GR3025837T3 - Ecteinascidins 736 and 722 - Google Patents
Ecteinascidins 736 and 722Info
- Publication number
- GR3025837T3 GR3025837T3 GR980400013T GR980400013T GR3025837T3 GR 3025837 T3 GR3025837 T3 GR 3025837T3 GR 980400013 T GR980400013 T GR 980400013T GR 980400013 T GR980400013 T GR 980400013T GR 3025837 T3 GR3025837 T3 GR 3025837T3
- Authority
- GR
- Greece
- Prior art keywords
- tetrahydro
- ecteinascidins
- isoquinolines
- carboline
- lymphoma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/620,427 US5149804A (en) | 1990-11-30 | 1990-11-30 | Ecteinascidins 736 and 722 |
PCT/US1991/008988 WO1992009607A1 (en) | 1990-11-30 | 1991-11-27 | Ecteinascidins 736 and 722 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3025837T3 true GR3025837T3 (en) | 1998-04-30 |
Family
ID=24485894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR980400013T GR3025837T3 (en) | 1990-11-30 | 1998-01-07 | Ecteinascidins 736 and 722 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5149804A (el) |
EP (1) | EP0559838B1 (el) |
JP (1) | JP3098029B2 (el) |
AT (1) | ATE159022T1 (el) |
AU (1) | AU650829B2 (el) |
DE (1) | DE69127905T2 (el) |
DK (1) | DK0559838T3 (el) |
ES (1) | ES2111631T3 (el) |
GR (1) | GR3025837T3 (el) |
WO (1) | WO1992009607A1 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
DE69821629T2 (de) * | 1997-09-19 | 2005-01-13 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Kombinationen von Cytokinen mit neurotroper Aktivität |
BR9909488B1 (pt) * | 1998-04-06 | 2011-02-08 | ecteinascidinas semi-sintéticas e composição farmacêutica. | |
AU759281B2 (en) * | 1998-05-11 | 2003-04-10 | Pharma Mar S.A. | Metabolites of ecteinascidin 743 |
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
SI1280809T1 (sl) * | 2000-04-12 | 2005-12-31 | Pharma Mar Sa | Antitumorski ekteinascidin derivati |
US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
CA2428160C (en) * | 2000-11-06 | 2009-10-13 | Pharma Mar, S.A. | Compositions for antitumor treatment containing ecteinascidin 743 |
GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
CA2544320A1 (en) * | 2003-11-13 | 2005-06-02 | Pharma Mar, S.A.U. | Method of treating cancer using a combination comprising et-743 and 5-fluorouracil |
US20080255132A1 (en) * | 2003-11-14 | 2008-10-16 | Eric Rowinsky | Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer |
GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
WO2006005602A2 (en) * | 2004-07-09 | 2006-01-19 | Pharma Mar, S.A. | Use of ecteinascidin in the treatment of cancer in patients with low level of brca1 |
AU2005288696A1 (en) * | 2004-09-28 | 2006-04-06 | Pharma Mar S.A., Sociedad Unipersonal | Ecteinascidin compounds as anti -inflammatory agents |
PL1827500T3 (pl) * | 2004-10-26 | 2009-09-30 | Pharma Mar Sa | Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743 |
ES2290844T3 (es) | 2004-10-29 | 2008-02-16 | Pharma Mar S.A., Sociedad Unipersonal | Composiciones que comprenden ecteinascidinas y un disacarido. |
GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
AU2008313634A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Prognostic molecular markers for ET-743 treatment |
ES2790414T3 (es) | 2010-11-12 | 2020-10-27 | Pharma Mar Sa | Terapia de combinación con un inhibidor de topoisomerasa |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
AR121894A1 (es) | 2020-04-21 | 2022-07-20 | Pharma Mar Sa | Conjugados de anticuerpos de fármacos |
-
1990
- 1990-11-30 US US07/620,427 patent/US5149804A/en not_active Expired - Lifetime
-
1991
- 1991-11-27 DK DK92904206.7T patent/DK0559838T3/da active
- 1991-11-27 AT AT92904206T patent/ATE159022T1/de not_active IP Right Cessation
- 1991-11-27 DE DE69127905T patent/DE69127905T2/de not_active Expired - Lifetime
- 1991-11-27 JP JP04504283A patent/JP3098029B2/ja not_active Expired - Fee Related
- 1991-11-27 EP EP92904206A patent/EP0559838B1/en not_active Expired - Lifetime
- 1991-11-27 AU AU91764/91A patent/AU650829B2/en not_active Expired
- 1991-11-27 ES ES92904206T patent/ES2111631T3/es not_active Expired - Lifetime
- 1991-11-27 WO PCT/US1991/008988 patent/WO1992009607A1/en active IP Right Grant
-
1998
- 1998-01-07 GR GR980400013T patent/GR3025837T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU650829B2 (en) | 1994-06-30 |
JP3098029B2 (ja) | 2000-10-10 |
JPH06503579A (ja) | 1994-04-21 |
EP0559838A4 (en) | 1994-06-29 |
EP0559838A1 (en) | 1993-09-15 |
AU9176491A (en) | 1992-06-25 |
DE69127905T2 (de) | 1998-05-28 |
ES2111631T3 (es) | 1998-03-16 |
DK0559838T3 (da) | 1998-05-18 |
EP0559838B1 (en) | 1997-10-08 |
DE69127905D1 (de) | 1997-11-13 |
US5149804A (en) | 1992-09-22 |
WO1992009607A1 (en) | 1992-06-11 |
ATE159022T1 (de) | 1997-10-15 |
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