HK1077755A1 - Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha - Google Patents

Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha

Info

Publication number
HK1077755A1
HK1077755A1 HK05109941A HK05109941A HK1077755A1 HK 1077755 A1 HK1077755 A1 HK 1077755A1 HK 05109941 A HK05109941 A HK 05109941A HK 05109941 A HK05109941 A HK 05109941A HK 1077755 A1 HK1077755 A1 HK 1077755A1
Authority
HK
Hong Kong
Prior art keywords
metformin
agonist
ppar
paralpha
obesity
Prior art date
Application number
HK05109941A
Other languages
English (en)
Inventor
Jean-Louis Junien
Alan Edgar
Evelyne Chaput
Original Assignee
Fournier Lab Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Ireland Ltd filed Critical Fournier Lab Ireland Ltd
Publication of HK1077755A1 publication Critical patent/HK1077755A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK05109941A 2002-11-28 2005-11-08 Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha HK1077755A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02292940A EP1424070A1 (en) 2002-11-28 2002-11-28 Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides
PCT/EP2003/013302 WO2004047831A2 (en) 2002-11-28 2003-11-26 Use of a pparalpha agonist and metformin for decreasing the serum triglycerides

Publications (1)

Publication Number Publication Date
HK1077755A1 true HK1077755A1 (en) 2006-02-24

Family

ID=32241358

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05109941A HK1077755A1 (en) 2002-11-28 2005-11-08 Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha

Country Status (22)

Country Link
US (2) US20060142397A1 (xx)
EP (2) EP1424070A1 (xx)
JP (1) JP2006508995A (xx)
CN (1) CN1777417B (xx)
AT (1) ATE362362T1 (xx)
AU (1) AU2003288175B2 (xx)
BR (1) BR0316810A (xx)
CA (1) CA2507894C (xx)
CY (1) CY1106749T1 (xx)
DE (1) DE60313886T2 (xx)
DK (1) DK1569634T3 (xx)
EA (1) EA009772B1 (xx)
ES (1) ES2287546T3 (xx)
HK (1) HK1077755A1 (xx)
MA (1) MA27553A1 (xx)
MX (1) MXPA05005707A (xx)
NO (1) NO20052549L (xx)
PT (1) PT1569634E (xx)
SI (1) SI1569634T1 (xx)
TN (1) TNSN05148A1 (xx)
WO (1) WO2004047831A2 (xx)
ZA (1) ZA200504345B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
EP1457206A1 (en) * 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Combined use of a fibrate and orlistat for the treatment of obesity
EP1559419A1 (en) * 2004-01-23 2005-08-03 Fournier Laboratories Ireland Limited Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention
FR2896160B1 (fr) * 2006-01-13 2008-04-25 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agonistes du ppar alpha.
US8883721B2 (en) * 2009-05-12 2014-11-11 Mcgill University Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
EP2582715B1 (en) 2010-06-16 2018-11-28 The Administrators of the Tulane Educational Fund Growth hormone secretatogue receptor antagonists and uses thereof
FR3050112B1 (fr) * 2016-04-15 2020-09-04 Soc Civ Immobiliere Gecinq Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
CN107496397A (zh) * 2016-06-14 2017-12-22 重庆安格龙翔医药科技有限公司 一种二甲双胍与非诺贝酸的复合物及其制剂
FR3056908B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
CN111374093A (zh) * 2018-12-28 2020-07-07 高倩 超级肥胖小鼠的构建与鉴定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT323195B (de) * 1973-03-16 1975-06-25 Hurka Wilhelm Verfahren zur herstellung neuer salze von biguaniden
FR2275199A1 (fr) * 1974-06-19 1976-01-16 Cerpha (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif
US5190970A (en) * 1990-10-19 1993-03-02 E. R. Squibb & Sons, Inc. Method for preventing onset of or treating Type II diabetes employing a cholesterol lowering drug alone or in combination with an ace inhibitor
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
EP1011651B1 (en) * 1996-02-02 2005-04-27 Merck & Co., Inc. Method of treating diabetes and related disease states
WO1998005331A2 (en) * 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
FR2774591B1 (fr) * 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
US5942500A (en) * 1998-04-27 1999-08-24 Perry; Stephen C. Dietary composition to reduce dietary fats
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
US6498193B2 (en) * 1999-12-22 2002-12-24 Trustees Of Dartmouth College Treatment for complications of type 2 diabetes
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
AU2003296895A1 (en) * 2002-08-20 2004-05-04 The Regents Of The University Of California Combination therapy for controlling appetites

