ES2111631T3 - Ecteinascidinas 736 y 722. - Google Patents

Ecteinascidinas 736 y 722.

Info

Publication number
ES2111631T3
ES2111631T3 ES92904206T ES92904206T ES2111631T3 ES 2111631 T3 ES2111631 T3 ES 2111631T3 ES 92904206 T ES92904206 T ES 92904206T ES 92904206 T ES92904206 T ES 92904206T ES 2111631 T3 ES2111631 T3 ES 2111631T3
Authority
ES
Spain
Prior art keywords
ecteinascidines
tunicada
isoquinoleinas
tetrahidro
caribbean
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92904206T
Other languages
English (en)
Inventor
Kenneth Rinehart
Ryuichi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois filed Critical University of Illinois
Application granted granted Critical
Publication of ES2111631T3 publication Critical patent/ES2111631T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE HAN SEPARADO LAS ECTEINASCIDINAS 722 Y 736 (LAS ET 722 Y 736) DE LA TUNICADA CARIBEÑA ECTEINASCIDIA TURBINATA Y SUS ESTRUCTURAS SE HA DESIGNADO BIS(TETRAHIDRO-ISOQUINOLEINAS) SUSTITUIDAS POR TETRAHIDRO-(BETA)-CARBOLINA EN RELACION A LAS ET 729 Y 743 YA CONOCIDAS. LAS ET 722 Y 736 PROTEGEN A LOS RATONES IN VIVO A CONCENTRACIONES MUY BAJAS CONTRA EL LINFOMA P388, LA MELANOMA B16 Y EL CARCINOMA PULMONAR DE LEWIS.
ES92904206T 1990-11-30 1991-11-27 Ecteinascidinas 736 y 722. Expired - Lifetime ES2111631T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/620,427 US5149804A (en) 1990-11-30 1990-11-30 Ecteinascidins 736 and 722

Publications (1)

Publication Number Publication Date
ES2111631T3 true ES2111631T3 (es) 1998-03-16

Family

ID=24485894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92904206T Expired - Lifetime ES2111631T3 (es) 1990-11-30 1991-11-27 Ecteinascidinas 736 y 722.

Country Status (10)

Country Link
US (1) US5149804A (es)
EP (1) EP0559838B1 (es)
JP (1) JP3098029B2 (es)
AT (1) ATE159022T1 (es)
AU (1) AU650829B2 (es)
DE (1) DE69127905T2 (es)
DK (1) DK0559838T3 (es)
ES (1) ES2111631T3 (es)
GR (1) GR3025837T3 (es)
WO (1) WO1992009607A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
CA2301693A1 (en) * 1997-09-19 1999-04-01 Klaus Unsicker Cytokines having neurotrophic activity
IL138856A0 (en) * 1998-04-06 2001-10-31 Univ Illinois Semi-synthetic ecteinascidins
US6316214B1 (en) * 1998-05-11 2001-11-13 The Board Of Trustees Of The University Of Illinois ETM-775 metabolite of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
PT1280809E (pt) * 2000-04-12 2005-11-30 Pharma Mar Sa Derivados antitumorais de ecteinascidina
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素－743在制备用于治疗肿瘤的药剂中的应用
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DE602004016376D1 (de) * 2003-11-13 2008-10-16 Pharma Mar Sau Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2005049030A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
EP1768671A2 (en) * 2004-07-09 2007-04-04 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
SI1827500T1 (sl) * 2004-10-26 2009-10-31 Pharma Mar Sa Pegiliran liposomski doksorubicin v kombinaciji s ekteinescidinom 743
DK1658848T3 (da) 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
KR20170096065A (ko) 2010-11-12 2017-08-23 파르마 마르 에스.에이. 항종양 알칼로이드를 이용한 병용요법
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN115427081A (zh) 2020-04-21 2022-12-02 法马马有限公司 药物抗体共轭物

Also Published As

Publication number Publication date
US5149804A (en) 1992-09-22
WO1992009607A1 (en) 1992-06-11
AU650829B2 (en) 1994-06-30
AU9176491A (en) 1992-06-25
JP3098029B2 (ja) 2000-10-10
DK0559838T3 (da) 1998-05-18
DE69127905D1 (de) 1997-11-13
EP0559838B1 (en) 1997-10-08
DE69127905T2 (de) 1998-05-28
ATE159022T1 (de) 1997-10-15
EP0559838A4 (en) 1994-06-29
GR3025837T3 (en) 1998-04-30
JPH06503579A (ja) 1994-04-21
EP0559838A1 (en) 1993-09-15

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