GT201000015A - Sulfonamidas como moduladores de trpms - Google Patents

Sulfonamidas como moduladores de trpms

Info

Publication number
GT201000015A
GT201000015A GT201000015A GT201000015A GT201000015A GT 201000015 A GT201000015 A GT 201000015A GT 201000015 A GT201000015 A GT 201000015A GT 201000015 A GT201000015 A GT 201000015A GT 201000015 A GT201000015 A GT 201000015A
Authority
GT
Guatemala
Prior art keywords
trpms
sulfonamids
modulators
compounds
affections
Prior art date
Application number
GT201000015A
Other languages
English (en)
Spanish (es)
Inventor
Shawn T Branum
Ronald K Russell
Kenneth M Wells
Raymond W Colburn
Chistopher M Flores
Jay M Matthews
James J Mcnally
Laura M Reany
Ning Qin
Christopher Teleha
Scott C Youells
Mark A Youngman
Scott L Dax
Michele C Jetter
Yi Liu
Donald LUDOVICI
Mark J Macielag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39772848&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201000015(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201000015A publication Critical patent/GT201000015A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
GT201000015A 2007-07-18 2010-01-18 Sulfonamidas como moduladores de trpms GT201000015A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95045607P 2007-07-18 2007-07-18
US12/175,740 US8153682B2 (en) 2007-07-18 2008-07-18 Sulfonamides as TRPM8 modulators

Publications (1)

Publication Number Publication Date
GT201000015A true GT201000015A (es) 2012-03-12

Family

ID=39772848

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201000015A GT201000015A (es) 2007-07-18 2010-01-18 Sulfonamidas como moduladores de trpms

Country Status (27)

Country Link
US (3) US8153682B2 (fr)
EP (1) EP2183239B1 (fr)
JP (1) JP5539868B2 (fr)
KR (1) KR101538391B1 (fr)
CN (1) CN101801949B (fr)
AR (1) AR067602A1 (fr)
AU (3) AU2008275927B8 (fr)
BR (1) BRPI0815096A2 (fr)
CA (1) CA2693159C (fr)
CL (1) CL2008002132A1 (fr)
CO (1) CO6251375A2 (fr)
CR (1) CR11284A (fr)
EA (1) EA201070158A1 (fr)
EC (1) ECSP109921A (fr)
GT (1) GT201000015A (fr)
IL (1) IL203295A (fr)
JO (1) JO2853B1 (fr)
MX (1) MX2010000690A (fr)
MY (1) MY153971A (fr)
NI (1) NI201000013A (fr)
NZ (1) NZ582555A (fr)
PA (1) PA8790401A1 (fr)
TW (1) TWI446909B (fr)
UA (1) UA99624C2 (fr)
UY (1) UY31239A1 (fr)
WO (1) WO2009012430A1 (fr)
ZA (1) ZA201001157B (fr)

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WO2010118063A2 (fr) 2009-04-06 2010-10-14 Agios Pharmaceuticals, Inc. Compositions thérapeutiques et procédés d'utilisation associés
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US20120122710A1 (en) * 2009-07-01 2012-05-17 Josep Castells Boliart Libraries of n-substituted-n-phenylethylsulfonamides for the identification of biological and pharmacological activity
RU2554870C2 (ru) 2009-10-30 2015-06-27 Янссен Фармацевтика Нв Феноксизамещенные пиримидины для использования в качестве модуляторов опиоидных рецепторов
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US8906384B2 (en) * 2010-12-22 2014-12-09 The United States Of America As Represented By The Secretary Of Agriculture Antiviral activity of bovine type III interferon against foot-and-mouth disease virus
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
EP2481727A1 (fr) 2011-01-28 2012-08-01 Dompe S.p.A. Antagonistes du récepteur TRPM8
WO2012120398A1 (fr) 2011-03-04 2012-09-13 Pfizer Limited Dérivés de carboxamide substitués par aryle en tant que modulateurs de trpm8
JP5684401B2 (ja) 2011-03-16 2015-03-11 田辺三菱製薬株式会社 Ｔｒｐｍ８遮断効果を有するスルホンアミド化合物
ES2675903T3 (es) 2011-05-03 2018-07-13 Agios Pharmaceuticals, Inc. Activadores de piruvato quinasa para uso en terapia
WO2012151440A1 (fr) 2011-05-03 2012-11-08 Agios Pharmaceuticals, Inc. Procédés d'utilisation d'activateurs de pyruvate kinase
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US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
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US9917260B2 (en) * 2013-08-23 2018-03-13 Basf Se Compounds with terminal heteroarylcyanovinylene groups and their use in organic solar cells
EA034525B1 (ru) 2014-06-23 2020-02-17 Домпе Фармачеутичи С.П.А. Производные 2-арил-4-гидрокси-1,3-тиазола для применения в качестве ингибиторов trpm8 в лечении невралгии, болей, хронической обструктивной болезни лёгких и астмы
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CN107709301B (zh) * 2015-06-23 2021-06-22 橘生药品工业株式会社 吡唑衍生物或其药理学上可接受的盐
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JP2022530936A (ja) * 2019-04-30 2022-07-05 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド ベンゾチオフェン化合物、その調製方法およびその使用
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WO2007017092A1 (fr) * 2005-08-04 2007-02-15 Bayer Healthcare Ag Derives amides d'acide 4-benzyloxy-benzoique substitue
WO2007017094A1 (fr) 2005-08-04 2007-02-15 Bayer Healthcare Ag Dérivés benzyloxyphénylméthylcarbamate substitués
WO2007134107A2 (fr) * 2006-05-10 2007-11-22 Janssen Pharmaceutica N.V. Antagonistes du récepteur 1 au froid activé par le menthol

Also Published As

Publication number Publication date
UA99624C2 (uk) 2012-09-10
CO6251375A2 (es) 2011-02-21
AU2014203797A1 (en) 2014-07-31
ECSP109921A (es) 2010-02-26
US8153682B2 (en) 2012-04-10
US20140315899A1 (en) 2014-10-23
US8809327B2 (en) 2014-08-19
JP5539868B2 (ja) 2014-07-02
US9434711B2 (en) 2016-09-06
JP2010533734A (ja) 2010-10-28
TW200918045A (en) 2009-05-01
CN101801949A (zh) 2010-08-11
KR101538391B1 (ko) 2015-07-21
US20120190674A1 (en) 2012-07-26
EA201070158A1 (ru) 2010-08-30
WO2009012430A1 (fr) 2009-01-22
CA2693159A1 (fr) 2009-01-22
CN101801949B (zh) 2014-09-24
ZA201001157B (en) 2011-04-28
IL203295A (en) 2015-09-24
BRPI0815096A2 (pt) 2015-07-14
NZ582555A (en) 2012-06-29
KR20100049598A (ko) 2010-05-12
AU2008275927B8 (en) 2014-08-14
EP2183239B1 (fr) 2012-08-22
TWI446909B (zh) 2014-08-01
AU2008275927A1 (en) 2009-01-22
EP2183239A1 (fr) 2010-05-12
MY153971A (en) 2015-04-30
PA8790401A1 (es) 2009-03-31
UY31239A1 (es) 2009-03-31
AU2016204436A1 (en) 2016-07-21
JO2853B1 (en) 2015-03-15
CA2693159C (fr) 2016-05-24
NI201000013A (es) 2010-07-22
MX2010000690A (es) 2010-06-25
AU2008275927B2 (en) 2014-08-07
CR11284A (es) 2010-08-18
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US20090264474A1 (en) 2009-10-22

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