GT200800203A - Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6 - Google Patents
Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6Info
- Publication number
- GT200800203A GT200800203A GT200800203A GT200800203A GT200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A
- Authority
- GT
- Guatemala
- Prior art keywords
- hydroxitriptamine
- heterociclilindazol
- ligandos
- sulfonil
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LA FÓRMULA GENERAL I EN LA QUE R,R1,R2,R3,R4,R5,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS ACTÚAN COMO LIGANDOS DE LOS RECEPTORES DE 5-HIDROXITRIPTAMINA (5-HT) POR LO QUE SON DE UTILIDAD EN CUADROS DE ALZHEIMER Y PARA EL MEJORAMIENTO DE LA COGNICIÓN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78953606P | 2006-04-05 | 2006-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200800203A true GT200800203A (es) | 2008-12-04 |
Family
ID=38283536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200800203A GT200800203A (es) | 2006-04-05 | 2008-10-02 | Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6 |
Country Status (17)
Country | Link |
---|---|
US (2) | US7482461B2 (es) |
EP (1) | EP2001865A1 (es) |
JP (1) | JP2009532471A (es) |
KR (1) | KR20090006148A (es) |
CN (1) | CN101432274A (es) |
AU (1) | AU2007235499A1 (es) |
BR (1) | BRPI0709718A2 (es) |
CA (1) | CA2648055A1 (es) |
CR (1) | CR10339A (es) |
EC (1) | ECSP088789A (es) |
GT (1) | GT200800203A (es) |
IL (1) | IL194365A0 (es) |
MX (1) | MX2008012824A (es) |
NO (1) | NO20084206L (es) |
RU (1) | RU2008139078A (es) |
WO (1) | WO2007117413A1 (es) |
ZA (1) | ZA200808462B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113527400A (zh) * | 2013-04-17 | 2021-10-22 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
EP3845539B1 (en) * | 2019-12-31 | 2022-11-16 | Korea Institute of Science and Technology | Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3539573A (en) * | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
US4670447A (en) * | 1983-08-22 | 1987-06-02 | Hoechst-Roussel Pharmaceuticals Inc. | Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
GB9523250D0 (en) | 1995-11-14 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
GB9523583D0 (en) | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
AR008245A1 (es) | 1996-06-21 | 1999-12-29 | Glaxo Group Ltd | Derivados de acido acetico, uso de los mismos en la fabricacion de un agente terapeutico y proceso para preparar dichos derivados |
ID23921A (id) | 1997-11-04 | 2000-05-25 | Pfizer Prod Inc | Penggantian indazola bioisostere katekol pada senyawa-senyawa aktif untuk terapi |
NZ525592A (en) | 2000-11-02 | 2004-07-30 | Wyeth Corp | 1-Aryl- or 1-alkylsufonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
EP1339708A2 (en) | 2000-11-20 | 2003-09-03 | Scios Inc. | Indole-type inhibitors of p38 kinase |
ES2264994T3 (es) | 2000-12-22 | 2007-02-01 | Wyeth | Compuestos heterociclilalquilindol o -azaindol como ligandos de 5-hidroxitriptamina-6. |
IL156517A0 (en) | 2000-12-22 | 2004-01-04 | Wyeth Corp | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
MXPA03009476A (es) | 2001-04-20 | 2004-02-12 | Wyeth Corp | Derivados de heterocicliloxi-,-tioxi-y-aminobenzazol como ligandos de 5-hidroxitriptamina-6. |
MXPA03009490A (es) | 2001-04-20 | 2004-02-12 | Wyeth Corp | Derivados de heterociclilalcoxi-,-alquiltio-y- alquilaminobenzazol como ligando de 5-hidroxitriptamina-6. |
EP1403255A4 (en) | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
WO2003013510A1 (en) | 2001-08-07 | 2003-02-20 | Smithkline Beecham P.L.C. | 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders |
US20050113283A1 (en) | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
WO2003080608A2 (en) | 2002-03-27 | 2003-10-02 | Glaxo Group Limited | Quinoline and aza-indole derivatives and their use as 5-ht6 ligands |
US7452888B2 (en) | 2002-03-27 | 2008-11-18 | Glaxo Group Limited | Quinoline derivatives and their use as 5-ht6 ligands |
TW200400177A (en) | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
US7943639B2 (en) | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
TW200401641A (en) | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
WO2004069828A1 (ja) | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
TW200418830A (en) | 2003-02-14 | 2004-10-01 | Wyeth Corp | Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
PL378120A1 (pl) | 2003-02-14 | 2006-03-06 | Wyeth | Heterocyklilo-3-sulfonyloindazole jako ligandy 5-hydroksytryptaminy |
GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
EP1676841A1 (en) * | 2004-12-30 | 2006-07-05 | Esteve Laboratorios Dr. Esteve S.A. | Substitited indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds, their prepartion and use in medicaments |
-
2007
- 2007-03-30 CN CNA2007800157190A patent/CN101432274A/zh active Pending
- 2007-03-30 BR BRPI0709718-2A patent/BRPI0709718A2/pt not_active Application Discontinuation
- 2007-03-30 EP EP07754717A patent/EP2001865A1/en not_active Withdrawn
- 2007-03-30 JP JP2009504257A patent/JP2009532471A/ja not_active Withdrawn
- 2007-03-30 MX MX2008012824A patent/MX2008012824A/es unknown
- 2007-03-30 KR KR1020087026662A patent/KR20090006148A/ko not_active Application Discontinuation
- 2007-03-30 RU RU2008139078/04A patent/RU2008139078A/ru not_active Application Discontinuation
- 2007-03-30 WO PCT/US2007/008234 patent/WO2007117413A1/en active Application Filing
- 2007-03-30 AU AU2007235499A patent/AU2007235499A1/en not_active Abandoned
- 2007-03-30 CA CA002648055A patent/CA2648055A1/en not_active Abandoned
- 2007-04-04 US US11/732,623 patent/US7482461B2/en not_active Expired - Fee Related
-
2008
- 2008-09-25 IL IL194365A patent/IL194365A0/en unknown
- 2008-10-02 GT GT200800203A patent/GT200800203A/es unknown
- 2008-10-03 CR CR10339A patent/CR10339A/es not_active Application Discontinuation
- 2008-10-03 ZA ZA200808462A patent/ZA200808462B/xx unknown
- 2008-10-03 EC EC2008008789A patent/ECSP088789A/es unknown
- 2008-10-08 NO NO20084206A patent/NO20084206L/no not_active Application Discontinuation
- 2008-12-09 US US12/330,781 patent/US20090105303A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2008139078A (ru) | 2010-05-10 |
ZA200808462B (en) | 2010-01-27 |
CA2648055A1 (en) | 2007-10-18 |
IL194365A0 (en) | 2009-08-03 |
WO2007117413A1 (en) | 2007-10-18 |
CN101432274A (zh) | 2009-05-13 |
NO20084206L (no) | 2008-10-29 |
US20090105303A1 (en) | 2009-04-23 |
BRPI0709718A2 (pt) | 2011-03-29 |
US20070238724A1 (en) | 2007-10-11 |
US7482461B2 (en) | 2009-01-27 |
KR20090006148A (ko) | 2009-01-14 |
CR10339A (es) | 2008-11-18 |
ECSP088789A (es) | 2008-11-27 |
MX2008012824A (es) | 2008-10-15 |
EP2001865A1 (en) | 2008-12-17 |
AU2007235499A1 (en) | 2007-10-18 |
JP2009532471A (ja) | 2009-09-10 |
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