HK108997A - 1'-amino-2-(benzothiazolyl)methyl¾spiro isoquinoline-4(1H),3'-pyrrolidine¾-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors - Google Patents

1'-amino-2-(benzothiazolyl)methyl¾spiro isoquinoline-4(1H),3'-pyrrolidine¾-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Info

Publication number
HK108997A
HK108997A HK108997A HK108997A HK108997A HK 108997 A HK108997 A HK 108997A HK 108997 A HK108997 A HK 108997A HK 108997 A HK108997 A HK 108997A HK 108997 A HK108997 A HK 108997A
Authority
HK
Hong Kong
Prior art keywords
carbon atoms
aryl
lower alkyl
compounds
alkyl
Prior art date
Application number
HK108997A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/797,567 external-priority patent/US5189167A/en
Priority claimed from US07/798,294 external-priority patent/US5189168A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of HK108997A publication Critical patent/HK108997A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK108997A 1991-11-25 1997-06-26 1'-amino-2-(benzothiazolyl)methyl¾spiro isoquinoline-4(1H),3'-pyrrolidine¾-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors HK108997A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/797,567 US5189167A (en) 1991-11-25 1991-11-25 Alkylidene analogs of 1'-amino-2-[(benzothiazolyl)-methyl]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US07/798,294 US5189168A (en) 1991-11-25 1991-11-25 1'-amino-2[(benzothiazolyl)methyl]spiro-[isoquinoline-4(1H),3'-pyrrolidine]-1,2'3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
PCT/US1992/010268 WO1993011126A1 (en) 1991-11-25 1992-11-25 1'-amino-2-[(benzothiazolyl)methyl]spiro [isoquinoline-4(1h),3'-pyrrolidine]-1,2',3,5'(2h)-tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
HK108997A true HK108997A (en) 1997-08-22

Family

ID=27121893

Family Applications (1)

Application Number Title Priority Date Filing Date
HK108997A HK108997A (en) 1991-11-25 1997-06-26 1'-amino-2-(benzothiazolyl)methyl¾spiro isoquinoline-4(1H),3'-pyrrolidine¾-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Country Status (14)

Country Link
EP (1) EP0618917B1 (ja)
JP (1) JPH07501342A (ja)
AT (1) ATE150753T1 (ja)
AU (1) AU665796B2 (ja)
CA (1) CA2122916A1 (ja)
DE (1) DE69218626T2 (ja)
DK (1) DK0618917T3 (ja)
ES (1) ES2101291T3 (ja)
FI (1) FI942401A0 (ja)
GR (1) GR3023563T3 (ja)
HK (1) HK108997A (ja)
HU (1) HUT67539A (ja)
SG (1) SG47554A1 (ja)
WO (1) WO1993011126A1 (ja)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors

Also Published As

Publication number Publication date
HUT67539A (en) 1995-04-28
AU665796B2 (en) 1996-01-18
DE69218626T2 (de) 1997-07-03
FI942401A (fi) 1994-05-24
ATE150753T1 (de) 1997-04-15
JPH07501342A (ja) 1995-02-09
SG47554A1 (en) 1998-04-17
GR3023563T3 (en) 1997-08-29
EP0618917A1 (en) 1994-10-12
DE69218626D1 (de) 1997-04-30
WO1993011126A1 (en) 1993-06-10
CA2122916A1 (en) 1993-06-10
HU9401410D0 (en) 1994-08-29
AU3228493A (en) 1993-06-28
ES2101291T3 (es) 1997-07-01
FI942401A0 (fi) 1994-05-24
EP0618917B1 (en) 1997-03-26
DK0618917T3 (da) 1997-10-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)