HK1089188A1 - Novel method of synthesising perindopril and the pharmaceutically- acceptable salts thereof - Google Patents

Novel method of synthesising perindopril and the pharmaceutically- acceptable salts thereof

Info

Publication number
HK1089188A1
HK1089188A1 HK06109654.2A HK06109654A HK1089188A1 HK 1089188 A1 HK1089188 A1 HK 1089188A1 HK 06109654 A HK06109654 A HK 06109654A HK 1089188 A1 HK1089188 A1 HK 1089188A1
Authority
HK
Hong Kong
Prior art keywords
perindopril
synthesising
pharmaceutically
acceptable salts
novel method
Prior art date
Application number
HK06109654.2A
Other languages
English (en)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1089188A1 publication Critical patent/HK1089188A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06109654.2A 2003-06-30 2006-08-30 Novel method of synthesising perindopril and the pharmaceutically- acceptable salts thereof HK1089188A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03291601A EP1367061B1 (fr) 2003-06-30 2003-06-30 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/001637 WO2005003153A1 (fr) 2003-06-30 2004-06-28 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
HK1089188A1 true HK1089188A1 (en) 2006-11-24

Family

ID=29414888

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109654.2A HK1089188A1 (en) 2003-06-30 2006-08-30 Novel method of synthesising perindopril and the pharmaceutically- acceptable salts thereof

Country Status (18)

Country Link
US (1) US7179833B2 (es)
EP (1) EP1367061B1 (es)
JP (1) JP4347341B2 (es)
CN (1) CN1802384B (es)
AR (1) AR044944A1 (es)
AT (1) ATE315043T1 (es)
AU (1) AU2004253721B2 (es)
DE (1) DE60303101T2 (es)
DK (1) DK1367061T3 (es)
EA (1) EA008836B1 (es)
ES (1) ES2256689T3 (es)
HK (1) HK1089188A1 (es)
MY (1) MY139159A (es)
NZ (1) NZ544003A (es)
PL (1) PL211161B1 (es)
SI (1) SI1367061T1 (es)
WO (1) WO2005003153A1 (es)
ZA (1) ZA200510330B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1362864B1 (fr) * 2003-06-30 2007-04-25 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
ATE310012T1 (de) * 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US7615571B2 (en) * 2004-05-31 2009-11-10 Ipca Laboratories Ltd. Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt
EP2837393A1 (en) * 2004-10-20 2015-02-18 Ethicon, Inc. Absorbable hemostat
US9358318B2 (en) * 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
ES2314583T4 (es) 2005-01-06 2009-05-18 Ipca Laboratories Limited Proceso para sintesis de los derivados del acido (2s,3as,7as)-1-(s)-alanil-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindropil.
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
SI9500140A (en) * 1995-04-24 1996-10-31 Genesis Para La Investigacion Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril

Also Published As

Publication number Publication date
US20060178421A1 (en) 2006-08-10
US7179833B2 (en) 2007-02-20
NZ544003A (en) 2009-03-31
PL211161B1 (pl) 2012-04-30
DK1367061T3 (da) 2006-05-15
DE60303101D1 (de) 2006-03-30
PL380408A1 (pl) 2007-01-22
EP1367061A1 (fr) 2003-12-03
AU2004253721B2 (en) 2007-12-20
ES2256689T3 (es) 2006-07-16
MY139159A (en) 2009-08-28
AR044944A1 (es) 2005-10-12
EA008836B1 (ru) 2007-08-31
CN1802384A (zh) 2006-07-12
ATE315043T1 (de) 2006-02-15
JP2007537974A (ja) 2007-12-27
CN1802384B (zh) 2010-06-16
DE60303101T2 (de) 2006-09-28
ZA200510330B (en) 2007-05-30
EP1367061B1 (fr) 2006-01-04
EA200501925A1 (ru) 2006-06-30
JP4347341B2 (ja) 2009-10-21
WO2005003153A1 (fr) 2005-01-13
SI1367061T1 (sl) 2006-04-30
AU2004253721A1 (en) 2005-01-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180628