HK1036978A1 - Enantioselective synthesis - Google Patents

Enantioselective synthesis

Info

Publication number
HK1036978A1
HK1036978A1 HK01107381A HK01107381A HK1036978A1 HK 1036978 A1 HK1036978 A1 HK 1036978A1 HK 01107381 A HK01107381 A HK 01107381A HK 01107381 A HK01107381 A HK 01107381A HK 1036978 A1 HK1036978 A1 HK 1036978A1
Authority
HK
Hong Kong
Prior art keywords
enantioselective synthesis
xiv
formula
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
HK01107381A
Other languages
English (en)
Inventor
Richard W Draper
Radha V Iyer
Yuelie Lu
Eugene J Vater
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1036978A1 publication Critical patent/HK1036978A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HK01107381A 1998-08-14 2001-10-22 Enantioselective synthesis HK1036978A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13421698A 1998-08-14 1998-08-14
PCT/US1999/016711 WO2000009493A1 (en) 1998-08-14 1999-08-12 Enantioselective synthesis

Publications (1)

Publication Number Publication Date
HK1036978A1 true HK1036978A1 (en) 2002-01-25

Family

ID=22462296

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107381A HK1036978A1 (en) 1998-08-14 2001-10-22 Enantioselective synthesis

Country Status (11)

Country Link
EP (1) EP1104414B1 (zh)
JP (2) JP3684332B2 (zh)
CN (1) CN1146554C (zh)
AT (1) ATE232525T1 (zh)
AU (1) AU5459399A (zh)
CA (1) CA2340343C (zh)
DE (1) DE69905376T2 (zh)
ES (1) ES2188222T3 (zh)
HK (1) HK1036978A1 (zh)
WO (1) WO2000009493A1 (zh)
ZA (1) ZA200100875B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS56042B1 (sr) 2010-06-10 2017-09-29 Seragon Pharmaceuticals Inc Modulatori estrogenih receptora i njihove upotrebe
US9193714B2 (en) 2011-12-14 2015-11-24 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof
AU2012353660A1 (en) 2011-12-16 2014-06-12 Olema Pharmaceuticals, Inc. Novel benzopyran compounds, compositions and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5254568A (en) * 1990-08-09 1993-10-19 Council Of Scientific & Industrial Research Benzopyrans as antiestrogenic agents
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5407947A (en) * 1993-11-05 1995-04-18 Eli Lilly And Company Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans
AU8102498A (en) * 1997-07-09 1999-02-08 Central Drug Research Institute Preparation of diaryl-benzopyrans
WO1999002512A1 (en) * 1997-07-09 1999-01-21 Novo Nordisk A/S Dl-2,3-diaryl-2h-1-benzopyrans
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

Also Published As

Publication number Publication date
CN1322200A (zh) 2001-11-14
CA2340343C (en) 2007-04-24
WO2000009493A1 (en) 2000-02-24
JP4461048B2 (ja) 2010-05-12
DE69905376D1 (de) 2003-03-20
ATE232525T1 (de) 2003-02-15
JP3684332B2 (ja) 2005-08-17
CA2340343A1 (en) 2000-02-24
DE69905376T2 (de) 2003-10-09
ZA200100875B (en) 2002-06-26
EP1104414A1 (en) 2001-06-06
EP1104414B1 (en) 2003-02-12
CN1146554C (zh) 2004-04-21
AU5459399A (en) 2000-03-06
ES2188222T3 (es) 2003-06-16
JP2002522533A (ja) 2002-07-23
JP2005206610A (ja) 2005-08-04

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170812