HK1075659A1 - A process for producing phenserine and its analog - Google Patents

A process for producing phenserine and its analog

Info

Publication number
HK1075659A1
HK1075659A1 HK05107730A HK05107730A HK1075659A1 HK 1075659 A1 HK1075659 A1 HK 1075659A1 HK 05107730 A HK05107730 A HK 05107730A HK 05107730 A HK05107730 A HK 05107730A HK 1075659 A1 HK1075659 A1 HK 1075659A1
Authority
HK
Hong Kong
Prior art keywords
phenserine
analog
producing
compounds
isocyanate
Prior art date
Application number
HK05107730A
Other languages
English (en)
Inventor
Joerg Bruening
Original Assignee
Axonyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axonyx Inc filed Critical Axonyx Inc
Publication of HK1075659A1 publication Critical patent/HK1075659A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK05107730A 2002-01-09 2005-09-02 A process for producing phenserine and its analog HK1075659A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/042,586 US6495700B1 (en) 2002-01-09 2002-01-09 Process for producing phenserine and its analog
PCT/US2002/039537 WO2003059909A1 (en) 2002-01-09 2002-12-11 A process for producing phenserine and its analog

Publications (1)

Publication Number Publication Date
HK1075659A1 true HK1075659A1 (en) 2005-12-23

Family

ID=21922704

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107730A HK1075659A1 (en) 2002-01-09 2005-09-02 A process for producing phenserine and its analog

Country Status (16)

Country Link
US (1) US6495700B1 (xx)
EP (1) EP1463729B1 (xx)
JP (1) JP2005514459A (xx)
KR (2) KR100712003B1 (xx)
CN (1) CN1301995C (xx)
AT (1) ATE466015T1 (xx)
AU (1) AU2002353102B2 (xx)
BR (1) BRPI0215492A2 (xx)
CA (1) CA2470560C (xx)
DE (1) DE60236207D1 (xx)
HK (1) HK1075659A1 (xx)
HR (1) HRP20040606A2 (xx)
HU (1) HUP0500747A3 (xx)
IL (1) IL162827A0 (xx)
PL (1) PL374240A1 (xx)
WO (1) WO2003059909A1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1689704A2 (en) 2003-10-21 2006-08-16 CoLucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
US20070167509A1 (en) * 2005-06-14 2007-07-19 Joseph Araujo Use of phenserine and analogs to treat behavioral problems and improve trainability
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US20120225922A1 (en) 2011-03-04 2012-09-06 Qr Pharma Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration
US20130096316A1 (en) * 2011-10-14 2013-04-18 Qr Pharma, Inc. Novel Method for Preparation of Bisnorcymerine and Salts Thereof
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US10159648B2 (en) 2015-05-22 2018-12-25 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CA3083015A1 (en) 2017-05-24 2018-11-28 Qr Pharma, Inc. Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans

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IT1109003B (it) * 1977-09-20 1985-12-16 Univ Firenze Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
US5306825A (en) 1984-03-01 1994-04-26 Consiglio Nazionale Delle Ricerche Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina
US5187165A (en) 1987-05-15 1993-02-16 Hoechst-Roussel Pharmaceuticals Inc. Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles
US4900748A (en) 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents
US5260452A (en) 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5077289A (en) 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5177101A (en) 1989-11-30 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5705657A (en) 1991-02-14 1998-01-06 Labochim Laboratorio Chimico Internazionale S.P.A. Isocyanate process for the preparation of 1,3A,8-trimethyl-1,2,3,3A, 8, 8A-hexahydro-pyrrole 2,3-B! indol-5 (3AS, 8AR) -hepthylcarbamate
EP0499959A1 (en) 1991-02-18 1992-08-26 Bromine Compounds Ltd. Process for the manufacture of substituted maleimides
WO1993006105A1 (en) 1991-09-26 1993-04-01 United States Government, As Represented By Secret Substituted phenserines and phenylcarbamates of (-)-eseroline, (-)-n1-noreseroline, and (-)-n1-benzylnoreseroline; as specific inhibitors of acetylcholinesterase
US5206260A (en) 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
US5302721A (en) 1992-07-21 1994-04-12 Hoechst-Roussel Pharmaceuticals Incorporated Method of preparation of physostigmine carbamate derivatives from eseretholes
PH30885A (en) * 1992-07-21 1997-12-23 Hoechst Roussel Pharma Preparation of physostigmie carbamate derivatives from physostigmine.
US5409948A (en) 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
US5665880A (en) 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers

Also Published As

Publication number Publication date
KR20040072711A (ko) 2004-08-18
KR100712003B1 (ko) 2007-05-02
CA2470560C (en) 2007-05-15
EP1463729B1 (en) 2010-04-28
BRPI0215492A2 (pt) 2016-07-05
US6495700B1 (en) 2002-12-17
EP1463729A4 (en) 2005-06-29
AU2002353102B2 (en) 2007-05-24
HUP0500747A3 (en) 2009-05-28
HRP20040606A2 (en) 2004-12-31
HUP0500747A2 (hu) 2005-11-28
IL162827A0 (en) 2005-11-20
DE60236207D1 (de) 2010-06-10
EP1463729A1 (en) 2004-10-06
CN1612880A (zh) 2005-05-04
JP2005514459A (ja) 2005-05-19
WO2003059909A1 (en) 2003-07-24
KR20060097772A (ko) 2006-09-15
CA2470560A1 (en) 2003-07-24
ATE466015T1 (de) 2010-05-15
PL374240A1 (en) 2005-10-03
AU2002353102A1 (en) 2003-07-30
CN1301995C (zh) 2007-02-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101211