HK1016153A1 - Butyrate prodrugs of lactic acid - Google Patents

Butyrate prodrugs of lactic acid

Info

Publication number
HK1016153A1
HK1016153A1 HK99101097A HK99101097A HK1016153A1 HK 1016153 A1 HK1016153 A1 HK 1016153A1 HK 99101097 A HK99101097 A HK 99101097A HK 99101097 A HK99101097 A HK 99101097A HK 1016153 A1 HK1016153 A1 HK 1016153A1
Authority
HK
Hong Kong
Prior art keywords
methods
lactic acid
prodrugs
agents
alone
Prior art date
Application number
HK99101097A
Other languages
English (en)
Inventor
Roger D Tung
Biqin Li
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/540,345 external-priority patent/US5883123A/en
Priority claimed from US08/640,260 external-priority patent/US5912269A/en
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HK1016153A1 publication Critical patent/HK1016153A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C07C69/68—Lactic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK99101097A 1995-10-06 1999-03-16 Butyrate prodrugs of lactic acid HK1016153A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/540,345 US5883123A (en) 1995-10-06 1995-10-06 Butyrate prodrugs derived from lactic acid
US08/640,260 US5912269A (en) 1996-04-30 1996-04-30 Butyrate prodrugs derived from lactic acid
PCT/US1996/015660 WO1997012855A1 (en) 1995-10-06 1996-09-30 Butyrate prodrugs of lactic acid

Publications (1)

Publication Number Publication Date
HK1016153A1 true HK1016153A1 (en) 1999-10-29

Family

ID=27066414

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99101097A HK1016153A1 (en) 1995-10-06 1999-03-16 Butyrate prodrugs of lactic acid

Country Status (19)

Country Link
EP (1) EP0863866B1 (ko)
JP (1) JPH11512743A (ko)
KR (1) KR19990063988A (ko)
CN (1) CN1201447A (ko)
AT (1) ATE200893T1 (ko)
AU (1) AU718983B2 (ko)
BR (1) BR9610850A (ko)
CA (1) CA2233606A1 (ko)
DE (1) DE69612671T2 (ko)
DK (1) DK0863866T3 (ko)
ES (1) ES2158351T3 (ko)
GR (1) GR3035899T3 (ko)
HK (1) HK1016153A1 (ko)
IN (1) IN181999B (ko)
NZ (1) NZ319877A (ko)
PT (1) PT863866E (ko)
RU (1) RU2175967C2 (ko)
TW (1) TW422834B (ko)
WO (1) WO1997012855A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880152A (en) * 1995-10-06 1999-03-09 Vertex Pharmaceuticals, Inc. Butyrate prodrugs derived from lactic acid
US6225350B1 (en) 1998-03-10 2001-05-01 Vertex Pharmaceuticals, Inc. Butyrate prodrugs derived from lactic acid
US6878361B2 (en) 2001-07-10 2005-04-12 Battelle Memorial Institute Production of stable aqueous dispersions of carbon nanotubes
US6896864B2 (en) 2001-07-10 2005-05-24 Battelle Memorial Institute Spatial localization of dispersed single walled carbon nanotubes into useful structures
EP1449535B1 (en) * 2003-02-18 2006-05-03 Clinique La Prairie Research SA Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components
WO2005011696A1 (en) * 2003-08-01 2005-02-10 Fibrogen, Inc. Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE277700C (ko) *
DE824041C (de) * 1945-10-22 1951-12-10 Howards & Sons Ltd Verfahren zur Herstellung von aliphatischen a -Acyloxymonocarbonsaeuren
GB603189A (en) * 1945-10-22 1948-06-10 Howards & Sons Ltd Manufacture of acyloxy-carboxylic acids
US2464992A (en) * 1946-10-10 1949-03-22 Chessie E Rehberg Esters of acyloxycarboxylic acids
FR1578064A (ko) * 1968-05-20 1969-08-14
NL9200481A (nl) * 1992-03-13 1993-10-01 Univ Groningen Farmaceutisch preparaat met plaatsgerichte afgifte.
JPH08113795A (ja) * 1994-10-14 1996-05-07 T Hasegawa Co Ltd 香料組成物

Also Published As

Publication number Publication date
CA2233606A1 (en) 1997-04-10
BR9610850A (pt) 1999-07-13
KR19990063988A (ko) 1999-07-26
TW422834B (en) 2001-02-21
RU2175967C2 (ru) 2001-11-20
PT863866E (pt) 2001-09-28
JPH11512743A (ja) 1999-11-02
IN181999B (ko) 1998-11-28
DK0863866T3 (da) 2001-06-11
CN1201447A (zh) 1998-12-09
ES2158351T3 (es) 2001-09-01
ATE200893T1 (de) 2001-05-15
DE69612671T2 (de) 2004-08-05
EP0863866A1 (en) 1998-09-16
WO1997012855A1 (en) 1997-04-10
DE69612671D1 (de) 2001-06-07
GR3035899T3 (en) 2001-08-31
EP0863866B1 (en) 2001-05-02
AU718983B2 (en) 2000-05-04
NZ319877A (en) 1999-09-29
AU7249896A (en) 1997-04-28

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070930