HK1016598A1 - Pyrrolidine derivatives having phospholipase a2 inhibitory activity - Google Patents

Pyrrolidine derivatives having phospholipase a2 inhibitory activity

Info

Publication number
HK1016598A1
HK1016598A1 HK99101691A HK99101691A HK1016598A1 HK 1016598 A1 HK1016598 A1 HK 1016598A1 HK 99101691 A HK99101691 A HK 99101691A HK 99101691 A HK99101691 A HK 99101691A HK 1016598 A1 HK1016598 A1 HK 1016598A1
Authority
HK
Hong Kong
Prior art keywords
phospholipase
inhibitory activity
pyrrolidine derivatives
inhibiting
activity
Prior art date
Application number
HK99101691A
Other languages
English (en)
Inventor
Mitsuaki Ohtani
Toshiyuki Kato
Fumihiko Watanabe
Kaoru Seno
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of HK1016598A1 publication Critical patent/HK1016598A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
HK99101691A 1995-07-31 1999-04-20 Pyrrolidine derivatives having phospholipase a2 inhibitory activity HK1016598A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19464895 1995-07-31
PCT/JP1996/002079 WO1997005135A1 (fr) 1995-07-31 1996-07-25 Derives de pyrrolidine possedant une activite d'inhibition de la phospholipase a¿2?

Publications (1)

Publication Number Publication Date
HK1016598A1 true HK1016598A1 (en) 1999-11-05

Family

ID=16328012

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99101691A HK1016598A1 (en) 1995-07-31 1999-04-20 Pyrrolidine derivatives having phospholipase a2 inhibitory activity

Country Status (17)

Country Link
US (1) US5955616A (pt)
EP (1) EP0848004B1 (pt)
JP (1) JP3923079B2 (pt)
KR (1) KR100429950B1 (pt)
CN (1) CN1064682C (pt)
AT (1) ATE236154T1 (pt)
AU (1) AU707537B2 (pt)
BR (1) BR9609744A (pt)
CA (1) CA2227829A1 (pt)
DE (1) DE69627164T2 (pt)
DK (1) DK0848004T3 (pt)
ES (1) ES2196163T3 (pt)
HK (1) HK1016598A1 (pt)
MX (1) MX9800804A (pt)
PT (1) PT848004E (pt)
TR (1) TR199800157T1 (pt)
WO (1) WO1997005135A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
EP0923545A1 (en) 1996-08-17 1999-06-23 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
BR9712792A (pt) * 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
TW577875B (en) * 1997-01-31 2004-03-01 Shionogi & Co Pyrrolidine derivatives with inhibitory activity for phospholipase A2
WO1999024415A1 (fr) * 1997-11-12 1999-05-20 Institute Of Medicinal Molecular Design, Inc. Agonistes du recepteur du retinoide
EP1062216A1 (en) * 1998-02-25 2000-12-27 Genetics Institute, Inc. Inhibitors of phospholipase a2
WO2001002394A1 (en) * 1999-07-01 2001-01-11 Geron Corporation Substituted indole compounds and their use for the treatment of cancer
US7026334B1 (en) 1999-07-26 2006-04-11 Shionogi & Co., Ltd. Thiazolidine compounds and pharmaceutical compositions exhibiting thrombopoietin receptor agonism
CN1217699C (zh) * 1999-10-22 2005-09-07 盐野义制药株式会社 心律失常的预防剂或药物
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
EP1277743A4 (en) * 2000-03-28 2005-03-23 Nippon Soda Co OXA DERIVED (THIA) ZOLIDINE AND ANTI-INFLAMMATORY DRUG
CA2402123A1 (en) * 2000-04-24 2001-11-01 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6768008B2 (en) * 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6958355B2 (en) 2000-04-24 2005-10-25 Aryx Therapeutics, Inc. Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
BR0112656A (pt) * 2000-07-19 2003-06-24 Hoffmann La Roche Compostos, composições farmacêuticas que contêm os mesmos, utilização desses compostos,: processo para tratamento terapêutico e/ou profilático e processo para a preparação desses compostos
AU2001294673A1 (en) * 2000-09-21 2002-04-02 Aryx Therapeutics Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, andatherosclerosis
CA2435143A1 (en) * 2001-01-26 2002-08-01 Shionogi & Co., Ltd. Halogen compounds having thrombopoietin receptor agonism
US20060047000A1 (en) * 2001-04-24 2006-03-02 Aryx Therapeutics, Inc. Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
WO2003000668A1 (en) * 2001-06-25 2003-01-03 Nippon Soda Co., Ltd. Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents
FR2833261B1 (fr) * 2001-12-06 2004-07-02 Yang Ji Chemical Company Ltd Nouveaux composes inhibiteurs specifiques de la phospholipase a2 secretee non pancreatique humaine du groupe ii
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
BRPI0508036A (pt) 2004-02-27 2007-07-17 Hoffmann La Roche derivados fundidos de pirazola
DE102004014945A1 (de) * 2004-03-26 2005-10-13 Merck Patent Gmbh Prolinylderivate
US20060293374A1 (en) * 2005-06-24 2006-12-28 Beers Scott A Substituted isothiazolones
EP2346821A1 (en) * 2008-10-17 2011-07-27 Exelixis, Inc. Sphingosine-1-phosphate receptor antagonists
KR101982669B1 (ko) * 2011-05-26 2019-05-27 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Ape1 매개된 질환을 치료하기 위한 퀴논 화합물
AU2011372747B2 (en) * 2011-07-04 2016-12-22 Rottapharm Biotech S.R.L. Cyclic amine derivatives as EP4 receptor antagonists
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
JPS6184094A (ja) * 1984-10-01 1986-04-28 日本電気株式会社 多層プリント配線板の検査用パタ−ン
JPS6212776A (ja) * 1985-07-10 1987-01-21 Taiho Yakuhin Kogyo Kk ロ−ダニン誘導体
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
GB9025987D0 (en) * 1990-11-29 1991-01-16 Ilford Ltd Merocyanine dyes
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2133413C (en) * 1992-04-07 2001-04-10 John Eugene Macor Indole derivatives as 5-ht1 antagonists
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
KR950704278A (ko) * 1992-10-15 1995-11-17 시오노 요시히꼬 세포내 포스포리파제 a₂저해 활성을 갖는 옥사졸리논 유도체(oxazolinone derivative having intracellular phospholipase a₂inhibitor activity)
US5521202A (en) * 1993-04-07 1996-05-28 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivatives and pharmaceutical compositions containing the same
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
JPH07138258A (ja) * 1993-11-16 1995-05-30 Taiho Yakuhin Kogyo Kk チアゾリジンジオン誘導体又はその塩
US5519134A (en) * 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers

