GR3005779T3 - - Google Patents
Info
- Publication number
- GR3005779T3 GR3005779T3 GR920402101T GR920402101T GR3005779T3 GR 3005779 T3 GR3005779 T3 GR 3005779T3 GR 920402101 T GR920402101 T GR 920402101T GR 920402101 T GR920402101 T GR 920402101T GR 3005779 T3 GR3005779 T3 GR 3005779T3
- Authority
- GR
- Greece
- Prior art keywords
- group
- erythemathodes
- immunomodulator
- prophylaxis
- chem
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002462 imidazolines Chemical class 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 201000003068 rheumatic fever Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63253391A JPH02101065A (ja) | 1988-10-06 | 1988-10-06 | イミダゾリン誘導体及びその製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3005779T3 true GR3005779T3 (enExample) | 1993-06-07 |
Family
ID=17250719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR920402101T GR3005779T3 (enExample) | 1988-10-06 | 1992-09-24 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5051441A (enExample) |
| EP (1) | EP0363061B1 (enExample) |
| JP (1) | JPH02101065A (enExample) |
| KR (1) | KR960009570B1 (enExample) |
| CN (1) | CN1020096C (enExample) |
| AT (1) | ATE78470T1 (enExample) |
| AU (1) | AU611827B2 (enExample) |
| CA (1) | CA1330997C (enExample) |
| DE (1) | DE68902209T2 (enExample) |
| DK (1) | DK491489A (enExample) |
| ES (1) | ES2052015T3 (enExample) |
| FI (1) | FI94632C (enExample) |
| GR (1) | GR3005779T3 (enExample) |
| HK (1) | HK143095A (enExample) |
| HU (1) | HU202211B (enExample) |
| IE (1) | IE61924B1 (enExample) |
| IL (1) | IL91704A0 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL92441A (en) * | 1988-12-07 | 1993-05-13 | Tanabe Seiyaku Co | Imidazole containing peptides, their preparation and pharmaceutical compositions containing them |
| GB9020889D0 (en) * | 1990-09-25 | 1990-11-07 | May & Baker Ltd | New compositions of matter |
| JP2564380Y2 (ja) * | 1993-12-10 | 1998-03-09 | 大阪瓦斯株式会社 | 締付トルク確認継手 |
| DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
| KR100426204B1 (ko) * | 1998-05-23 | 2004-06-24 | 문승자 | 합성수지판제조방법 |
| US6365616B1 (en) | 1998-08-31 | 2002-04-02 | Sentron Medical, Inc. | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases |
| US20020142974A1 (en) * | 1998-09-11 | 2002-10-03 | Leonard D. Kohn | Immune activation by double-stranded polynucleotides |
| ES2307822T3 (es) | 2001-12-18 | 2008-12-01 | F. Hoffmann-La Roche Ag | Cis-imidazolinas como inhibidores de mdm2. |
| US7425638B2 (en) | 2003-06-17 | 2008-09-16 | Hoffmann-La Roche Inc. | Cis-imidazolines |
| ATE465729T1 (de) * | 2003-06-17 | 2010-05-15 | Hoffmann La Roche | Cis-imidazoline als mdm2-hemmer |
| US7132421B2 (en) | 2003-06-17 | 2006-11-07 | Hoffmann-La Roche Inc. | CIS-imidazoles |
| JP4814228B2 (ja) | 2004-05-18 | 2011-11-16 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ｃｉｓ−イミダゾリン |
| US7893278B2 (en) | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| EP2130822A1 (en) | 2005-12-01 | 2009-12-09 | F. Hoffmann-La Roche AG | 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents |
| WO2007082805A1 (en) | 2006-01-18 | 2007-07-26 | F. Hoffmann-La Roche Ag | Cis-4, 5-biaryl-2-heterocyclic-imidazolines as mdm2 inhibitors |
| US7625895B2 (en) | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| RU2487127C2 (ru) | 2007-10-09 | 2013-07-10 | Ф.Хоффманн-Ля Рош Аг | Хиральные цис-имидазолины |
| US8252942B2 (en) * | 2007-10-09 | 2012-08-28 | Board Of Trustees Of Michigan State University | Substituted imidazoline compounds |
