HK1089175A1 - Azaindole-derivatives as factor xa inhibitors - Google Patents

Azaindole-derivatives as factor xa inhibitors

Info

Publication number
HK1089175A1
HK1089175A1 HK06109646A HK06109646A HK1089175A1 HK 1089175 A1 HK1089175 A1 HK 1089175A1 HK 06109646 A HK06109646 A HK 06109646A HK 06109646 A HK06109646 A HK 06109646A HK 1089175 A1 HK1089175 A1 HK 1089175A1
Authority
HK
Hong Kong
Prior art keywords
azaindole
inhibitors
derivatives
factor
Prior art date
Application number
HK06109646A
Other languages
English (en)
Inventor
Nazare Marc
Wehner Volkmar
Will David William
Ritter Kurt
Urmann Matthias
Matter Hans
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1089175A1 publication Critical patent/HK1089175A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06109646A 2003-05-19 2006-08-30 Azaindole-derivatives as factor xa inhibitors HK1089175A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03011304A EP1479680A1 (fr) 2003-05-19 2003-05-19 Derivés d' azaindole en tant qu'inhibiteurs du facteur Xa
PCT/EP2004/004754 WO2004101563A1 (fr) 2003-05-19 2004-05-05 Derives azaindole servant d'inhibiteurs du facteur xa

Publications (1)

Publication Number Publication Date
HK1089175A1 true HK1089175A1 (en) 2006-11-24

Family

ID=33040951

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109646A HK1089175A1 (en) 2003-05-19 2006-08-30 Azaindole-derivatives as factor xa inhibitors

Country Status (25)

Country Link
EP (2) EP1479680A1 (fr)
JP (1) JP4733642B2 (fr)
KR (1) KR20060012636A (fr)
CN (1) CN100347172C (fr)
AR (1) AR045682A1 (fr)
AU (1) AU2004238500B2 (fr)
BR (1) BRPI0410429A (fr)
CA (1) CA2526084A1 (fr)
CL (1) CL2004001079A1 (fr)
CR (1) CR8088A (fr)
EC (1) ECSP056179A (fr)
HK (1) HK1089175A1 (fr)
MA (1) MA27799A1 (fr)
MX (1) MXPA05012156A (fr)
NO (1) NO20055911L (fr)
NZ (1) NZ543669A (fr)
OA (1) OA13169A (fr)
PE (1) PE20050554A1 (fr)
RS (1) RS20050857A (fr)
RU (1) RU2330853C2 (fr)
TN (1) TNSN05296A1 (fr)
TW (1) TW200510411A (fr)
UA (1) UA86767C2 (fr)
WO (1) WO2004101563A1 (fr)
ZA (1) ZA200508150B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515926A (ja) * 2005-11-18 2009-04-16 エフ．ホフマン−ラ ロシュ アーゲー アザインドール−２−カルボキサミド誘導体
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
EP2885301A1 (fr) 2012-08-17 2015-06-24 Bayer CropScience AG Amides d'acide azaindole-carboxylique et thiocarboxylique comme insecticides et acaricides
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
CN111834531B (zh) * 2019-04-15 2022-04-19 天津大学 一种有机半导体材料、制备方法及应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241472B (it) 1990-07-06 1994-01-17 Olivier Linda Dispositivo elettromeccanico per la cattura continua in particolare di topi e ratti.
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
EP1384725A3 (fr) 1994-04-26 2007-02-21 Aventis Pharmaceuticals Inc. Inhibiteurs de facteur Xa
CA2315070A1 (fr) * 1997-12-17 1999-07-01 Schering Aktiengesellschaft Derives d'(ortho)-anthranilamide comme anticoagulants
RU2225397C2 (ru) * 1997-12-24 2004-03-10 Авентис Фарма Дойчланд Гмбх Производные индола как ингибиторы фактора Ха
EP0987274A1 (fr) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Inhibiteurs du facteur VIIa
JP4241970B2 (ja) * 1998-10-30 2009-03-18 中外製薬株式会社 アミド結合を有するインドール誘導体、及びモノ又はジアザインドール誘導体
CZ2002961A3 (cs) * 1999-09-17 2002-08-14 Millennium Pharmaceuticals, Inc. Benzamidy a příbuzné sloučeniny pro inhibici faktoru Xa
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
JP2001294572A (ja) * 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
US6436965B1 (en) * 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
WO2002000651A2 (fr) * 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Inhibiteurs du facteur xa
EP1368354A1 (fr) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulateurs de l'activite du recepteur de la chimiokine
US6790845B2 (en) * 2001-04-09 2004-09-14 Bristol-Myers Squibb Pharma Company Fused heterocyclic inhibitors of factor Xa
EP1314733A1 (fr) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides comme inhibiteurs du facteur Xa
AU2002366801B8 (en) * 2001-12-20 2009-05-21 Osi Pharmaceuticals, Inc. Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
DE10214832A1 (de) * 2002-04-04 2003-10-16 Merck Patent Gmbh Phenylderivate 4
JP2004203791A (ja) * 2002-12-25 2004-07-22 Dai Ichi Seiyaku Co Ltd 芳香族化合物
JP2004210716A (ja) * 2002-12-27 2004-07-29 Dai Ichi Seiyaku Co Ltd ジアミド誘導体
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors

Also Published As

Publication number Publication date
OA13169A (en) 2006-12-13
CA2526084A1 (fr) 2004-11-25
JP4733642B2 (ja) 2011-07-27
KR20060012636A (ko) 2006-02-08
ZA200508150B (en) 2007-02-28
TW200510411A (en) 2005-03-16
CN100347172C (zh) 2007-11-07
RS20050857A (en) 2007-11-15
MXPA05012156A (es) 2006-08-18
ECSP056179A (es) 2006-08-30
EP1636226A1 (fr) 2006-03-22
UA86767C2 (ru) 2009-05-25
PE20050554A1 (es) 2005-08-04
EP1479680A1 (fr) 2004-11-24
NO20055911L (no) 2006-02-10
BRPI0410429A (pt) 2006-06-06
MA27799A1 (fr) 2006-03-01
WO2004101563A1 (fr) 2004-11-25
EP1636226B1 (fr) 2014-10-15
CN1791601A (zh) 2006-06-21
CL2004001079A1 (es) 2005-04-08
AU2004238500B2 (en) 2010-07-22
RU2005139557A (ru) 2007-06-27
RU2330853C2 (ru) 2008-08-10
JP2006528214A (ja) 2006-12-14
CR8088A (es) 2006-09-22
AU2004238500A1 (en) 2004-11-25
TNSN05296A1 (en) 2007-07-10
NZ543669A (en) 2008-12-24
AR045682A1 (es) 2005-11-09

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110505