HK1057048A1 - Lipids comprising an aminoxy group - Google Patents

Lipids comprising an aminoxy group

Info

Publication number
HK1057048A1
HK1057048A1 HK03109313A HK03109313A HK1057048A1 HK 1057048 A1 HK1057048 A1 HK 1057048A1 HK 03109313 A HK03109313 A HK 03109313A HK 03109313 A HK03109313 A HK 03109313A HK 1057048 A1 HK1057048 A1 HK 1057048A1
Authority
HK
Hong Kong
Prior art keywords
lipids
aminoxy group
group
aminoxy
acting
Prior art date
Application number
HK03109313A
Other languages
English (en)
Inventor
Michael Jorgensen
Michael Keller
Andrew David Miller
Eric Perouzel
Original Assignee
Mitsubishi Chem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/004767 external-priority patent/WO2001048233A1/en
Priority claimed from GB0113781A external-priority patent/GB2372502B/en
Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp
Publication of HK1057048A1 publication Critical patent/HK1057048A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK03109313A 2000-12-12 2003-12-22 Lipids comprising an aminoxy group HK1057048A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2000/004767 WO2001048233A1 (en) 1999-12-23 2000-12-12 Viral core protein-cationic lipid-nucleic acid-delivery complexes
GB0113781A GB2372502B (en) 2000-12-12 2001-06-06 Carbohydrate compounds containing cholesterol and their use
PCT/GB2001/005385 WO2002048170A1 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group

Publications (1)

Publication Number Publication Date
HK1057048A1 true HK1057048A1 (en) 2004-03-12

Family

ID=26243759

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03109313A HK1057048A1 (en) 2000-12-12 2003-12-22 Lipids comprising an aminoxy group

Country Status (11)

Country Link
EP (1) EP1351972B1 (de)
JP (2) JP2004522722A (de)
CN (2) CN1524125A (de)
AT (1) ATE318834T1 (de)
AU (3) AU2002222128B2 (de)
CA (2) CA2431896A1 (de)
DE (1) DE60117465T2 (de)
ES (1) ES2259007T3 (de)
HK (1) HK1057048A1 (de)
RU (2) RU2003120456A (de)
WO (2) WO2002048170A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129121D0 (en) * 2001-12-05 2002-01-23 Ic Vec Ltd Compound
WO2006115416A2 (en) * 2005-04-25 2006-11-02 Ge Healthcare As Liposomes
JP5069920B2 (ja) * 2007-02-08 2012-11-07 公益財団法人東京都医学総合研究所 マンノース６−リン酸−ポリエチレングリコール結合体
GB2458473A (en) 2008-03-17 2009-09-23 Imuthes Ltd 3'-O-allyl- and 3'-O-carboxymethyl- 2'-aminosaccharide derivatives, & amides thereof with peptides, as adjuvants
GB0908963D0 (en) 2009-05-22 2009-07-01 Imuthes Ltd Compositions
EP2668961A4 (de) 2010-11-19 2016-07-06 Univ Sapporo Medical Pharmazeutisches kombinationspräparat
CZ307452B6 (cs) * 2016-11-03 2018-09-05 Vysoká škola chemicko-technologická v Praze Aminooxylipidy pro konstrukci samoskladných liposomálních systémů umožňujících jejich následnou modifikaci biologicky funkčními molekulami

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31160A0 (en) * 1967-12-04 1969-01-29 Bayer Ag Basically substituted oximes of 5h-dibenzo-(a,d)-10,11-dihydro-cyclohepten-5-one and their production
NL6818074A (de) * 1968-12-17 1970-06-19
CH574396A5 (de) * 1969-12-29 1976-04-15 Richter Gedeon Vegyeszet
US4189431A (en) * 1975-08-04 1980-02-19 The Board of Trustees of Leland Stanford Junior University Alkinyl terminating groups in biogenetic-like cyclizations to steroids
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5510510A (en) * 1994-05-10 1996-04-23 Bristol-Meyers Squibb Company Inhibitors of farnesyl protein transferase
US6756054B1 (en) * 1996-05-24 2004-06-29 Ic-Vec Limited Polycationic sterol derivatives as transfection agents
DE69736840T2 (de) * 1996-12-24 2007-08-09 Sirna Therapeutics, Inc., Boulder Synthese von nukleosiden und polynukleotiden

Also Published As

Publication number Publication date
CA2431896A1 (en) 2002-06-20
AU2212802A (en) 2002-06-24
JP2004522722A (ja) 2004-07-29
CA2364392A1 (en) 2002-06-12
CN1524125A (zh) 2004-08-25
AU2002222128B2 (en) 2007-06-21
RU2003120455A (ru) 2005-01-10
ATE318834T1 (de) 2006-03-15
ES2259007T3 (es) 2006-09-16
CN1489597A (zh) 2004-04-14
EP1351972A1 (de) 2003-10-15
EP1351972B1 (de) 2006-03-01
RU2290409C2 (ru) 2006-12-27
CN100482676C (zh) 2009-04-29
DE60117465D1 (de) 2006-04-27
WO2002048380A2 (en) 2002-06-20
RU2003120456A (ru) 2005-01-27
WO2002048380A3 (en) 2002-10-24
DE60117465T2 (de) 2006-11-02
AU2002220894A1 (en) 2002-06-24
WO2002048170A1 (en) 2002-06-20
JP2004520301A (ja) 2004-07-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091205