HK1034971A1 - Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides - Google Patents

Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

Info

Publication number
HK1034971A1
HK1034971A1 HK01105743A HK01105743A HK1034971A1 HK 1034971 A1 HK1034971 A1 HK 1034971A1 HK 01105743 A HK01105743 A HK 01105743A HK 01105743 A HK01105743 A HK 01105743A HK 1034971 A1 HK1034971 A1 HK 1034971A1
Authority
HK
Hong Kong
Prior art keywords
preparing enantiomerically
oxides
enriched tetrahydrobenzothiepine
enriched
tetrahydrobenzothiepine oxides
Prior art date
Application number
HK01105743A
Other languages
English (en)
Inventor
James Li
Ching-Cheng Wang
David B Reitz
Victor Snieckus
Horng-Chih Huang
Andrew J Carpenter
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of HK1034971A1 publication Critical patent/HK1034971A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK01105743A 1997-12-19 2001-08-15 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides HK1034971A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6817097P 1997-12-19 1997-12-19
PCT/US1998/026216 WO1999032478A1 (en) 1997-12-19 1998-12-16 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

Publications (1)

Publication Number Publication Date
HK1034971A1 true HK1034971A1 (en) 2001-11-09

Family

ID=22080853

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01105743A HK1034971A1 (en) 1997-12-19 2001-08-15 Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

Country Status (19)

Country Link
US (2) US6369220B1 (ru)
EP (1) EP1042314B1 (ru)
JP (1) JP2001526284A (ru)
KR (1) KR20010015884A (ru)
CN (2) CN1106395C (ru)
AT (1) ATE234829T1 (ru)
AU (1) AU1721399A (ru)
BR (1) BR9814300A (ru)
DE (1) DE69812419T2 (ru)
DK (1) DK1042314T3 (ru)
ES (1) ES2195428T3 (ru)
HK (1) HK1034971A1 (ru)
HU (1) HUP0101193A3 (ru)
IL (1) IL136864A (ru)
PT (1) PT1042314E (ru)
RU (1) RU2236406C2 (ru)
UA (1) UA67764C2 (ru)
WO (1) WO1999032478A1 (ru)
ZA (1) ZA9811648B (ru)

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US6740663B2 (en) * 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
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EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601744B (zh) 2016-02-09 2022-01-04 阿尔比里奥公司 口服考来烯胺制剂及其用途
RU2750937C2 (ru) 2016-02-09 2021-07-06 Альбирео Аб Пероральный состав холестирамина и его применение
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
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US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
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US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
JP2022520121A (ja) 2019-02-12 2022-03-28 ミルム ファーマシューティカルズ インコーポレイテッド 胆汁うっ滞を治療する方法
CN114786772B (zh) 2019-12-04 2024-04-09 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023504645A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
EP4069247A1 (en) 2019-12-04 2022-10-12 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
JP2023537285A (ja) 2020-08-03 2023-08-31 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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JP2024500309A (ja) 2020-12-04 2024-01-09 アルビレオ エービー ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用
US20240116891A1 (en) * 2022-09-14 2024-04-11 Mirum Pharmaceuticals, Inc. Maralixibat solid forms, intermediates and processes of making same

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IT1249318B (it) 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
DK0781278T3 (da) * 1994-09-13 2001-04-17 Monsanto Co Nye benzothiepiner, som har aktivitet som inhibitorer af ileal galdsyretransport og taurocholatoptagelse
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
ATE303378T1 (de) 1996-03-11 2005-09-15 Searle Llc Benzothiepinen mit wirkung als inhibitoren des ileumgallensäuretransports und der taurocholate- aufnahme

Also Published As

Publication number Publication date
CN1284953A (zh) 2001-02-21
ZA9811648B (en) 1999-12-20
CN1439638A (zh) 2003-09-03
US6875877B2 (en) 2005-04-05
IL136864A (en) 2004-07-25
US20020188119A1 (en) 2002-12-12
UA67764C2 (ru) 2004-07-15
EP1042314A1 (en) 2000-10-11
DK1042314T3 (da) 2003-07-14
DE69812419D1 (de) 2003-04-24
KR20010015884A (ko) 2001-02-26
US6369220B1 (en) 2002-04-09
AU1721399A (en) 1999-07-12
BR9814300A (pt) 2002-02-05
WO1999032478A1 (en) 1999-07-01
ES2195428T3 (es) 2003-12-01
HUP0101193A3 (en) 2001-12-28
PT1042314E (pt) 2003-07-31
IL136864A0 (en) 2001-06-14
CN1106395C (zh) 2003-04-23
DE69812419T2 (de) 2003-08-14
HUP0101193A2 (hu) 2001-08-28
RU2236406C2 (ru) 2004-09-20
JP2001526284A (ja) 2001-12-18
ATE234829T1 (de) 2003-04-15
EP1042314B1 (en) 2003-03-19

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20071216