GR3005454T3 - - Google Patents
Info
- Publication number
- GR3005454T3 GR3005454T3 GR920401275T GR920401275T GR3005454T3 GR 3005454 T3 GR3005454 T3 GR 3005454T3 GR 920401275 T GR920401275 T GR 920401275T GR 920401275 T GR920401275 T GR 920401275T GR 3005454 T3 GR3005454 T3 GR 3005454T3
- Authority
- GR
- Greece
- Prior art keywords
- agents
- injection
- isotonicising
- preparations
- urea
- Prior art date
Links
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 1
- 108090000394 Erythropoietin Proteins 0.000 abstract 1
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873729863 DE3729863A1 (de) | 1987-09-05 | 1987-09-05 | Stabilisierte erythropoietin-lyophilisate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3005454T3 true GR3005454T3 (forum.php) | 1993-05-24 |
Family
ID=6335375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR920401275T GR3005454T3 (forum.php) | 1987-09-05 | 1992-08-20 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4992419A (forum.php) |
| EP (1) | EP0306824B1 (forum.php) |
| JP (1) | JPH0780782B2 (forum.php) |
| KR (1) | KR960009929B1 (forum.php) |
| CN (1) | CN1027224C (forum.php) |
| AT (1) | ATE77556T1 (forum.php) |
| AU (1) | AU610636B2 (forum.php) |
| CA (1) | CA1330301C (forum.php) |
| CS (1) | CS274681B2 (forum.php) |
| DD (1) | DD273004A5 (forum.php) |
| DE (2) | DE3729863A1 (forum.php) |
| DK (1) | DK174811B1 (forum.php) |
| ES (1) | ES2051806T3 (forum.php) |
| FI (1) | FI93517C (forum.php) |
| GR (1) | GR3005454T3 (forum.php) |
| HK (1) | HK89495A (forum.php) |
| HU (1) | HU202761B (forum.php) |
| IE (1) | IE60310B1 (forum.php) |
| IL (1) | IL87628A (forum.php) |
| LV (1) | LV10178B (forum.php) |
| MX (1) | MX12880A (forum.php) |
| NO (1) | NO178687C (forum.php) |
| NZ (1) | NZ225975A (forum.php) |
| PH (1) | PH25618A (forum.php) |
| PL (1) | PL157944B1 (forum.php) |
| PT (1) | PT88417B (forum.php) |
| RU (2) | RU2043118C1 (forum.php) |
| UA (2) | UA26123A (forum.php) |
| ZA (1) | ZA886528B (forum.php) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| NZ232813A (en) * | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| JPH0341033A (ja) * | 1989-07-07 | 1991-02-21 | Kyowa Hakko Kogyo Co Ltd | 安定なモチリン類含有製剤 |
| DE3939346A1 (de) * | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
| DE4014654A1 (de) * | 1990-05-08 | 1991-11-14 | Behringwerke Ag | Galenische waessrige formulierungen von erythropoietin und ihre verwendung |
| DE4126983A1 (de) | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
| DE4126984A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, gut vertraeglichen arzneimitteln fuer infusions- oder injektionszwecke |
| US5912015A (en) * | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
| US20030035845A1 (en) * | 1992-06-11 | 2003-02-20 | Zale Stephen E. | Composition for sustained release of non-aggregated erythropoietin |
| US5674534A (en) * | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) * | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5661125A (en) * | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| EP0582933A1 (de) * | 1992-08-11 | 1994-02-16 | F. Hoffmann-La Roche Ag | Therapeutisches System zur parenteralen Verabreichung von hämatopoetischen Wachstumsfaktoren |
| DE4242919A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF |
| US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
| US6372716B1 (en) * | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
| JP2747979B2 (ja) * | 1994-08-19 | 1998-05-06 | 雪印乳業株式会社 | ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬 |
| IL116085A (en) * | 1994-12-16 | 1999-12-31 | Ortho Pharma Corp | Spray dried erythropoietin |
| ZA966075B (en) * | 1995-07-27 | 1998-01-19 | Genentech Inc | Protein formulation. |
| AU710347B2 (en) * | 1995-08-31 | 1999-09-16 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
