HK1055941A1 - Factor viia inhibitory (thio) urea derivatives, their preparation and their use. - Google Patents

Factor viia inhibitory (thio) urea derivatives, their preparation and their use.

Info

Publication number
HK1055941A1
HK1055941A1 HK03108194A HK03108194A HK1055941A1 HK 1055941 A1 HK1055941 A1 HK 1055941A1 HK 03108194 A HK03108194 A HK 03108194A HK 03108194 A HK03108194 A HK 03108194A HK 1055941 A1 HK1055941 A1 HK 1055941A1
Authority
HK
Hong Kong
Prior art keywords
factor viia
compounds
preparation
formula
thio
Prior art date
Application number
HK03108194A
Other languages
English (en)
Inventor
Otmar Klingler
Manfred Schudok
Hans-Peter Nestler
Hans Matter
Herman Schreuder
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HK1055941A1 publication Critical patent/HK1055941A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK03108194A 2000-06-06 2003-11-12 Factor viia inhibitory (thio) urea derivatives, their preparation and their use. HK1055941A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00112116A EP1162194A1 (de) 2000-06-06 2000-06-06 Auf Faktor VIIa inhibitorisch wirkende (Thio)-Harnstoff Verbindungen, Verfahren zu deren Herstellung und deren Verwendung
PCT/EP2001/006029 WO2001094301A2 (en) 2000-06-06 2001-05-26 Factor viia inhibitory (thio)urea derivatives, their preparation and their use

Publications (1)

Publication Number Publication Date
HK1055941A1 true HK1055941A1 (en) 2004-01-30

Family

ID=8168926

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03108194A HK1055941A1 (en) 2000-06-06 2003-11-12 Factor viia inhibitory (thio) urea derivatives, their preparation and their use.

Country Status (30)

Country Link
US (1) US6743790B2 (de)
EP (2) EP1162194A1 (de)
JP (1) JP4809570B2 (de)
KR (1) KR101011345B1 (de)
CN (1) CN1208314C (de)
AR (1) AR030936A1 (de)
AU (2) AU2001277494B2 (de)
BR (1) BR0111264A (de)
CA (1) CA2410862C (de)
CZ (1) CZ20023963A3 (de)
DE (1) DE60139320D1 (de)
DK (1) DK1299354T3 (de)
EE (1) EE200200617A (de)
ES (1) ES2330412T3 (de)
HK (1) HK1055941A1 (de)
HR (1) HRP20020961A2 (de)
HU (1) HUP0301631A2 (de)
IL (2) IL153220A0 (de)
MX (1) MXPA02009789A (de)
MY (1) MY129363A (de)
NO (1) NO328546B1 (de)
NZ (1) NZ522960A (de)
PL (1) PL359584A1 (de)
PT (1) PT1299354E (de)
RU (1) RU2286337C2 (de)
SK (1) SK17032002A3 (de)
TW (1) TWI283662B (de)
WO (1) WO2001094301A2 (de)
YU (1) YU89202A (de)
ZA (1) ZA200209018B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4567439B2 (ja) * 2002-04-27 2010-10-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング カルボン酸アミド
AU2003265398A1 (en) * 2002-08-09 2004-02-25 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
JP2007505160A (ja) * 2003-05-20 2007-03-08 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のアシルスルファミド阻害剤
EP1626966A1 (de) * 2003-05-20 2006-02-22 Genentech, Inc. Benzofuran-hemmer des faktors viia
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
AU2004263508A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014534A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
JP4478157B2 (ja) * 2004-10-13 2010-06-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヒドラジド誘導体
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2006089954A2 (en) * 2005-02-24 2006-08-31 Novo Nordisk Health Care Ag Compounds for stabilizing factor vii polypeptide formulations
EP1856091A1 (de) * 2005-02-24 2007-11-21 Novo Nordisk Health Care AG Verbindungen für formulierungen von polypeptiden mit dem stabilisierungsfaktor vii
US20090130085A1 (en) * 2005-02-24 2009-05-21 Novo Nordish Healthcare Ag Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations
WO2006134173A2 (en) 2005-06-17 2006-12-21 Novo Nordisk Health Care Ag Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
RS52030B (en) 2006-03-24 2012-04-30 Eisai R&D Management Co., Ltd. DERIVAT TRIAZOLONA
US8247442B2 (en) * 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
EP2202231A4 (de) * 2007-09-21 2011-09-28 Eisai R&D Man Co Ltd 2,3-dihydroiminoisoindolderivate
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
MX357737B (es) 2011-10-26 2018-07-23 Allergan Inc Derivados de amida de aminoacidos sustituidos con n-urea como moduladores de receptor de tipo peptido receptor de formilo-1(fprl-1) .
CA2870356A1 (en) * 2012-04-16 2013-10-24 Allergan, Inc. (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators
WO2014057069A1 (en) 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide
EP2964214A1 (de) 2013-03-06 2016-01-13 Allergan, Inc. Verwendung von agonisten des formylpeptidrezeptors 2 zur behandlung von hautekrankungen
RU2768730C2 (ru) 2013-03-06 2022-03-24 Аллерган, Инк. Применение агонистов формилпептидного рецептора 2 для лечения воспалительных заболеваний глаз

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
JP3387948B2 (ja) * 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
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WO1995008550A1 (en) * 1993-09-24 1995-03-30 Abbott Laboratories Endothelin antagonists
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US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
EP0880320A4 (de) * 1996-01-30 1999-06-16 Merck & Co Inc Inhibitoren der farnesyl-protein transferase
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EP0987274A1 (de) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Faktor VIIa Inhibitore

Also Published As

Publication number Publication date
CN1427818A (zh) 2003-07-02
NO328546B1 (no) 2010-03-15
AR030936A1 (es) 2003-09-03
RU2286337C2 (ru) 2006-10-27
WO2001094301A2 (en) 2001-12-13
NO20025810L (no) 2002-12-03
EE200200617A (et) 2004-04-15
IL153220A (en) 2008-11-03
NO20025810D0 (no) 2002-12-03
AU7749401A (en) 2001-12-17
HUP0301631A2 (hu) 2003-09-29
HRP20020961A2 (en) 2004-12-31
US20020052417A1 (en) 2002-05-02
NZ522960A (en) 2004-05-28
ES2330412T3 (es) 2009-12-10
BR0111264A (pt) 2003-06-17
JP4809570B2 (ja) 2011-11-09
WO2001094301A3 (en) 2002-04-04
KR20030007911A (ko) 2003-01-23
MXPA02009789A (es) 2003-03-12
EP1162194A1 (de) 2001-12-12
PT1299354E (pt) 2009-10-01
CA2410862C (en) 2009-11-10
CA2410862A1 (en) 2001-12-13
CZ20023963A3 (cs) 2003-03-12
KR101011345B1 (ko) 2011-01-28
PL359584A1 (en) 2004-08-23
CN1208314C (zh) 2005-06-29
YU89202A (sh) 2006-05-25
US6743790B2 (en) 2004-06-01
EP1299354B1 (de) 2009-07-22
DE60139320D1 (de) 2009-09-03
IL153220A0 (en) 2003-07-06
AU2001277494B2 (en) 2006-05-04
MY129363A (en) 2007-03-30
DK1299354T3 (da) 2009-11-16
SK17032002A3 (sk) 2003-05-02
TWI283662B (en) 2007-07-11
ZA200209018B (en) 2003-10-08
EP1299354A2 (de) 2003-04-09
JP2003535844A (ja) 2003-12-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130526