MA27553A1 - Utilisation d'un agoniste de ppar et de metformine pour diminuer les triglycerides seriques - Google Patents
Utilisation d'un agoniste de ppar et de metformine pour diminuer les triglycerides seriquesInfo
- Publication number
- MA27553A1 MA27553A1 MA28301A MA28301A MA27553A1 MA 27553 A1 MA27553 A1 MA 27553A1 MA 28301 A MA28301 A MA 28301A MA 28301 A MA28301 A MA 28301A MA 27553 A1 MA27553 A1 MA 27553A1
- Authority
- MA
- Morocco
- Prior art keywords
- ppar
- metformin
- agonist
- serum triglycerides
- decrease serum
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title abstract 3
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003105 metformin Drugs 0.000 title abstract 3
- 210000002966 serum Anatomy 0.000 title abstract 3
- 150000003626 triacylglycerols Chemical class 0.000 title abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Utilisation d'un agoniste de PPAR(alpha) et de metformine pour diminuer les triglycérides sériques FOURNIER LABORATORIES IRELAND. La présente invention concerne l'utilisation combinée d'un agoniste de PPAR(alpha) et de metformine pour abaisser les triglycérides sériques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02292940A EP1424070A1 (fr) | 2002-11-28 | 2002-11-28 | Combinaison d'un agoniste de PPAR-alpha et de metformine pour la réduction du taux de triglycérides sériques |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27553A1 true MA27553A1 (fr) | 2005-10-03 |
Family
ID=32241358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28301A MA27553A1 (fr) | 2002-11-28 | 2005-05-26 | Utilisation d'un agoniste de ppar et de metformine pour diminuer les triglycerides seriques |
Country Status (22)
Country | Link |
---|---|
US (2) | US20060142397A1 (fr) |
EP (2) | EP1424070A1 (fr) |
JP (1) | JP2006508995A (fr) |
CN (1) | CN1777417B (fr) |
AT (1) | ATE362362T1 (fr) |
AU (1) | AU2003288175B2 (fr) |
BR (1) | BR0316810A (fr) |
CA (1) | CA2507894C (fr) |
CY (1) | CY1106749T1 (fr) |
DE (1) | DE60313886T2 (fr) |
DK (1) | DK1569634T3 (fr) |
EA (1) | EA009772B1 (fr) |
ES (1) | ES2287546T3 (fr) |
HK (1) | HK1077755A1 (fr) |
MA (1) | MA27553A1 (fr) |
MX (1) | MXPA05005707A (fr) |
NO (1) | NO20052549L (fr) |
PT (1) | PT1569634E (fr) |
SI (1) | SI1569634T1 (fr) |
TN (1) | TNSN05148A1 (fr) |
WO (1) | WO2004047831A2 (fr) |
ZA (1) | ZA200504345B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
EP1457206A1 (fr) * | 2003-03-13 | 2004-09-15 | Fournier Laboratories Ireland Limited | Utilisation combinée d'un fibrate et de l'orlistat pour le traitement de l'obésité |
EP1559419A1 (fr) * | 2004-01-23 | 2005-08-03 | Fournier Laboratories Ireland Limited | Composition pharmaceutique contenant une combinaison de mefformine et d'un fibrate et les procédés pour les obtenir |
FR2896160B1 (fr) * | 2006-01-13 | 2008-04-25 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agonistes du ppar alpha. |
WO2010132580A2 (fr) * | 2009-05-12 | 2010-11-18 | The Administrators Of The Tulane Educational Fund | Procédés d'inhibition de la voie ghréline/récepteur secrétagogue de l'hormone de croissance et leurs utilisations |
US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
WO2011159917A2 (fr) | 2010-06-16 | 2011-12-22 | The Administrators Of The Tulane Educational Fund | Antagonistes du récepteur du secrétagogue de l'hormone de croissance et leurs utilisations |
FR3050112B1 (fr) * | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
CN107496397A (zh) * | 2016-06-14 | 2017-12-22 | 重庆安格龙翔医药科技有限公司 | 一种二甲双胍与非诺贝酸的复合物及其制剂 |
FR3056908B1 (fr) * | 2016-09-30 | 2019-04-19 | Nashpharm | Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie |
CN111374093A (zh) * | 2018-12-28 | 2020-07-07 | 高倩 | 超级肥胖小鼠的构建与鉴定方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT323195B (de) * | 1973-03-16 | 1975-06-25 | Hurka Wilhelm | Verfahren zur herstellung neuer salze von biguaniden |
FR2275199A1 (fr) * | 1974-06-19 | 1976-01-16 | Cerpha | (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif |
US5190970A (en) * | 1990-10-19 | 1993-03-02 | E. R. Squibb & Sons, Inc. | Method for preventing onset of or treating Type II diabetes employing a cholesterol lowering drug alone or in combination with an ace inhibitor |
