PT92591A - Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem

Info

Publication number
PT92591A
PT92591A PT92591A PT9259189A PT92591A PT 92591 A PT92591 A PT 92591A PT 92591 A PT92591 A PT 92591A PT 9259189 A PT9259189 A PT 9259189A PT 92591 A PT92591 A PT 92591A
Authority
PT
Portugal
Prior art keywords
carbon atoms
phenyl
loweralkyl
straight
hydrogen
Prior art date
Application number
PT92591A
Other languages
English (en)
Other versions
PT92591B (pt
Inventor
Ghanshyam Patil
Khuong H X Mai
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PT92591A publication Critical patent/PT92591A/pt
Publication of PT92591B publication Critical patent/PT92591B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/12—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Processing Of Solid Wastes (AREA)
PT92591A 1988-12-15 1989-12-15 Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem PT92591B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,008 US4935422A (en) 1988-12-15 1988-12-15 Acyloxypropanolamines

Publications (2)

Publication Number Publication Date
PT92591A true PT92591A (pt) 1990-06-29
PT92591B PT92591B (pt) 1995-09-12

Family

ID=23092348

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92591A PT92591B (pt) 1988-12-15 1989-12-15 Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem

Country Status (17)

Country Link
US (1) US4935422A (pt)
EP (1) EP0373593B1 (pt)
JP (1) JPH02258750A (pt)
AT (1) ATE108765T1 (pt)
AU (1) AU639672B2 (pt)
CA (1) CA2005372A1 (pt)
DE (1) DE68916920T2 (pt)
DK (1) DK634589A (pt)
FI (1) FI895979A7 (pt)
HU (1) HU204025B (pt)
IL (1) IL92651A0 (pt)
MY (1) MY129948A (pt)
NO (1) NO895043L (pt)
NZ (1) NZ231753A (pt)
PT (1) PT92591B (pt)
RU (1) RU1776257C (pt)
ZA (1) ZA899621B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US7074828B2 (en) * 2002-12-05 2006-07-11 The Governors Of The University Of Alberta Compounds that stimulate glucose utilization and methods of use
US7084173B2 (en) * 2001-03-30 2006-08-01 The Governors Of The Univerity Of Alberta Compounds that stimulate glucose utilization and methods of use
AU2003220222A1 (en) 2002-03-13 2003-09-29 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US7524885B2 (en) * 2002-04-01 2009-04-28 The Governors Of The University Of Alberta Compounds that stimulate glucose utilization and methods of use
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
EP1843734A4 (en) * 2005-02-03 2008-09-10 Signum Biosciences Inc COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION
US9486441B2 (en) 2008-04-21 2016-11-08 Signum Biosciences, Inc. Compounds, compositions and methods for making the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058768B (en) * 1979-09-10 1983-07-20 Union Carbide Corp 2-hydroxy-3-t-butylamino-1-propyl methacrylate useful as a wetadhesion aid
ZA827646B (en) * 1981-11-12 1983-08-31 American Hospital Supply Corp Esters of aryloxypropanolamine derivatives
US4692446A (en) * 1981-11-12 1987-09-08 E. I. Du Pont De Nemours & Co., Inc. Esters of aryloxypropanolamine derivatives and medicinal uses
US4582855A (en) * 1981-11-12 1986-04-15 American Hospital Supply Corporation Aromatic and esters of hydroxypropylamines
US4897417A (en) * 1988-12-15 1990-01-30 E. I. Du Pont De Nemours & Co. Prodrugs of 3,4-hydroxy benzoyloxypropanolamines
US4959390A (en) * 1988-12-15 1990-09-25 E. I. Du Pont De Nemours And Company Polyhydroxybenzyloxypropanolamines
US4966914A (en) * 1988-12-15 1990-10-30 E. I. Du Pont De Nemours And Company Oculoselective beta-blockers as antiglaucoma agents

Also Published As

Publication number Publication date
ATE108765T1 (de) 1994-08-15
FI895979A7 (fi) 1990-06-16
DK634589A (da) 1990-06-16
EP0373593B1 (en) 1994-07-20
RU1776257C (ru) 1992-11-15
AU639672B2 (en) 1993-08-05
IL92651A0 (en) 1990-08-31
DE68916920T2 (de) 1994-12-01
NO895043D0 (no) 1989-12-14
US4935422A (en) 1990-06-19
DK634589D0 (da) 1989-12-14
PT92591B (pt) 1995-09-12
NO895043L (no) 1990-06-18
HU204025B (en) 1991-11-28
ZA899621B (en) 1991-08-28
DE68916920D1 (de) 1994-08-25
HUT53592A (en) 1990-11-28
NZ231753A (en) 1991-07-26
HU896638D0 (en) 1990-02-28
JPH02258750A (ja) 1990-10-19
CA2005372A1 (en) 1990-06-15
FI895979A0 (fi) 1989-12-14
MY129948A (en) 2007-05-31
EP0373593A3 (en) 1991-03-20
AU4679789A (en) 1990-06-21
EP0373593A2 (en) 1990-06-20

Similar Documents

Publication Publication Date Title
NO175479C (no) Analogifremgangsmåte ved fremstilling av 1-aza-tricyklo-(7,2,0,0.3,8)undec-2-en-2-karboksylat-derivater
DE69331843D1 (de) Xanthine-Derivate als Antidepressiva
PT97993A (pt) Processo para a preparacao de derivados de amidas ciclicas e de composicoes farmaceuticas que os contem
BR9502085A (pt) Derivado de 11,21-bis-fenil-19-norpregnano,processo de preparação do mesmo e composição farmaceutica
NO931317D0 (no) Et terapeutisk middel for parkinson's sykdom
PT92591A (pt) Processo para a preparacao de aciloxipropanolaminas com accao bloqueadora beta--adrenergica e de composicoes farmaceuticas que as contem
BR9812239A (pt) Composto, formulação farmacêutica, uso do composto, processos para o tratamento de distúrbios, para o tratamento de distúrbios mediados por 5-hidroxitriptamina, e, para a preparação do composto
DK384485A (da) 1,6-naphthyridinderivater med kardilaterende virkning
MX25858A (es) 3-[1-tiazolidinilbutil-4-piperazinil]-1h-indazolesun procedimiento para su preparacion y su uso comomedicamentos.
ES8504159A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,2,5,-tidiazol.
PT92589A (pt) Processo para a preparacao de profarmacos de 3,4-hidroxi-benzoiloxipropanolaminas com accao beta-bloqueadora oculo-selectiva e de composicoes farmaceuticas que os contem
PT92590A (pt) Processo para a preparacao de profarmacos e farmacos beta-bloqueadores oculo-selectivos com grupos ester e de composicoes farmaceuticas que os contem
MX9302889A (es) Benzo(b)tiofen-3-il-piperazinas, un procedimiento para su preparacion y su uso como medicamentos.
EP0373591A3 (en) Polyhydroxybenzyloxypropanolamines
NO976101D0 (no) Nye ellipticinforbindelser, en fremgangsmåte ved deres fremstilling, samt farmasöytiske blandinger som inneholder dem

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19950505

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19961130