GR3023060T3 - Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers - Google Patents
Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomersInfo
- Publication number
- GR3023060T3 GR3023060T3 GR970400728T GR970400728T GR3023060T3 GR 3023060 T3 GR3023060 T3 GR 3023060T3 GR 970400728 T GR970400728 T GR 970400728T GR 970400728 T GR970400728 T GR 970400728T GR 3023060 T3 GR3023060 T3 GR 3023060T3
- Authority
- GR
- Greece
- Prior art keywords
- ribofuranosyl
- deoxy
- difluoro
- separating
- anomers
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/902,303 US5256797A (en) | 1992-06-22 | 1992-06-22 | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3023060T3 true GR3023060T3 (en) | 1997-07-30 |
Family
ID=25415647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400728T GR3023060T3 (en) | 1992-06-22 | 1997-04-08 | Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5256797A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0576232B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH0656867A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100302087B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE149505T1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9302426A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2098888C (cg-RX-API-DMAC7.html) |
| CY (1) | CY2091B1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69308391T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0576232T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2100462T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3023060T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1006022A1 (cg-RX-API-DMAC7.html) |
| HU (1) | HU217976B (cg-RX-API-DMAC7.html) |
| IL (1) | IL106074A (cg-RX-API-DMAC7.html) |
| MX (1) | MX9303714A (cg-RX-API-DMAC7.html) |
| TW (1) | TW233300B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU214030B (en) * | 1992-06-22 | 1997-12-29 | Lilly Co Eli | Process for preparing alpha-anomer enriched 1-halogen-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| JP2005533824A (ja) | 2002-06-28 | 2005-11-10 | イデニクス（ケイマン）リミテツド | フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| EP1585529A4 (en) | 2002-12-12 | 2008-05-28 | Idenix Cayman Ltd | PROCESS FOR PREPARING 2'-BRANCHED NUCLEOSIDES |
| JP2008503562A (ja) * | 2004-06-23 | 2008-02-07 | イデニクス（ケイマン）リミテツド | フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体 |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
| CA2634749C (en) | 2005-12-23 | 2014-08-19 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| WO2007092705A2 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
| GB0812895D0 (en) * | 2008-07-15 | 2008-08-20 | Glycom As | Crystalline carbohydrate derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| ES2131152T3 (es) * | 1987-08-28 | 1999-07-16 | Lilly Co Eli | Procedimiento para aislar selectivamente beta-2'-desoxi-2',2'-difluorocitidina o sus sales. |
-
1992
- 1992-06-22 US US07/902,303 patent/US5256797A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 EP EP93304821A patent/EP0576232B1/en not_active Expired - Lifetime
- 1993-06-21 JP JP5149152A patent/JPH0656867A/ja active Pending
- 1993-06-21 DE DE69308391T patent/DE69308391T2/de not_active Expired - Lifetime
- 1993-06-21 BR BR9302426A patent/BR9302426A/pt not_active Application Discontinuation
- 1993-06-21 AT AT93304821T patent/ATE149505T1/de active
- 1993-06-21 MX MX9303714A patent/MX9303714A/es unknown
- 1993-06-21 DK DK93304821.7T patent/DK0576232T3/da active
- 1993-06-21 KR KR1019930011306A patent/KR100302087B1/ko not_active Expired - Fee Related
- 1993-06-21 IL IL106074A patent/IL106074A/en not_active IP Right Cessation
- 1993-06-21 CA CA002098888A patent/CA2098888C/en not_active Expired - Lifetime
- 1993-06-21 ES ES93304821T patent/ES2100462T3/es not_active Expired - Lifetime
- 1993-06-21 HU HU9301826A patent/HU217976B/hu not_active IP Right Cessation
- 1993-06-22 TW TW082104993A patent/TW233300B/zh not_active IP Right Cessation
-
1997
- 1997-04-08 GR GR970400728T patent/GR3023060T3/el unknown
-
1998
- 1998-06-12 HK HK98105211A patent/HK1006022A1/en not_active IP Right Cessation
- 1998-06-18 CY CY9800012A patent/CY2091B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0576232T3 (da) | 1997-07-21 |
| HK1006022A1 (en) | 1999-02-05 |
| KR100302087B1 (ko) | 2001-10-22 |
| ATE149505T1 (de) | 1997-03-15 |
| DE69308391D1 (de) | 1997-04-10 |
| JPH0656867A (ja) | 1994-03-01 |
| EP0576232B1 (en) | 1997-03-05 |
| HU9301826D0 (en) | 1993-09-28 |
| ES2100462T3 (es) | 1997-06-16 |
| DE69308391T2 (de) | 1997-07-17 |
| HU217976B (hu) | 2000-05-28 |
| BR9302426A (pt) | 1994-01-11 |
| EP0576232A1 (en) | 1993-12-29 |
| IL106074A0 (en) | 1993-10-20 |
| CA2098888C (en) | 2003-07-29 |
| CA2098888A1 (en) | 1993-12-23 |
| TW233300B (cg-RX-API-DMAC7.html) | 1994-11-01 |
| US5256797A (en) | 1993-10-26 |
| CY2091B1 (en) | 2002-04-05 |
| IL106074A (en) | 1998-02-22 |
| MX9303714A (es) | 1994-01-31 |
| KR940000473A (ko) | 1994-01-03 |
| HUT64551A (en) | 1994-01-28 |
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