de) 2006-06-14
EP1612207A1 (fr) 2006-01-04
CY1108818T1 (el) 2014-04-09
DK1082307T3 (da) 2005-12-19
DE69840457D1 (de) 2009-02-26
AU7595098A (en) 1999-12-13

Similar Documents

Publication Publication Date Title
HK1090915A1 (en) Processes and intermediates for preparing 2-substituted piperidine stereoisomers
DE69706366D1 (de) Verfahren zur Herstellung von Paroxetine
EP1506961A3 (fr) Procédés et intermédiaires pour résoudre des stéréoisomères de piperidyl acétamide
IL119130A0 (en) Production of optically active 2-halo-1- (substituted phenyl) ethanol and substituted styrene oxide
KR840001581A (ko) 베타-락타마제 억제제 2-베타-치환-2-알파-메틸-(5r)펜임-3-알파카복실산 1,1-디옥사이드 및 그 중간체의 제조방법
ATE334972T1 (de) Verfahren für die herstellung von 4(5)-amino-5(4)-carboxamidoimidazolen und deren zwischenprodukte
ATE189453T1 (de) Verfahren zur herstellung von 2-cyanobiphenyl- verbindungen
ATE520679T1 (de) Verfahren zur herstellung von (dioxolenon-4- yl)methylester-derivate
KR860004004A (ko) 4-아실옥시-3-옥소- 부티르산 에스테르의 제조방법
ES2002013A6 (es) Un procedimiento para preparar un acido azetidin-3-carboxilico
ATE131483T1 (de) Verfahren zur herstellung von penemen
KR920007984A (ko) 지방족 아미드 및 그의 염의 제조방법
ATE234806T1 (de) Verfahren zur herstellung von 2-alkyliden-4- bromacetessigsäureestern
EP1219610A4 (fr) Procede de preparation de derives de l'oxazole
ATE359990T1 (de) Verfahren zur herstellung von 3,5- bisalkylphenolen
KR970010769A (ko) 카바페넴 유도체의 제조방법
DE3675761D1 (de) Verfahren zur herstellung von alpha-hydroxycarbonsaeureamiden.
ATE167474T1 (de) Verfahren zur herstellung von n-alkylpyrazolen
ATE89539T1 (de) Verfahren zur herstellung von konjugierten dienen.
EP0627419A4 (fr) Derive de 1-phenylpyrrolidone a activite optique, intermediaire permettant de le produire, et leurs procedes de production.
MY107249A (en) New process for producing a phenyl propionic derivative.
TH15418A (th) ขบวนการผลิตใหม่

Legal Events

Date Code Title Description
CHRG Changes in the register

Free format text: CORRECTION OF THE NAME OF THE INVENTOR FROM KHETANI, VICKRAM TO KHETANI, VIKRAM

PE Patent expired

Effective date: 20180525