HK1006022A1 - Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers - Google Patents

Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers

Info

Publication number
HK1006022A1
HK1006022A1 HK98105211A HK98105211A HK1006022A1 HK 1006022 A1 HK1006022 A1 HK 1006022A1 HK 98105211 A HK98105211 A HK 98105211A HK 98105211 A HK98105211 A HK 98105211A HK 1006022 A1 HK1006022 A1 HK 1006022A1
Authority
HK
Hong Kong
Prior art keywords
ribofuranosyl
deoxy
difluoro
separating
anomers
Prior art date
Application number
HK98105211A
Other languages
English (en)
Inventor
Ta-Sen Chou
Timothy James Mccarthy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1006022A1 publication Critical patent/HK1006022A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK98105211A 1992-06-22 1998-06-12 Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers HK1006022A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,303 US5256797A (en) 1992-06-22 1992-06-22 Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

Publications (1)

Publication Number Publication Date
HK1006022A1 true HK1006022A1 (en) 1999-02-05

Family

ID=25415647

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105211A HK1006022A1 (en) 1992-06-22 1998-06-12 Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers

Country Status (17)

Country Link
US (1) US5256797A (pt)
EP (1) EP0576232B1 (pt)
JP (1) JPH0656867A (pt)
KR (1) KR100302087B1 (pt)
AT (1) ATE149505T1 (pt)
BR (1) BR9302426A (pt)
CA (1) CA2098888C (pt)
CY (1) CY2091B1 (pt)
DE (1) DE69308391T2 (pt)
DK (1) DK0576232T3 (pt)
ES (1) ES2100462T3 (pt)
GR (1) GR3023060T3 (pt)
HK (1) HK1006022A1 (pt)
HU (1) HU217976B (pt)
IL (1) IL106074A (pt)
MX (1) MX9303714A (pt)
TW (1) TW233300B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9302427A (pt) * 1992-06-22 1994-01-11 Lilly Co Eli Processo estereo seletivo para a preparacao de um derivado de riboturanosila
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1294735A2 (en) 2000-05-26 2003-03-26 Novirio Pharmaceuticals Limited Methods and compositions for treating flaviviruses and pestiviruses
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
MXPA04012802A (es) 2002-06-28 2005-04-19 Idenix Cayman Ltd Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
WO2004052899A2 (en) 2002-12-12 2004-06-24 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
RU2007102281A (ru) * 2004-06-23 2008-07-27 Айденикс (Кайман) Лимитед (Ky) 5-аза-7-деазапуриновые производные для лечения заболеваний, связанных с flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP2009526782A (ja) * 2006-02-07 2009-07-23 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
GB0812895D0 (en) 2008-07-15 2008-08-20 Glycom As Crystalline carbohydrate derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ES2176279T3 (es) * 1987-08-28 2002-12-01 Lilly Co Eli Procedimiento estereoselectivo para preparar 2`-2`-difluorolactonen protegidos.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
CA2098888A1 (en) 1993-12-23
CY2091B1 (en) 2002-04-05
ES2100462T3 (es) 1997-06-16
US5256797A (en) 1993-10-26
JPH0656867A (ja) 1994-03-01
HU9301826D0 (en) 1993-09-28
ATE149505T1 (de) 1997-03-15
IL106074A (en) 1998-02-22
GR3023060T3 (en) 1997-07-30
DE69308391D1 (de) 1997-04-10
HUT64551A (en) 1994-01-28
BR9302426A (pt) 1994-01-11
HU217976B (hu) 2000-05-28
KR100302087B1 (ko) 2001-10-22
MX9303714A (es) 1994-01-31
DK0576232T3 (da) 1997-07-21
DE69308391T2 (de) 1997-07-17
CA2098888C (en) 2003-07-29
IL106074A0 (en) 1993-10-20
KR940000473A (ko) 1994-01-03
EP0576232A1 (en) 1993-12-29
EP0576232B1 (en) 1997-03-05
TW233300B (pt) 1994-11-01

Similar Documents

Publication Publication Date Title
HK1006022A1 (en) Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers
HU9302452D0 (en) Method for anomerizating nucleosides
ES2107624T3 (es) Procedimiento de glucosilacion estereoselectivo.
TW233299B (pt)
EP0183505A3 (en) Preparing 7-halo-7-deoxylincomycins
FI874903A (fi) Riktning av glasskivor speciellt foer utbuktning av dem.
UA5971A1 (uk) Спосіб отримання похідного [3н]-імідазо-[5,1-а]-1,2,3,5-тетразін-4-она
DE68906311D1 (de) Verfahren zum vakuumentgasen und vakuumentkohlen bei temperaturausgleich.
JPS565497A (en) Novel manufacture of 5**deoxyy55fluorouridine
KR880007381A (ko) 판 유리의 국부가열 장치
GR3006789T3 (pt)
EG15877A (en) Glass sheet tempering utilizing high density gas quenching
GB2225001A (en) Process for nitrogen oxices reduction with minimization of the production of other pollutants
DE3264621D1 (en) Vincamine cyclamate, process for its preparation and medicaments containing it
DE3568420D1 (en) Process for the pretreatment of 1,2-dichloroethane before its pyrolysis
ATE94158T1 (de) Ofen und glasstreckverfahren.

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120621