HK1077475A1 - Compositions and methods for cancer diagnosis and therapy - Google Patents
Compositions and methods for cancer diagnosis and therapyInfo
- Publication number
- HK1077475A1 HK1077475A1 HK05111089A HK05111089A HK1077475A1 HK 1077475 A1 HK1077475 A1 HK 1077475A1 HK 05111089 A HK05111089 A HK 05111089A HK 05111089 A HK05111089 A HK 05111089A HK 1077475 A1 HK1077475 A1 HK 1077475A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- mir15
- prostate cancer
- lymphocytic leukemia
- chronic lymphocytic
- cells
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42586402P | 2002-11-13 | 2002-11-13 | |
US46946403P | 2003-05-09 | 2003-05-09 | |
PCT/US2003/035777 WO2004043387A2 (fr) | 2002-11-13 | 2003-11-12 | Compositions et procedes de diagnostic et de therapie du cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1077475A1 true HK1077475A1 (en) | 2006-02-17 |
Family
ID=32314611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05111089A HK1077475A1 (en) | 2002-11-13 | 2005-12-06 | Compositions and methods for cancer diagnosis and therapy |
Country Status (9)
Country | Link |
---|---|
US (4) | US20040152112A1 (fr) |
EP (1) | EP1567007B1 (fr) |
JP (2) | JP4939055B2 (fr) |
CN (1) | CN102304570B (fr) |
AT (1) | ATE546528T1 (fr) |
AU (1) | AU2003291433B2 (fr) |
CA (1) | CA2504605C (fr) |
HK (1) | HK1077475A1 (fr) |
WO (1) | WO2004043387A2 (fr) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004043387A2 (fr) | 2002-11-13 | 2004-05-27 | Thomas Jefferson University | Compositions et procedes de diagnostic et de therapie du cancer |
US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
CA2554818A1 (fr) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers |
CA2566519C (fr) | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micro-arn et utilisations connexes |
US7795419B2 (en) * | 2004-05-26 | 2010-09-14 | Rosetta Genomics Ltd. | Viral and viral associated miRNAs and uses thereof |
EP2290067B1 (fr) | 2004-05-28 | 2014-12-10 | Asuragen, Inc. | Procédés et compositions impliquant du microbe |
US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
CA2576233C (fr) * | 2004-08-10 | 2016-03-15 | Alnylam Pharmaceuticals, Inc. | Conjugue comprenant un antagomir et un ligand |
EP1797183B1 (fr) * | 2004-09-02 | 2012-08-01 | Yale University | Regulation d'oncogenes par des micro-arn |
ES2534304T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
US8192938B2 (en) | 2005-02-24 | 2012-06-05 | The Ohio State University | Methods for quantifying microRNA precursors |
JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物 |
WO2007028030A2 (fr) * | 2005-09-02 | 2007-03-08 | Picobella, Llc | Arn regulateurs oncogenes pour le diagnostic et la therapie |
EP2796554A3 (fr) * | 2005-09-12 | 2014-12-10 | The Ohio State University Research Foundation | Compositions pour la thérapie de cancers associés au gène BCL2 |
CA2624531A1 (fr) * | 2005-10-05 | 2007-04-19 | Carlo M. Croce | Gene wwox, vecteurs renfermant celui-ci et utilisations de ceux-ci dans le traitement de cancer |
EP2487263B1 (fr) * | 2006-01-05 | 2014-03-19 | The Ohio State University Research Foundation | Procédés à base de micro ARN et compositions pour le diagnostic et le traitement des cancers solides du pancréas |
AU2012238336B8 (en) * | 2006-01-05 | 2014-08-07 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
WO2007081720A2 (fr) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Procédés et compositions basés sur des micro-arn et s'appliquant au diagnostic, au pronostic et au traitement du cancer du poumon |
AU2014203454B2 (en) * | 2006-01-05 | 2016-03-17 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
AU2016203848B2 (en) * | 2006-01-05 | 2017-12-14 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
CN101384273B (zh) | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
EP2522750A1 (fr) * | 2006-03-02 | 2012-11-14 | The Ohio State University | Profil d'expression de micro-ARN associé au cancer du pancréas |
ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
US20100113299A1 (en) * | 2008-10-14 | 2010-05-06 | Von Hoff Daniel D | Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type |
BRPI0711011A2 (pt) | 2006-05-18 | 2011-08-23 | Molecular Profiling Inst Inc | método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença |
US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
WO2007147067A2 (fr) * | 2006-06-14 | 2007-12-21 | Rosetta Inpharmatics Llc | Procédés et compositions de régulation de l'évolution du cycle cellulaire |
EP2455493B1 (fr) | 2006-07-13 | 2014-01-08 | The Ohio State University Research Foundation | Procédés basés sur le micro-ARN et compositions pour le diagnostic et le traitement de maladies liées au côlon |