Also Published As

Publication number Publication date
DE69627164T2 (de) 2004-01-29
CA2227829A1 (en) 1997-02-13
EP0848004A4 (en) 1999-11-17
JP3923079B2 (ja) 2007-05-30
AU6530896A (en) 1997-02-26
BR9609744A (pt) 1999-03-02
MX9800804A (es) 1998-07-31
TR199800157T1 (xx) 1998-06-22
DE69627164D1 (de) 2003-05-08
ATE236154T1 (de) 2003-04-15
CN1064682C (zh) 2001-04-18
AU707537B2 (en) 1999-07-15
PT848004E (pt) 2003-07-31
ES2196163T3 (es) 2003-12-16
EP0848004B1 (en) 2003-04-02
US5955616A (en) 1999-09-21
WO1997005135A1 (fr) 1997-02-13
EP0848004A1 (en) 1998-06-17
KR100429950B1 (ko) 2004-06-16
DK0848004T3 (da) 2003-07-21
KR19990036041A (ko) 1999-05-25
CN1197458A (zh) 1998-10-28

Similar Documents

Publication Publication Date Title
HK1016598A1 (en) Pyrrolidine derivatives having phospholipase a2 inhibitory activity
ES2182852T3 (es) Derivados de prolinamida.
AU2002211216A1 (en) Substituted aminopropoxyaryl derivatives useful as agonists for lxr
AU5577598A (en) Pyrrolidine derivatives having phospholipase a2 inhibitory activity
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
PL340658A1 (en) Derivatives of biphenylamidine
AU1171897A (en) 1-methylcarbapenem derivatives
EP1026162A4 (en) ANTI-RHUMATISMAL AGENT
HU9501466D0 (en) Glycopyranoside benzothiophenes
ES2185599T3 (es) Preparacion de intermediarios de la imidazodiacepina.
ES2196174T3 (es) `derivados de sesquiterpeno de actividad antiviral.
AU7020996A (en) UCK14 compounds
BG100531A (en) Method for inhibition of photodecomposition of 3-substituted 2-oxindoles
ATE166058T1 (de) Neue verbindung, leustroducsin h, ihre herstellung und therapeutische verwendung
AU4628399A (en) Polyhydroalkylpyrazine derivatives and their preparation and medicines containing them

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080725