HK1028239A1 - Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase - Google Patents

Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Info

Publication number
HK1028239A1
HK1028239A1 HK00106505A HK00106505A HK1028239A1 HK 1028239 A1 HK1028239 A1 HK 1028239A1 HK 00106505 A HK00106505 A HK 00106505A HK 00106505 A HK00106505 A HK 00106505A HK 1028239 A1 HK1028239 A1 HK 1028239A1
Authority
HK
Hong Kong
Prior art keywords
protein transferase
farnesyl protein
cyclohepta
benzo
inhibition
Prior art date
Application number
HK00106505A
Other languages
English (en)
Inventor
Alan B Cooper
Ronald J Doll
Anil K Saksena
Viyyoor M Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1028239A1 publication Critical patent/HK1028239A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK00106505A 1997-06-17 2000-10-12 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase HK1028239A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87745797A 1997-06-17 1997-06-17
PCT/US1998/011497 WO1998057944A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
HK1028239A1 true HK1028239A1 (en) 2001-02-09

Family

ID=25370002

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00106505A HK1028239A1 (en) 1997-06-17 2000-10-12 Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase

Country Status (14)

Country Link
EP (1) EP0993454B1 (ja)
JP (1) JP2002504146A (ja)
KR (1) KR20010013882A (ja)
CN (1) CN1267293A (ja)
AT (1) ATE248831T1 (ja)
AU (1) AU754066B2 (ja)
CA (1) CA2293373C (ja)
DE (1) DE69817826T2 (ja)
ES (1) ES2205501T3 (ja)
HK (1) HK1028239A1 (ja)
HU (1) HUP0002863A3 (ja)
IL (1) IL133391A0 (ja)
NZ (1) NZ501614A (ja)
WO (1) WO1998057944A1 (ja)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0642514B1 (en) * 1992-03-27 1997-05-21 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
DK0723538T3 (da) * 1993-10-15 2002-03-18 Schering Corp Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
HUP0002863A3 (en) 2001-04-28
DE69817826T2 (de) 2004-07-15
NZ501614A (en) 2001-10-26
ES2205501T3 (es) 2004-05-01
EP0993454A1 (en) 2000-04-19
IL133391A0 (en) 2001-04-30
AU7815298A (en) 1999-01-04
AU754066B2 (en) 2002-11-07
JP2002504146A (ja) 2002-02-05
EP0993454B1 (en) 2003-09-03
CA2293373A1 (en) 1998-12-23
DE69817826D1 (de) 2003-10-09
CN1267293A (zh) 2000-09-20
KR20010013882A (ko) 2001-02-26
ATE248831T1 (de) 2003-09-15
HUP0002863A2 (hu) 2001-01-29
CA2293373C (en) 2008-09-23
WO1998057944A1 (en) 1998-12-23

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070615