| JP6447496B2 (ja) | 2014-01-29 | 2019-01-09 | 東レ株式会社 | 多発性硬化症の治療剤又は予防剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH44279A (fr) * | 1908-03-09 | 1909-07-16 | Anonima Per Frigorigeni E Moto | Appareil pour l'échange de chaleur entre des fluides sous pression |
| NL296772A (enExample) * | 1962-03-21 | |||
| GB1047569A (en) * | 1962-10-31 | 1966-11-09 | Du Pont | Light-sensitive compositions |
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| DE2960506D1 (en) * | 1978-04-24 | 1981-10-29 | Dumex Ltd As | Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them |
| US4424229A (en) * | 1979-04-23 | 1984-01-03 | A/S Dumex (Dumex Ltd.) | Fluorine containing 2,4,5-triphenylimidazoles |
| US4252887A (en) * | 1979-08-14 | 1981-02-24 | E. I. Du Pont De Nemours And Company | Dimers derived from unsymmetrical 2,4,5-triphenylimidazole compounds as photoinitiators |
| DE3141063A1 (de) * | 1981-10-13 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| GB8906198D0 (en) * | 1989-03-17 | 1989-05-04 | Ciba Geigy Ag | Compounds |
-
1988
- 1988-10-06 JP JP63253391A patent/JPH02101065A/ja active Granted
-
1989
- 1989-09-18 CA CA000611765A patent/CA1330997C/en not_active Expired - Fee Related
- 1989-09-18 IE IE297789A patent/IE61924B1/en not_active IP Right Cessation
- 1989-09-20 IL IL91704A patent/IL91704A0/xx unknown
- 1989-09-26 EP EP89309768A patent/EP0363061B1/en not_active Expired - Lifetime
- 1989-09-26 AT AT89309768T patent/ATE78470T1/de not_active IP Right Cessation
- 1989-09-26 ES ES89309768T patent/ES2052015T3/es not_active Expired - Lifetime
- 1989-09-26 DE DE8989309768T patent/DE68902209T2/de not_active Expired - Lifetime
- 1989-09-27 KR KR1019890013908A patent/KR960009570B1/ko not_active Expired - Fee Related
- 1989-09-27 CN CN89107616A patent/CN1020096C/zh not_active Expired - Fee Related
- 1989-09-29 AU AU42368/89A patent/AU611827B2/en not_active Ceased
- 1989-10-04 FI FI894693A patent/FI94632C/fi not_active IP Right Cessation
- 1989-10-04 US US07/417,199 patent/US5051441A/en not_active Expired - Fee Related
- 1989-10-05 DK DK491489A patent/DK491489A/da not_active Application Discontinuation
- 1989-10-05 HU HU895226A patent/HU202211B/hu not_active IP Right Cessation
-
1992
- 1992-09-24 GR GR920402101T patent/GR3005779T3/el unknown
-
1995
- 1995-09-07 HK HK143095A patent/HK143095A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI894693L (fi) | 1990-04-07 |
| ES2052015T3 (es) | 1994-07-01 |
| IE892977L (en) | 1990-04-06 |
| HK143095A (en) | 1995-09-15 |
| AU4236889A (en) | 1990-04-12 |
| DE68902209T2 (de) | 1992-12-10 |
| KR900006296A (ko) | 1990-05-07 |
| CN1041760A (zh) | 1990-05-02 |
| JPH02101065A (ja) | 1990-04-12 |
| US5051441A (en) | 1991-09-24 |
| KR960009570B1 (ko) | 1996-07-20 |
| IL91704A0 (en) | 1990-06-10 |
| AU611827B2 (en) | 1991-06-20 |
| FI94632C (fi) | 1995-10-10 |
| DE68902209D1 (de) | 1992-08-27 |
| HUT51601A (en) | 1990-05-28 |
| ATE78470T1 (de) | 1992-08-15 |
| FI94632B (fi) | 1995-06-30 |
| IE61924B1 (en) | 1994-11-30 |
| FI894693A0 (fi) | 1989-10-04 |
| EP0363061A1 (en) | 1990-04-11 |
| EP0363061B1 (en) | 1992-07-22 |
| HU895226D0 (en) | 1990-01-28 |
| DK491489A (da) | 1990-04-07 |
| DK491489D0 (da) | 1989-10-05 |
| CA1330997C (en) | 1994-07-26 |
| CN1020096C (zh) | 1993-03-17 |
| HU202211B (en) | 1991-02-28 |
| JPH0581592B2 (enExample) | 1993-11-15 |
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