AU2007299804A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | MiR-200 regulated genes and pathways as targets for therapeutic intervention |
US8071292B2 (en) * | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
ES2425416T3 (es) | 2006-11-01 | 2013-10-15 | The Ohio State University Research Foundation | Firma de expresión del microARN para predecir la supervivencia y la metástasis en el carcinoma hepatocelular |
AU2007333110A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miRNA regulated genes and pathways as targets for therapeutic intervention |
JPWO2008090930A1 (ja) * | 2007-01-23 | 2010-05-20 | オリンパス株式会社 | 癌の診断方法 |
CN105256004A (zh) * | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
EP2125032A4 (fr) | 2007-02-20 | 2011-02-23 | Mayo Foundation | Traitement de cancer a l'aide d'acide nucleique viral |
JP2010523156A (ja) * | 2007-04-10 | 2010-07-15 | ナショナル タイワン ユニバーシティ | マイクロrnaによる癌患者における治療後生存の予測 |
CN104195226B (zh) * | 2007-04-30 | 2017-01-11 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
JP5690588B2 (ja) * | 2007-06-08 | 2015-03-25 | アメリカ合衆国 | 肝細胞癌のサブタイプを決定し、肝癌幹細胞を検出するための方法 |
CA2690749A1 (fr) | 2007-06-15 | 2008-12-24 | The Ohio State University Research Foundation | Proteines de fusion all-1 oncogenes pour cibler le traitement de micro-arn regule par drosha |
US8367632B2 (en) | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
CN101835902B (zh) | 2007-08-03 | 2014-03-26 | 俄亥俄州立大学研究基金会 | 编码ncrna的超保守区域 |
EP2183593B1 (fr) | 2007-08-22 | 2016-01-13 | The Ohio State University Research Foundation | Procédés et compositions pour induire une dérégulation de la phosphorylation de epha7 et de erk dans des cas de leucémies humaines aigües |
EP3048177A1 (fr) * | 2007-09-06 | 2016-07-27 | The Ohio State University Research Foundation | Signatures de microarn dans le cancer de l'ovaire humain |
WO2009036332A1 (fr) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Microarn exprimés de manière différentielle dans le cancer du col de l'utérus et leurs utilisations |
KR101666228B1 (ko) | 2007-09-28 | 2016-10-13 | 인트렉손 코포레이션 | 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도 |
CN101861401B (zh) * | 2007-10-11 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于诊断和治疗食管腺癌的方法和组合物 |
AU2008316577B2 (en) | 2007-10-26 | 2014-04-10 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof |
JP5654352B2 (ja) | 2007-11-09 | 2015-01-14 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | miR−15ファミリーのマイクロRNAによる心筋細胞生存及び心臓修復の調節 |
CA2707157A1 (fr) * | 2007-11-30 | 2009-06-04 | The Ohio State University Research Foundation | Profilage et criblage d'expression de micro-arn dans du sang peripherique dans un cancer du poumon |
US8071562B2 (en) | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
WO2009108860A2 (fr) * | 2008-02-28 | 2009-09-03 | The Ohio University Rasearch Foundation | Procédés et compositions à base de micro-arn permettant de diagnostiquer, de pronostiquer et de traiter des troubles liés à la prostate |
AU2009219193A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | MicroRNA signatures associated with human chronic lymphocytic leukemia (CCL) and uses thereof |
US20090233297A1 (en) * | 2008-03-06 | 2009-09-17 | Elizabeth Mambo | Microrna markers for recurrence of colorectal cancer |
EP2271757A2 (fr) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions et procédés liés à mir-16 et à la thérapie contre le cancer de la prostate |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
JP5745401B2 (ja) | 2008-06-11 | 2015-07-08 | アメリカ合衆国 | 肝細胞癌についての予測マーカーとしてのMiR−26ファミリーの使用および療法に対する反応性 |
GB2465088C (en) * | 2008-10-30 | 2016-01-27 | Caris Mpi Inc | miRNA expression in the characterisation and classification of cancer |
CA2742324A1 (fr) * | 2008-10-30 | 2010-06-03 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Procedes d'evaluation de motifs arn |
CA2743211A1 (fr) * | 2008-11-12 | 2010-05-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Procedes et systemes d'utilisation d'exosomes pour determiner des phenotypes |
WO2011109440A1 (fr) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarqueurs pour théranostique |
US8883995B2 (en) | 2009-03-06 | 2014-11-11 | Icahn School Of Medicine At Mount Sinai | Live attenuated influenza virus vaccines comprising microRNA response elements |
JP5812491B2 (ja) | 2009-10-01 | 2015-11-11 | 国立研究開発法人国立がん研究センター | 腫瘍治療剤 |
WO2011063382A1 (fr) | 2009-11-23 | 2011-05-26 | The Ohio State University | Substances et procédés pouvant s'utiliser pour agir sur la croissance, la migration, et l'invasion de cellules tumorales |