Also Published As

Publication number Publication date
CN1777417B (zh) 2010-10-06
WO2004047831A2 (en) 2004-06-10
CA2507894C (en) 2011-01-04
EP1424070A1 (en) 2004-06-02
SI1569634T1 (sl) 2007-10-31
EP1569634B8 (en) 2007-08-29
ZA200504345B (en) 2006-08-30
CA2507894A1 (en) 2004-06-10
MA27553A1 (fr) 2005-10-03
JP2006508995A (ja) 2006-03-16
EP1569634A2 (en) 2005-09-07
EP1569634B1 (en) 2007-05-16
CN1777417A (zh) 2006-05-24
DE60313886D1 (de) 2007-06-28
MXPA05005707A (es) 2005-07-26
BR0316810A (pt) 2005-10-18
US20100144874A1 (en) 2010-06-10
AU2003288175B2 (en) 2008-11-13
DE60313886T2 (de) 2008-01-17
AU2003288175A1 (en) 2004-06-18
ES2287546T3 (es) 2007-12-16
DK1569634T3 (da) 2007-09-10
EA009772B1 (ru) 2008-04-28
PT1569634E (pt) 2007-08-22
CY1106749T1 (el) 2012-05-23
ATE362362T1 (de) 2007-06-15
WO2004047831A3 (en) 2005-02-24
US20060142397A1 (en) 2006-06-29
EA200500691A1 (ru) 2005-12-29
NO20052549L (no) 2005-06-10
TNSN05148A1 (fr) 2007-05-14

Similar Documents

Publication Publication Date Title
HK1077755A1 (en) Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha
IL194950A0 (en) Novel, arylsulfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders
AP2223A (en) Pramipexole once-daily dosage form.
HK1081946A1 (en) 11-Beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
EP1474139A4 (en) 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 HEMMER FOR THE TREATMENT OF DIABETES, ADIPOSITAS AND DYSLIPIDEMIA
AU2003299791A1 (en) Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
AU2003281978A1 (en) 2,5-diketopiperazines for the treatment of obesity
IS6251A (is) Not af mónóamín oxíðasa lötum fyrir framleiðslu ályfjum ætluðum til meðhöndlunar á offitu
AP2005003299A0 (en) Process for the treatment of palm waste
AU2003237933A8 (en) Use of compounds having gip activity for the treatment of disorders associated with abnormal loss of cells and/or for the treatment of obesity
ZA200500719B (en) The use of the combination of ciclesonide and antihitamines for the treatment of allergic rhinitis.
AU2003255413A8 (en) Use of lck inhibitor for treatment of immunologic diseases
ZA200501288B (en) Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma.
AU2003279442A8 (en) 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes
IL161989A0 (en) Use of norepinephrine reuptake inhibitors for the treatment of cognitive failure
PT2845594T (pt) Utilização de di-hidroimidazolonas para o tratamento de cães
AU2003270683A8 (en) Compounds for the treatment of premature ejaculation
DE50309647D1 (de) Ng fibrotischer erkrankungen
HRP20041160A2 (en) Novel combination for the treatment of airway disorders
AU2002354698A1 (en) Use of xaa-pro peptidases for the treatment of substance p-related disorders
PL373800A1 (en) Monotherapy for the treatment of amyotrophic lateral sclerosis with cyclooxygenase-2 (cox 2) inhibitor(s)
IL162492A0 (en) Use of alkylphosphocholines for the preventative treatment of protozoandiseases
GB0329357D0 (en) Treatment of materials
AU2003230513A1 (en) Method for durability treatment of a pumpable material as well as a device therefore
ZA200409030B (en) New compounds useful for the treatment of obesity,type ii diabetes and CNS disorders.

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20131126