HK1028788A1 - Ribozymal nucleic acids cleaving ccr5 or cxcr4. - Google Patents

Ribozymal nucleic acids cleaving ccr5 or cxcr4.

Info

Publication number
HK1028788A1
HK1028788A1 HK00108017A HK00108017A HK1028788A1 HK 1028788 A1 HK1028788 A1 HK 1028788A1 HK 00108017 A HK00108017 A HK 00108017A HK 00108017 A HK00108017 A HK 00108017A HK 1028788 A1 HK1028788 A1 HK 1028788A1
Authority
HK
Hong Kong
Prior art keywords
ccr5
cxcr4
cleaving
nucleic acids
ribozymal
Prior art date
Application number
HK00108017A
Other languages
English (en)
Inventor
Peter Anthony Minter Eagles
Richard Qihao Zheng
Original Assignee
King S College London
Queen Mary & Westfield College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800870.9A external-priority patent/GB9800870D0/en
Priority claimed from GBGB9828659.4A external-priority patent/GB9828659D0/en
Application filed by King S College London, Queen Mary & Westfield College filed Critical King S College London
Publication of HK1028788A1 publication Critical patent/HK1028788A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/127—DNAzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
HK00108017A 1998-01-15 2000-12-13 Ribozymal nucleic acids cleaving ccr5 or cxcr4. HK1028788A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9800870.9A GB9800870D0 (en) 1998-01-15 1998-01-15 Ribozymal nucleic acid
GBGB9828659.4A GB9828659D0 (en) 1998-12-23 1998-12-23 Ribozymal nucleic acid
PCT/GB1999/000134 WO1999036518A1 (en) 1998-01-15 1999-01-15 Ribozymal nucleic acids cleaving ccr5 or cxcr4

Publications (1)

Publication Number Publication Date
HK1028788A1 true HK1028788A1 (en) 2001-03-02

Family

ID=26312954

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00108017A HK1028788A1 (en) 1998-01-15 2000-12-13 Ribozymal nucleic acids cleaving ccr5 or cxcr4.

Country Status (11)

Country Link
US (1) US6916653B2 (xx)
EP (1) EP1045901B1 (xx)
JP (1) JP4312957B2 (xx)
AT (1) ATE281518T1 (xx)
AU (1) AU763325B2 (xx)
CA (1) CA2317895A1 (xx)
DE (1) DE69921609T2 (xx)
DK (1) DK1045901T3 (xx)
ES (1) ES2233017T3 (xx)
HK (1) HK1028788A1 (xx)
WO (1) WO1999036518A1 (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6100087A (en) * 1998-03-11 2000-08-08 City Of Hope Ribozymes targeted to human CCR5 mRNA
EP1179082A2 (en) * 1999-05-21 2002-02-13 Oxford Biomedica (UK) Limited Improved retroviral production by inhibition of the enveloppe cell receptor
JP2002325573A (ja) * 2001-04-27 2002-11-12 Japan Science & Technology Corp ベクター
EP2000160A3 (en) * 2002-10-30 2009-03-11 Gambro Lundia AB Method and apparatuses for determining the efficiency of dialysis
GB0522578D0 (en) * 2005-11-04 2005-12-14 King S College London Ribozymal nucleic acid
CA2640080A1 (en) 2006-02-02 2008-03-13 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
US9732337B2 (en) 2009-06-16 2017-08-15 The United Stated of America, as represented by the Secretary, Department of Health & Human Services RNA nanoparticles and nanotubes
EP2476441A1 (en) 2011-01-13 2012-07-18 Universitat Autònoma De Barcelona Methods and reagents for efficient and targeted delivery of therapeutic molecules to CXCR4 cells
AU2014321443B2 (en) 2013-09-17 2020-07-09 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Multifunctional RNA nanoparticles and methods of use
US10517890B2 (en) 2014-05-06 2019-12-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles
EP3050574B1 (en) 2015-01-28 2019-10-09 Universite De Bordeaux Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037746A (en) 1986-12-03 1991-08-06 University Patents, Inc. RNA ribozyme polymerases, and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
KR960703170A (ko) 1993-06-23 1996-06-19 알버트 디. 프리센. 안티센스 올리고뉴클레오티드 및 인간면역결핍바이러스감염에서 그것의 치료적이용(antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US5824519A (en) * 1995-11-08 1998-10-20 Medical University Of South Carolina Tissue-specific and target RNA-specific ribozymes
AU1834197A (en) 1996-01-30 1997-08-22 National Institutes Of Health, The Cells expressing both human cd4 and cxcr4
EP0910653A2 (en) 1996-04-26 1999-04-28 University Of Pittsburgh A cytoplasmic gene expression system which utilizes a prokaryotic rna polymerase autogene
US5910628A (en) 1996-05-20 1999-06-08 Iowa State University Research Foundation, Inc. Cap-independent translation sequences derived from barley yellow dwarf virus
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
WO1997045543A2 (en) * 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Cc chemokine receptor 5, antibodies thereto, transgenic animals
AU4055897A (en) * 1996-08-08 1998-02-25 Aaron Diamond Aids Research Center, The Hiv coreceptor mutants
US5939538A (en) * 1996-10-25 1999-08-17 Immusol Incorporated Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA
AU6271598A (en) 1997-02-06 1998-08-26 Epoch Pharmaceuticals, Inc. Targeted modification of the ccr-5 gene

Also Published As

Publication number Publication date
DK1045901T3 (da) 2005-02-28
EP1045901B1 (en) 2004-11-03
US20020061585A1 (en) 2002-05-23
ES2233017T3 (es) 2005-06-01
WO1999036518A1 (en) 1999-07-22
DE69921609T2 (de) 2005-10-27
AU763325B2 (en) 2003-07-17
US6916653B2 (en) 2005-07-12
AU2067799A (en) 1999-08-02
EP1045901A1 (en) 2000-10-25
ATE281518T1 (de) 2004-11-15
JP4312957B2 (ja) 2009-08-12
JP2002508958A (ja) 2002-03-26
CA2317895A1 (en) 1999-07-22
DE69921609D1 (de) 2004-12-09

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Legal Events

Date Code Title Description
CHRG Changes in the register

Free format text: FROM BTG INTERNATIONAL LIMITED ? TO KING S COLLEGE LONDON, QUEEN MARY AND WESTFIELD COLLEGE ??

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100115