US9469876B2 (en) | 2010-04-06 | 2016-10-18 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for metastatic prostate cancer |
WO2012065049A1 (fr) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Matériaux et procédés relatifs aux microarn-21, réparation de désappariement et cancer colorectal |
BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
WO2013040251A2 (fr) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Méthodes et compositions incluant mir-135b, permettant de faire la distinction entre un cancer du pancréas et une maladie pancréatique bénigne |
CA2852066A1 (fr) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methodes et materiaux relatifs au cancer des ovaires |
CA2859430A1 (fr) | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Procedes et compositions se rapportant a mir-21 et mir-29a, a l'inhibition d'exosome, et a la metastase cancereuse |
WO2013106766A2 (fr) * | 2012-01-13 | 2013-07-18 | The Research Foundation Of State University Of New York | Indications thérapeutiques du miarn-1291 |
CN104685065B (zh) | 2012-01-20 | 2017-02-22 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
WO2014030602A1 (fr) | 2012-08-20 | 2014-02-27 | 独立行政法人国立がん研究センター | Agent pour le traitement du cancer |
WO2015067710A2 (fr) * | 2013-11-06 | 2015-05-14 | Universite De Rennes 1 | Tyrp1, un miarn "éponge" naturel, et son utilisation dans le cadre de la prise en charge de l'agressivité du mélanome chez l'être humain |
CN104846086A (zh) * | 2015-05-04 | 2015-08-19 | 四川大学华西第二医院 | 血浆miR-15b作为分子标记物在精子产生与功能评估中的应用 |
CN109295231A (zh) * | 2017-11-03 | 2019-02-01 | 中国医学科学院基础医学研究所 | Nok基因在慢性b淋巴细胞白血病诊断或治疗中的用途 |
WO2023249888A1 (fr) * | 2022-06-21 | 2023-12-28 | Curamir Therapeutics, Inc. | Miarn modifié par cytarabine pour le traitement du cancer |
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US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
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US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
US6140049A (en) * | 1996-11-21 | 2000-10-31 | Genset | Detection and early diagnosis of prostate cancer |
AU4347701A (en) * | 2000-03-01 | 2001-09-12 | Corixa Corp | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
AU2002347035B2 (en) * | 2001-09-28 | 2008-04-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V | Micro-RNA molecules |
WO2004042032A2 (fr) * | 2002-11-01 | 2004-05-21 | The Ohio State University Research Foundation | Anomalies cytogenetiques qui permettent de predire la reponse a un traitement de la leucemie lymphoide chronique |
WO2004043387A2 (fr) * | 2002-11-13 | 2004-05-27 | Thomas Jefferson University | Compositions et procedes de diagnostic et de therapie du cancer |
EP1573009B1 (fr) | 2002-12-18 | 2011-09-21 | Third Wave Technologies, Inc. | Detection de petits acides nucleiques |
US7851150B2 (en) * | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
US20060247193A1 (en) * | 2003-02-10 | 2006-11-02 | National Institute Of Advanced Industrial Science And Technology | Regulation of gene expression by dna interference |
WO2005040419A1 (fr) | 2003-10-14 | 2005-05-06 | Novartis Ag | Jeu ordonne de microechantillons oligonucleotidiques |
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2003
- 2003-11-12 WO PCT/US2003/035777 patent/WO2004043387A2/fr active Application Filing
- 2003-11-12 EP EP03768830A patent/EP1567007B1/fr not_active Expired - Lifetime
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- 2003-11-12 AU AU2003291433A patent/AU2003291433B2/en not_active Ceased
- 2003-11-12 US US10/706,798 patent/US20040152112A1/en not_active Abandoned
- 2003-11-12 AT AT03768830T patent/ATE546528T1/de active
- 2003-11-12 JP JP2005507130A patent/JP4939055B2/ja not_active Expired - Fee Related
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Publication number | Publication date |
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ATE546528T1 (de) | 2012-03-15 |
EP1567007A4 (fr) | 2009-11-11 |
US9006190B2 (en) | 2015-04-14 |
CA2504605A1 (fr) | 2004-05-27 |
US20090123533A1 (en) | 2009-05-14 |
JP2011225570A (ja) | 2011-11-10 |
WO2004043387A2 (fr) | 2004-05-27 |
CN102304570A (zh) | 2012-01-04 |
US7723035B2 (en) | 2010-05-25 |
CN102304570B (zh) | 2015-01-21 |
JP4939055B2 (ja) | 2012-05-23 |
EP1567007A2 (fr) | 2005-08-31 |
US20040152112A1 (en) | 2004-08-05 |
US8557515B2 (en) | 2013-10-15 |
CA2504605C (fr) | 2016-01-19 |
US20100173319A1 (en) | 2010-07-08 |
US20060165659A1 (en) | 2006-07-27 |
WO2004043387A3 (fr) | 2004-11-04 |
EP1567007B1 (fr) | 2012-02-22 |
JP2006506469A (ja) | 2006-02-23 |
AU2003291433B2 (en) | 2008-05-22 |
AU2003291433A1 (en) | 2004-06-03 |
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