GR930100500A - Phenilacetic acid derivatives, process for the preparation thereof and corresponding use. - Google Patents

Phenilacetic acid derivatives, process for the preparation thereof and corresponding use.

Info

Publication number
GR930100500A
GR930100500A GR930100500A GR930100500A GR930100500A GR 930100500 A GR930100500 A GR 930100500A GR 930100500 A GR930100500 A GR 930100500A GR 930100500 A GR930100500 A GR 930100500A GR 930100500 A GR930100500 A GR 930100500A
Authority
GR
Greece
Prior art keywords
preparation
acid derivatives
corresponding use
phenilacetic
derivatives
Prior art date
Application number
GR930100500A
Other languages
Greek (el)
Other versions
GR1002048B (en
Inventor
Jane Lorenzo Rafecas
Juan Jose Artus Surroca
Original Assignee
Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodesfarma Sa filed Critical Prodesfarma Sa
Publication of GR930100500A publication Critical patent/GR930100500A/en
Publication of GR1002048B publication Critical patent/GR1002048B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αναφέρεται σε παράγωγα φαινυλοξικού οξέως, μια διεργασία για την παρασκευή τους και αντίστοιχη χρήση. Αυτά τα παράγωγα αναγνωρίζονται από τον τύπο τους ΙΙΙ, όπου τα R1, R2 και R3 είναι τα ίδια ή διαφορετικά και είναι είτε ρίζες μεθυλίου, αιθυλίου ή προπυλίου; είτε τα R2 και τα R3, τα οποία προσαρτόνται όπως παρουσιάζεται με - (R2--R3)-, μαζί σχηματίζουν μία ρίζα -(CH2)n- όπου το n= 4ή 5 ; η διεργασία περιλαμβάνει την αντίδραση ενός άλατος δικλοφενάκ με τον αντίστοιχο αλοξικό αλκυλεστέρα του τύπου X-CH2-COO-CR1R2R3, (X=Cl ή Br) σε ένα ομοιογενές μέσο. Αυτά χρησιμοποιούνται για την παρασκευή ωThe invention relates to phenylacetic acid derivatives, a process for their preparation and corresponding use. These derivatives are recognized by formula III, wherein R1, R2 and R3 are the same or different and are either methyl, ethyl or propyl radicals; or R2 and R3, which attach as shown by - (R2 - R3) -, together form a radical - (CH2) n- where n = 4 or 5; The process comprises reacting a diclofenac salt with the corresponding alkyl aloxate of formula X-CH2-COO-CR1R2R3, (X = Cl or Br) in a homogeneous medium. These are used to make oh

GR930100500A 1992-12-14 1993-12-08 Phenilacetic acid derivatives, process for the preparation thereof and corresponding use. GR1002048B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202523A ES2065242B1 (en) 1992-12-14 1992-12-14 DERIVATIVES OF PHENYLACETIC ACID, PROCEDURE FOR ITS OBTAINING AND CORRESPONDING USE.

Publications (2)

Publication Number Publication Date
GR930100500A true GR930100500A (en) 1994-08-31
GR1002048B GR1002048B (en) 1995-11-16

Family

ID=8279093

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930100500A GR1002048B (en) 1992-12-14 1993-12-08 Phenilacetic acid derivatives, process for the preparation thereof and corresponding use.

Country Status (8)

Country Link
KR (1) KR100196240B1 (en)
AU (1) AU670139B2 (en)
CA (1) CA2111169C (en)
ES (1) ES2065242B1 (en)
GR (1) GR1002048B (en)
HU (1) HUT65711A (en)
NZ (1) NZ250409A (en)
PL (2) PL174822B1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69913133T2 (en) * 1998-04-28 2004-08-26 Russinsky Ltd. METHOD FOR PRODUCING ACECLOFENAC
WO1999062865A1 (en) * 1998-06-03 1999-12-09 Jae Chul Kim Haloethyl-2-[ (2,6-dichlorophenyl) amino] phenylacetoxyacetate derivatives and their use as an intermediate to synthesize aceclofenac
WO2005073163A1 (en) * 2004-01-30 2005-08-11 J.B.Chemicals & Pharmaceuticals Ltd. A process for the preparation of [2-(2,6-dichloro anilino) phenyl] acetoxy acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811120A1 (en) * 1988-03-31 1989-10-12 Merckle Gmbh NEOPENTYL ESTER DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
ES2020145A6 (en) * 1990-05-29 1991-07-16 Prodesfarma Sa Process for obtaining esters of 2-(2,6- dichlorophenyl)amino)phenylacetoxyacetic acid
ES2020146A6 (en) * 1990-05-29 1991-07-16 Prodesfarma Sa Process for obtaining 2-[(2,6-dichlorophenyl)amino]- phenylacetoxyacetic acid

Also Published As

Publication number Publication date
PL175116B1 (en) 1998-11-30
AU5217793A (en) 1994-06-23
KR100196240B1 (en) 1999-06-15
PL301415A1 (en) 1994-06-27
AU670139B2 (en) 1996-07-04
ES2065242A1 (en) 1995-02-01
HU9303551D0 (en) 1994-04-28
HUT65711A (en) 1994-07-28
CA2111169A1 (en) 1994-06-15
KR940014301A (en) 1994-07-18
GR1002048B (en) 1995-11-16
PL174822B1 (en) 1998-09-30
ES2065242B1 (en) 1995-10-01
CA2111169C (en) 2001-05-01
NZ250409A (en) 1995-07-26

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