GR3033815T3 - Oxazolidine-2-one derivatives. - Google Patents
Oxazolidine-2-one derivatives.Info
- Publication number
- GR3033815T3 GR3033815T3 GR20000401515T GR20000401515T GR3033815T3 GR 3033815 T3 GR3033815 T3 GR 3033815T3 GR 20000401515 T GR20000401515 T GR 20000401515T GR 20000401515 T GR20000401515 T GR 20000401515T GR 3033815 T3 GR3033815 T3 GR 3033815T3
- Authority
- GR
- Greece
- Prior art keywords
- lower alkyl
- hydrogen
- nitrile
- phenyl
- coch3
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- -1 bicyclo[2.2.1]hept-2-yl Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000002825 nitriles Chemical class 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH370193 | 1993-12-13 | ||
| CH292794 | 1994-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3033815T3 true GR3033815T3 (en) | 2000-10-31 |
Family
ID=25691748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000401515T GR3033815T3 (en) | 1993-12-13 | 2000-06-29 | Oxazolidine-2-one derivatives. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5574055A (forum.php) |
| EP (1) | EP0657440B1 (forum.php) |
| JP (1) | JP2602635B2 (forum.php) |
| KR (1) | KR100362295B1 (forum.php) |
| CN (1) | CN1051308C (forum.php) |
| AT (1) | ATE191480T1 (forum.php) |
| AU (1) | AU684319B2 (forum.php) |
| CA (1) | CA2135861A1 (forum.php) |
| CZ (1) | CZ291030B6 (forum.php) |
| DE (1) | DE59409270D1 (forum.php) |
| DK (1) | DK0657440T3 (forum.php) |
| ES (1) | ES2145087T3 (forum.php) |
| GR (1) | GR3033815T3 (forum.php) |
| HU (1) | HU221809B1 (forum.php) |
| IL (1) | IL111890A (forum.php) |
| NO (1) | NO305204B1 (forum.php) |
| NZ (1) | NZ270083A (forum.php) |
| PT (1) | PT657440E (forum.php) |
| RU (1) | RU2133743C1 (forum.php) |
| TW (1) | TW286317B (forum.php) |
| UA (1) | UA44691C2 (forum.php) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
| FR2739856B1 (fr) * | 1995-10-11 | 1997-11-14 | Synthelabo | Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
| AU7135996A (en) * | 1995-10-11 | 1997-04-30 | Synthelabo | Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof |
| FR2751653B1 (fr) * | 1996-07-25 | 1998-09-04 | Synthelabo | Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
| FR2751651B1 (fr) * | 1996-07-25 | 1998-09-04 | Synthelabo | Derives de 3-(benzo[b]thien-3-yl)oxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
| DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19601265A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| DE19601627A1 (de) | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| HRP970049A2 (en) * | 1996-02-06 | 1998-04-30 | Bayer Ag | New heteroaryl oxazolidinones |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| JP3865450B2 (ja) * | 1997-02-14 | 2007-01-10 | 田辺製薬株式会社 | パーキンソニズム治療剤 |
| GB9717807D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| GB9912417D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| RU2213959C2 (ru) * | 2001-01-15 | 2003-10-10 | Войсковая часть 61469 МО РФ | Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием |
| WO2002072066A1 (en) * | 2001-02-05 | 2002-09-19 | Pharmacia & Upjohn Company | Composition for rectal delivery of an oxazolidinone antibacterial drug |
| US6686363B2 (en) | 2001-11-29 | 2004-02-03 | Kyorin Pharmaceutical Co., Ltd. | Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof |
| CA2530140C (en) | 2003-07-02 | 2010-11-09 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| WO2005028467A1 (en) * | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds |
| WO2007102082A1 (en) * | 2006-03-09 | 2007-09-13 | Glenmark Pharmaceuticals Limited | High oxazolidinone content solid dosage forms |
| CN103497173A (zh) * | 2006-03-31 | 2014-01-08 | 财团法人乙卯研究所 | 具有杂环的新化合物 |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| US8633197B2 (en) * | 2007-06-08 | 2014-01-21 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| BRPI0813331A2 (pt) * | 2007-06-08 | 2014-12-23 | Janssen Pharmaceutica Nv | Derivados de piperidina/piperazina |
| EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| CN101883768A (zh) | 2007-10-02 | 2010-11-10 | 财团法人乙卯研究所 | 具有7元杂环的噁唑烷酮衍生物 |
| EP2296659B1 (en) * | 2008-06-05 | 2016-12-21 | Janssen Pharmaceutica, N.V. | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1180089A (en) * | 1967-10-20 | 1970-02-04 | Delalande Sa | Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation |
| FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| FR2380780A2 (fr) * | 1977-02-22 | 1978-09-15 | Delalande Sa | Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs |
| LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
| CA1171865A (en) * | 1980-06-04 | 1984-07-31 | Alain Lacour | N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics |
| FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
| FI935920A0 (fi) * | 1992-04-30 | 1993-12-29 | Taiho Pharmaceutical Co Ltd | Oxazolinderivat och deras farmaceutiskt godtagbara salter |
-
1994
- 1994-11-10 TW TW083110422A patent/TW286317B/zh active
- 1994-11-15 CA CA002135861A patent/CA2135861A1/en not_active Abandoned
- 1994-12-02 US US08/349,119 patent/US5574055A/en not_active Expired - Fee Related
- 1994-12-03 DE DE59409270T patent/DE59409270D1/de not_active Expired - Fee Related
- 1994-12-03 PT PT94119100T patent/PT657440E/pt unknown
- 1994-12-03 ES ES94119100T patent/ES2145087T3/es not_active Expired - Lifetime
- 1994-12-03 DK DK94119100T patent/DK0657440T3/da active
- 1994-12-03 AT AT94119100T patent/ATE191480T1/de not_active IP Right Cessation
- 1994-12-03 EP EP94119100A patent/EP0657440B1/de not_active Expired - Lifetime
- 1994-12-06 IL IL11189094A patent/IL111890A/en not_active IP Right Cessation
- 1994-12-06 AU AU80233/94A patent/AU684319B2/en not_active Ceased
- 1994-12-07 NZ NZ270083A patent/NZ270083A/en unknown
- 1994-12-07 HU HU9403494A patent/HU221809B1/hu not_active IP Right Cessation
- 1994-12-09 CN CN94112939A patent/CN1051308C/zh not_active Expired - Fee Related
- 1994-12-12 CZ CZ19943126A patent/CZ291030B6/cs not_active IP Right Cessation
- 1994-12-12 JP JP6307692A patent/JP2602635B2/ja not_active Expired - Fee Related
- 1994-12-12 UA UA94129171A patent/UA44691C2/uk unknown
- 1994-12-12 KR KR1019940033670A patent/KR100362295B1/ko not_active Expired - Fee Related
- 1994-12-12 NO NO944802A patent/NO305204B1/no not_active IP Right Cessation
- 1994-12-13 RU RU94043806A patent/RU2133743C1/ru not_active IP Right Cessation
-
2000
- 2000-06-29 GR GR20000401515T patent/GR3033815T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO944802D0 (no) | 1994-12-12 |
| DK0657440T3 (da) | 2000-09-04 |
| ATE191480T1 (de) | 2000-04-15 |
| EP0657440B1 (de) | 2000-04-05 |
| NZ270083A (en) | 1996-02-27 |
| JP2602635B2 (ja) | 1997-04-23 |
| CZ312694A3 (en) | 1995-08-16 |
| NO944802L (no) | 1995-06-14 |
| AU8023394A (en) | 1995-06-22 |
| CN1051308C (zh) | 2000-04-12 |
| ES2145087T3 (es) | 2000-07-01 |
| RU2133743C1 (ru) | 1999-07-27 |
| AU684319B2 (en) | 1997-12-11 |
| KR100362295B1 (ko) | 2003-03-03 |
| HU9403494D0 (en) | 1995-02-28 |
| CZ291030B6 (cs) | 2002-12-11 |
| KR950017993A (ko) | 1995-07-22 |
| DE59409270D1 (de) | 2000-05-11 |
| PT657440E (pt) | 2000-09-29 |
| HU221809B1 (hu) | 2003-01-28 |
| HUT72315A (en) | 1996-04-29 |
| NO305204B1 (no) | 1999-04-19 |
| RU94043806A (ru) | 1996-10-27 |
| UA44691C2 (uk) | 2002-03-15 |
| CA2135861A1 (en) | 1995-06-14 |
| IL111890A0 (en) | 1995-03-15 |
| EP0657440A1 (de) | 1995-06-14 |
| CN1109054A (zh) | 1995-09-27 |
| TW286317B (forum.php) | 1996-09-21 |
| JPH07196634A (ja) | 1995-08-01 |
| IL111890A (en) | 1998-12-06 |
| US5574055A (en) | 1996-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |