HK1048298A1 - 比卡鲁胺(casodex)及其衍生物以及其中间产物的对映体的不对称合成法 - Google Patents

比卡鲁胺(casodex)及其衍生物以及其中间产物的对映体的不对称合成法 Download PDF

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Publication number
HK1048298A1
HK1048298A1 HK03100367.2A HK03100367A HK1048298A1 HK 1048298 A1 HK1048298 A1 HK 1048298A1 HK 03100367 A HK03100367 A HK 03100367A HK 1048298 A1 HK1048298 A1 HK 1048298A1
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HK
Hong Kong
Prior art keywords
sup
casodex
methods
derivatives
intermediates
Prior art date
Application number
HK03100367.2A
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English (en)
Chinese (zh)
Inventor
Ekwuribe Nnochiri
Original Assignee
Biocon Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Limited filed Critical Biocon Limited
Publication of HK1048298A1 publication Critical patent/HK1048298A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK03100367.2A 1999-10-19 2000-10-18 比卡鲁胺(casodex)及其衍生物以及其中间产物的对映体的不对称合成法 HK1048298A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16041299P 1999-10-19 1999-10-19
US60/160,412 1999-10-19
PCT/US2000/041233 WO2001028990A2 (en) 1999-10-19 2000-10-18 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1048298A1 true HK1048298A1 (zh) 2003-03-28

Family

ID=22576803

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100367.2A HK1048298A1 (zh) 1999-10-19 2000-10-18 比卡鲁胺(casodex)及其衍生物以及其中间产物的对映体的不对称合成法

Country Status (18)

Country Link
US (2) US6583306B1 (enExample)
EP (1) EP1222165A2 (enExample)
JP (1) JP5112583B2 (enExample)
KR (1) KR20020091047A (enExample)
CN (1) CN1409702A (enExample)
AU (1) AU1968601A (enExample)
BR (1) BR0014889A (enExample)
CA (1) CA2387570A1 (enExample)
CZ (1) CZ20021340A3 (enExample)
HK (1) HK1048298A1 (enExample)
HU (1) HUP0203785A2 (enExample)
IL (2) IL149056A0 (enExample)
MX (1) MXPA02003884A (enExample)
NO (1) NO20021831L (enExample)
NZ (1) NZ518392A (enExample)
PL (1) PL354620A1 (enExample)
WO (1) WO2001028990A2 (enExample)
ZA (1) ZA200202947B (enExample)

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US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
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US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
PT1463497E (pt) 2001-12-06 2011-12-20 Gtx Inc Tratamento do desgaste muscular com moduladores selectivos do receptor de androgénios
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JP4677516B2 (ja) 2002-02-07 2011-04-27 ユニバーシティ オブ テネシー リサーチ ファウンデーション Ｓａｒｍを用いた前立腺肥大症治療
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
ES2528764T3 (es) 2002-02-28 2015-02-12 University Of Tennessee Research Foundation Moduladores selectivos multisustituidos del receptor de andrógeno y métodos de uso de los mismos
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
DE10222104A1 (de) * 2002-05-17 2003-12-04 Helm Ag Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
US7022870B2 (en) 2002-06-17 2006-04-04 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
EP1402924B1 (de) * 2002-09-04 2008-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung eines Mittel zur Therapie der Herzhypertrophie
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
CN1726034A (zh) 2002-10-15 2006-01-25 田纳西大学研究基金会 亚甲基桥连的选择性雄激素受体调节剂及其应用方法
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
EA200501761A1 (ru) 2003-12-16 2006-04-28 Джи Ти Икс, ИНК. Пролекарственные формы селективных модуляторов андрогеновых рецепторов и способы их применения
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
KR101264820B1 (ko) 2006-08-24 2013-05-22 유니버시티 오브 테네시 리서치 파운데이션 치환된 아실아닐리드 및 그의 사용 방법
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
ITBO20090236A1 (it) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche Procedimento per la sintesi di composti per il trattamento del tumore alla prostata
US8741951B2 (en) 2009-04-10 2014-06-03 CNR—Consiglio Nazionale Delle Ricerche Non-steroidal compounds for androgen receptor modulation
WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
JP6226978B2 (ja) 2012-07-13 2017-11-08 ジーティーエックス・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）によりアンドロゲン受容体（ａｒ）陽性乳癌を処置する方法
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
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US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
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Also Published As

Publication number Publication date
NZ518392A (en) 2004-02-27
BR0014889A (pt) 2002-12-31
CN1409702A (zh) 2003-04-09
WO2001028990A3 (en) 2001-09-07
ZA200202947B (en) 2003-09-23
EP1222165A2 (en) 2002-07-17
US7022869B2 (en) 2006-04-04
CZ20021340A3 (cs) 2002-08-14
KR20020091047A (ko) 2002-12-05
AU1968601A (en) 2001-04-30
WO2001028990A2 (en) 2001-04-26
IL149056A (en) 2011-05-31
JP2003512351A (ja) 2003-04-02
IL149056A0 (en) 2002-11-10
US6583306B1 (en) 2003-06-24
NO20021831D0 (no) 2002-04-18
CA2387570A1 (en) 2001-04-26
PL354620A1 (en) 2004-02-09
US20040030130A1 (en) 2004-02-12
JP5112583B2 (ja) 2013-01-09
HUP0203785A2 (hu) 2003-04-28
NO20021831L (no) 2002-06-19
MXPA02003884A (es) 2004-09-06

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