US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
WO1997027847A1 (fr) * | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Methode de traitement du diabete et d'etats pathologiques associes |
EP0930882A2 (fr) * | 1996-08-02 | 1999-07-28 | Institut Pasteur De Lille | Prevention ou traitement de diabetes non insulinodependants ou de maladies cardiovasculaires avec des modulateurs ppar |
FR2774591B1 (fr) * | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
US5942500A (en) * | 1998-04-27 | 1999-08-24 | Perry; Stephen C. | Dietary composition to reduce dietary fats |
FR2796940B1 (fr) * | 1999-07-26 | 2005-04-08 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
US6498193B2 (en) * | 1999-12-22 | 2002-12-24 | Trustees Of Dartmouth College | Treatment for complications of type 2 diabetes |
US6569879B2 (en) * | 2000-02-18 | 2003-05-27 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
US20030092736A1 (en) * | 2001-05-30 | 2003-05-15 | Cheng Peter T. | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
WO2004034968A2 (fr) * | 2002-08-20 | 2004-04-29 | The Regents Of The University Of California | Polythérapie pour contrôler l'appétit |
-
2002
- 2002-11-28 EP EP02292940A patent/EP1424070A1/fr not_active Withdrawn
-
2003
- 2003-11-26 US US10/536,660 patent/US20060142397A1/en not_active Abandoned
- 2003-11-26 EP EP03780062A patent/EP1569634B8/fr not_active Expired - Lifetime
- 2003-11-26 AT AT03780062T patent/ATE362362T1/de active
- 2003-11-26 WO PCT/EP2003/013302 patent/WO2004047831A2/fr active IP Right Grant
- 2003-11-26 BR BR0316810-7A patent/BR0316810A/pt not_active IP Right Cessation
- 2003-11-26 SI SI200330898T patent/SI1569634T1/sl unknown
- 2003-11-26 CA CA2507894A patent/CA2507894C/fr not_active Expired - Fee Related
- 2003-11-26 DE DE60313886T patent/DE60313886T2/de not_active Expired - Lifetime
- 2003-11-26 DK DK03780062T patent/DK1569634T3/da active
- 2003-11-26 PT PT03780062T patent/PT1569634E/pt unknown
- 2003-11-26 MX MXPA05005707A patent/MXPA05005707A/es active IP Right Grant
- 2003-11-26 AU AU2003288175A patent/AU2003288175B2/en not_active Ceased
- 2003-11-26 ES ES03780062T patent/ES2287546T3/es not_active Expired - Lifetime
- 2003-11-26 EA EA200500691A patent/EA009772B1/ru not_active IP Right Cessation
- 2003-11-26 CN CN2003801044454A patent/CN1777417B/zh not_active Expired - Fee Related
- 2003-11-26 JP JP2004554485A patent/JP2006508995A/ja active Pending
-
2005
- 2005-05-26 MA MA28301A patent/MA27553A1/fr unknown
- 2005-05-26 NO NO20052549A patent/NO20052549L/no not_active Application Discontinuation
- 2005-05-27 ZA ZA200504345A patent/ZA200504345B/en unknown
- 2005-05-27 TN TNP2005000148A patent/TNSN05148A1/fr unknown
- 2005-11-08 HK HK05109941A patent/HK1077755A1/xx not_active IP Right Cessation
-
2007
- 2007-07-20 CY CY20071100972T patent/CY1106749T1/el unknown
-
2010
- 2010-02-12 US US12/705,155 patent/US20100144874A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2507894C (fr) | 2011-01-04 |
CA2507894A1 (fr) | 2004-06-10 |
DE60313886T2 (de) | 2008-01-17 |
AU2003288175B2 (en) | 2008-11-13 |
BR0316810A (pt) | 2005-10-18 |
ZA200504345B (en) | 2006-08-30 |
WO2004047831A2 (fr) | 2004-06-10 |
US20060142397A1 (en) | 2006-06-29 |
US20100144874A1 (en) | 2010-06-10 |
ES2287546T3 (es) | 2007-12-16 |
CN1777417A (zh) | 2006-05-24 |
HK1077755A1 (en) | 2006-02-24 |
CY1106749T1 (el) | 2012-05-23 |
WO2004047831A3 (fr) | 2005-02-24 |
MXPA05005707A (es) | 2005-07-26 |
JP2006508995A (ja) | 2006-03-16 |
AU2003288175A1 (en) | 2004-06-18 |
EP1569634A2 (fr) | 2005-09-07 |
NO20052549L (no) | 2005-06-10 |
PT1569634E (pt) | 2007-08-22 |
EP1424070A1 (fr) | 2004-06-02 |
SI1569634T1 (sl) | 2007-10-31 |
TNSN05148A1 (fr) | 2007-05-14 |
ATE362362T1 (de) | 2007-06-15 |
EA009772B1 (ru) | 2008-04-28 |
DE60313886D1 (de) | 2007-06-28 |
EP1569634B1 (fr) | 2007-05-16 |
DK1569634T3 (da) | 2007-09-10 |
CN1777417B (zh) | 2010-10-06 |
EP1569634B8 (fr) | 2007-08-29 |
EA200500691A1 (ru) | 2005-12-29 |
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