ES8203084A1 - Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) - Google Patents

Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)

Info

Publication number
ES8203084A1
ES8203084A1 ES501423A ES501423A ES8203084A1 ES 8203084 A1 ES8203084 A1 ES 8203084A1 ES 501423 A ES501423 A ES 501423A ES 501423 A ES501423 A ES 501423A ES 8203084 A1 ES8203084 A1 ES 8203084A1
Authority
ES
Spain
Prior art keywords
hydrogen
loweralkyl
chem
isobenzofuran
cyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501423A
Other languages
English (en)
Other versions
ES501423A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES501423A0 publication Critical patent/ES501423A0/es
Publication of ES8203084A1 publication Critical patent/ES8203084A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESPIRO(CICLOHEXANO-1,1''(3''H)-ISOBENXOFURANOS), DE SUS ISOMEROS GEOMETRICOS Y ANTIPODAS OPTICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO Y R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE BENZANILIDA CON EL COMPUESTO DE FORMULA (II), EN LA QUE R5 Y R6 CON ALCOHILO INFERIOR, CON LO QUE SE OBTIENE UNA MEZCLA DE LOS ISOMEROS CIS Y TRANS DE LA ISOBENZOFURAN-3-ONA, DE FORMULA (III), EN LA QUE R5 Y R6 TIENEN EL SIGNIFICADO ANTERIORMENTE INDICADO. LA CONDENSACION SE LLEVA A CABO FORMANDO EL DERIVADO DE DI-LITIO DE BENZAINLIDA Y COPULANDOLO CON LA CICLOHEXANONA EN PRESENCIA DE UN ACIDO.
ES501423A 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) Expired ES8203084A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/073,055 US4263317A (en) 1979-09-06 1979-09-06 Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s

Publications (2)

Publication Number Publication Date
ES501423A0 ES501423A0 (es) 1982-02-16
ES8203084A1 true ES8203084A1 (es) 1982-02-16

Family

ID=22111440

Family Applications (8)

Application Number Title Priority Date Filing Date
ES494690A Expired ES8106512A1 (es) 1979-09-06 1980-09-01 Un procedimiento para la preparacion de espiro (ciclohexano-1.1'(3'h)-isobenzofuranos)
ES501420A Expired ES8203082A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501421A Expired ES8203083A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501423A Expired ES8203084A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501424A Granted ES501424A0 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501419A Expired ES8203872A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzoeuranos)
ES501422A Granted ES501422A0 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro(ciclohexano- 1,1'(3'h)-isobenzofuranos)
ES501418A Expired ES8202809A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES494690A Expired ES8106512A1 (es) 1979-09-06 1980-09-01 Un procedimiento para la preparacion de espiro (ciclohexano-1.1'(3'h)-isobenzofuranos)
ES501420A Expired ES8203082A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501421A Expired ES8203083A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES501424A Granted ES501424A0 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)
ES501419A Expired ES8203872A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzoeuranos)
ES501422A Granted ES501422A0 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro(ciclohexano- 1,1'(3'h)-isobenzofuranos)
ES501418A Expired ES8202809A1 (es) 1979-09-06 1981-04-15 Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos)

Country Status (4)

Country Link
US (1) US4263317A (es)
EP (1) EP0027522A1 (es)
JP (1) JPS5645469A (es)
ES (8) ES8106512A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301292A (en) * 1979-09-06 1981-11-17 Hoechst-Roussel Pharmaceuticals, Incorporated 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
US4288623A (en) * 1979-09-06 1981-09-08 Hoechst-Roussel Pharmaceuticals Inc. 1-Aryl-4-amino-cyclohexan-1-ols
US4313959A (en) * 1981-04-27 1982-02-02 Hoechst-Roussel Pharmaceuticals Inc. (Arylmethyl)phenyl-aminocyclohexanols, cyclohexenes and intermediates thereof
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4517311A (en) * 1981-10-19 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4594435A (en) * 1982-09-13 1986-06-10 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for 2'-substituted-spiro[benzofuran-2(3H),1'-cycloalkanes]
US5173499A (en) * 1988-04-15 1992-12-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US4981980A (en) * 1989-09-14 1991-01-01 Merck & Co., Inc. Drug for treating manic depression
US5239110A (en) * 1992-12-30 1993-08-24 Sterling Winthrop, Inc. Phenylcyclohexanol derivatives as agents for treating CNS disorders
DE19962866A1 (de) 1999-12-24 2001-07-05 Effem Gmbh Verfahren zum Herstellen gefüllter Nahrungsmittel-Hohlkörper
US6453106B1 (en) 2000-06-30 2002-09-17 Ge-Act Communications, Inc. Method and apparatus for a cable location and protection system
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
WO2008010765A1 (en) * 2006-07-19 2008-01-24 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US4031224A (en) * 1976-04-29 1977-06-21 American Hoechst Corporation 1,3-Dihydro-heteroarylspiro (isobenzofuran)s

Also Published As

Publication number Publication date
ES8202810A1 (es) 1982-03-01
US4263317A (en) 1981-04-21
ES501421A0 (es) 1982-02-16
ES501418A0 (es) 1982-03-01
ES501419A0 (es) 1982-04-01
ES8202809A1 (es) 1982-03-01
ES8203872A1 (es) 1982-04-01
ES8203085A1 (es) 1982-02-16
ES501420A0 (es) 1982-02-16
ES8203083A1 (es) 1982-02-16
ES501423A0 (es) 1982-02-16
ES494690A0 (es) 1981-07-16
ES501422A0 (es) 1982-03-01
ES8203082A1 (es) 1982-02-16
EP0027522A1 (en) 1981-04-29
JPS5645469A (en) 1981-04-25
ES8106512A1 (es) 1981-07-16
ES501424A0 (es) 1982-02-16

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