HK1087031A1 - Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof - Google Patents

Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof

Info

Publication number
HK1087031A1
HK1087031A1 HK06107316A HK06107316A HK1087031A1 HK 1087031 A1 HK1087031 A1 HK 1087031A1 HK 06107316 A HK06107316 A HK 06107316A HK 06107316 A HK06107316 A HK 06107316A HK 1087031 A1 HK1087031 A1 HK 1087031A1
Authority
HK
Hong Kong
Prior art keywords
active principle
release
subsequent
linearlyvarying
subcutaneous implants
Prior art date
Application number
HK06107316A
Other languages
English (en)
Inventor
Patrice Mauriac
Pierre Marion
Original Assignee
Mediolanum Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT001301A external-priority patent/ITMI20031301A1/it
Priority claimed from IT001299A external-priority patent/ITMI20031299A1/it
Priority claimed from IT001300A external-priority patent/ITMI20031300A1/it
Priority claimed from IT001303A external-priority patent/ITMI20031303A1/it
Application filed by Mediolanum Pharmaceuticals Ltd filed Critical Mediolanum Pharmaceuticals Ltd
Publication of HK1087031A1 publication Critical patent/HK1087031A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
HK06107316A 2003-06-26 2006-06-28 Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof HK1087031A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT001301A ITMI20031301A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei contenenti un principio attivo in grado di aumentare la densita' ossea in associazione con acido polilattico-glicolico per il trattamento dell'osteoporosi.
IT001299A ITMI20031299A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei aventi un rilascio iniziale limitato del principio attivo ed un successivo rilascio del medesimo in maniera estesa con andamento lineare.
IT001300A ITMI20031300A1 (it) 2003-06-26 2003-06-26 Impianti sottocutanei contenenti principi attivi ad attivita' analgesica narcotica.
IT001303A ITMI20031303A1 (it) 2003-06-26 2003-06-26 Composizioni per impianti sottocutanei contenenti almeno un ormone steroideo per la terapia ormonale sostitutiva e per la contraccezione.
PCT/EP2004/051230 WO2005000278A1 (en) 2003-06-26 2004-06-24 Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof

Publications (1)

Publication Number Publication Date
HK1087031A1 true HK1087031A1 (en) 2006-10-06

Family

ID=33556509

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06107316A HK1087031A1 (en) 2003-06-26 2006-06-28 Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof

Country Status (17)

Country Link
US (1) US20070116738A1 (xx)
EP (1) EP1638535B1 (xx)
JP (1) JP2009513493A (xx)
KR (1) KR20060027353A (xx)
CN (1) CN100592904C (xx)
AT (1) ATE367803T1 (xx)
AU (1) AU2004251457B2 (xx)
BR (1) BRPI0411752A (xx)
CA (1) CA2530120A1 (xx)
CY (1) CY1106943T1 (xx)
DE (1) DE602004007802T2 (xx)
ES (1) ES2291893T3 (xx)
HK (1) HK1087031A1 (xx)
MX (1) MXPA05013698A (xx)
PL (1) PL1638535T3 (xx)
PT (1) PT1638535E (xx)
WO (1) WO2005000278A1 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2575988C (en) 2004-08-04 2014-02-18 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US8946277B2 (en) * 2008-04-18 2015-02-03 Warsaw Orthopedic, Inc. Clonidine formulations in a biodegradable polymer carrier
US9132085B2 (en) * 2008-04-18 2015-09-15 Warsaw Orthopedic, Inc. Compositions and methods for treating post-operative pain using clonidine and bupivacaine
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
US9289409B2 (en) * 2008-04-18 2016-03-22 Warsaw Orthopedic, Inc. Sulindac formulations in a biodegradable material
US9125917B2 (en) * 2008-04-18 2015-09-08 Warsaw Orthopedic, Inc. Fluocinolone formulations in a biodegradable polymer carrier
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US9610243B2 (en) 2008-04-18 2017-04-04 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
WO2011037953A2 (en) * 2009-09-22 2011-03-31 Surmodics Pharmaceuticals, Inc. Implant devices having varying bioactive agent loading configurations
US20110086083A1 (en) * 2009-09-22 2011-04-14 Danielle Biggs Implant devices for modulating bioactive agent release profiles
JP6134788B2 (ja) * 2012-06-27 2017-05-24 メドインセルル 疎水性組成物のための生分解性薬物送達
US20160022570A1 (en) 2014-07-25 2016-01-28 Robert W. Adams Medical implant
CN214181164U (zh) * 2020-04-23 2021-09-14 克林维尔制药有限公司 药物植入物装置及多部分套件

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
JP3720386B2 (ja) * 1993-12-27 2005-11-24 住友製薬株式会社 薬物放出制御製剤
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
US6406745B1 (en) * 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
ATE463342T1 (de) * 1999-07-16 2010-04-15 Univ Wm Marsh Rice Temperaturabhängiges polymer/nanohüllen-komposite für photothermische modulierte arzneimittelabgabe
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
WO2003051328A1 (en) * 2001-12-18 2003-06-26 Novo Nordisk A/S Solid dose micro implant
EP1503731A1 (en) * 2002-05-07 2005-02-09 Control Delivery Systems, Inc. Processes for forming a drug delivery device
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
AU2004207523A1 (en) * 2003-01-24 2004-08-12 Control Delivery Systems, Inc. Controlled release of highly soluble agents

Also Published As

Publication number Publication date
AU2004251457B2 (en) 2010-09-23
CN100592904C (zh) 2010-03-03
CA2530120A1 (en) 2005-01-06
EP1638535B1 (en) 2007-07-25
AU2004251457A1 (en) 2005-01-06
DE602004007802T2 (de) 2008-04-17
ATE367803T1 (de) 2007-08-15
KR20060027353A (ko) 2006-03-27
CN1812771A (zh) 2006-08-02
US20070116738A1 (en) 2007-05-24
CY1106943T1 (el) 2012-09-26
JP2009513493A (ja) 2009-04-02
PT1638535E (pt) 2007-11-08
BRPI0411752A (pt) 2006-08-08
PL1638535T3 (pl) 2007-12-31
ES2291893T3 (es) 2008-03-01
MXPA05013698A (es) 2006-05-17
EP1638535A1 (en) 2006-03-29
WO2005000278A1 (en) 2005-01-06
DE602004007802D1 (de) 2007-09-06

Similar Documents

Publication Publication Date Title
HK1087031A1 (en) Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof
WO2005044224A3 (en) Drug delivery system based on polymer nanoshells
WO2003028660A3 (en) Drug delivery devices and methods
WO2004000389A3 (en) Rapidly dissolving micro-perforator for drug delivery and other applications
MY162248A (en) Hydrophilic coating
WO2005115493A3 (en) Thermal treatment of an implantable medical device
WO2007041584A3 (en) Implantable sensors, implantable pumps, and anti-scarring drug combinations
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
UA95993C2 (ru) Композиция пеллеты пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, способ ее изготовления и ее применение
DE60118395D1 (de) Pharmazeutische zusammensetzungen mit verzögerter freisetzung für die parenterale applikation von hydrophilen wirkstoffen
ATE498027T1 (de) Wirkstoffabgebende verbundkörper
WO2007041463A3 (en) Electrical devices and anti-scarring drug combinations
WO2008109462A3 (en) Sustained release pellets comprising wax-like material
CL2003002277A1 (es) Composicion farmaceutica inyectable, de deposito de liberacion prolongada, que comprende un agente beneficioso disuelto o disperso en un gel constituido por un polimero bioerosionable y biocompatible; y un solvente.
WO2004035020A3 (en) Controlled release preparation
ATE412437T1 (de) Silber enthaltende zusammensetzungen, geräte und verfahren zu deren herstellung
WO2001060335A3 (en) Delivery systems using preformed biodegradable polymer compositions and methods
DE60232147D1 (de) Pharmazeutische zubereitung mit verzögerter wirkstoff-freisetzung enthaltend milchsäure-glycolsäure copolymer, und verfahren zu deren herstellung
ATE344022T1 (de) Proinsulin c-peptid enthaltende arzneizubereitung mit verzögerter wirkstofffreigabe
WO2006121522A3 (en) Implantable sensors and pumps, anti-scarring agents, and therapeutic compositions
ATE258044T1 (de) Verfahren zur herstellung einer mit bändern versehenen dosisform zur verlängerten freisetzung eines wirkstoffs
WO2006069344A3 (en) Controlled release hydrogels
ATE303141T1 (de) Ketoprofen mikrogranulat, verfahren zur herstellung desselben sowie pharmazeutische zusammensetzungen
RS70704A (xx) Čvrst prepart sa odloženim/regulisanim otpuštanjem leka, kao nov sistem za davanje leka, sa smanjenim rizikom od preteranog doziranja
DE60128263D1 (de) Ionenstärkenunabhängige pharmazeutische formulierung mit verzögerter freisetzung

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130624