| DE19539574A1 (de) * | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
| US20030138402A1 (en) * | 1995-12-25 | 2003-07-24 | Otsuka Pharmaceutical Co., Ltd. | Dry compositions |
| US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| TWI240627B (en) * | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| CZ300636B6 (cs) * | 1996-12-24 | 2009-07-08 | Biogen, Inc. | Balená souprava pro parenterální podávání interferonu-beta a kapalný farmaceutický prípravek obsahující interferon-beta |
| DE19716154A1 (de) * | 1997-04-18 | 1998-10-22 | Boehringer Mannheim Gmbh | Stabile pharmazeutische Darreichungsform für Peptide, Proteine und Nukleinsäuren |
| RU2152206C1 (ru) * | 1997-05-22 | 2000-07-10 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Таблетированная форма рекомбинантного человеческого эритропоэтина для перорального применения и способ ее получения |
| US6548296B1 (en) * | 1997-07-23 | 2003-04-15 | Roche Diagnostics Gmbh | Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof |
| US6391633B1 (en) * | 1997-07-23 | 2002-05-21 | Roche Diagnostics Gmbh | Production of erythropoietin by endogenous gene activation |
| AR019025A1 (es) * | 1998-04-09 | 2001-12-26 | Roche Diagnostics Gmbh | Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado |
| EP0965349A1 (de) * | 1998-06-18 | 1999-12-22 | Roche Diagnostics GmbH | Verwendung von Erythropoietin zur Behandlung von Hämochromatosen |
| RU2128517C1 (ru) * | 1998-07-20 | 1999-04-10 | Колобков Сергей Леонидович | Стабилизированный водный раствор эритропоэтина |
| JP2000247903A (ja) * | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
| EP1181036B1 (en) * | 1999-04-09 | 2008-07-23 | Ortho-Mcneil Pharmaceutical, Inc. | Pharmaceutical compositions of erythropoietin |
| US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| ATE389414T1 (de) * | 1999-09-08 | 2008-04-15 | Chugai Pharmaceutical Co Ltd | Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben |
| RU2182141C2 (ru) * | 2000-03-20 | 2002-05-10 | Братский государственный технический университет | Композиция для изготовления легкобетонных изделий |
| AU2005225151B2 (en) * | 2000-05-15 | 2008-05-29 | F. Hoffmann-La Roche Ag | New pharmaceutical composition |
| CZ304855B6 (cs) | 2000-05-15 | 2014-12-10 | F. Hoffmann-La Roche Ag | Kapalná farmaceutická kompozice obsahující pegylovaný lidský erythropoetin, způsob její přípravy, léčivo pro léčení chorob korelujících s anemií při chronickém renálním selhání a zařízení s jejím obsahem |
| DK1314437T3 (da) * | 2000-08-11 | 2014-07-14 | Chugai Pharmaceutical Co Ltd | Stabiliserede antistofindeholdende præparater |
| US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| RU2191594C1 (ru) * | 2001-04-03 | 2002-10-27 | Григорян Седа Суреновна | Средство и способ повышения резистентности к инфекции |
| RU2192882C1 (ru) * | 2001-04-18 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения |
| EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
| DE10149030A1 (de) | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US7425618B2 (en) * | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| SI21257A (sl) * | 2002-07-17 | 2004-02-29 | LEK farmacevtska dru�ba d.d. | Stabilni farmacevtski pripravek, ki vsebuje eritropoietin |
| DE10234192B4 (de) * | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
| US20040208869A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Uses of anti-integrin alphanubeta3 antibody formulations |
| NZ543859A (en) | 2003-06-10 | 2008-01-31 | Lg Life Sciences Ltd | Aqueous formulation that has storage stability over a long period without serum albumin comprising human erythropoietin; non-ionic surfactant, polyhydric alcohol, neutral amino acid and sugar alcohol as stabilizers |
| FR2857267B1 (fr) * | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
| KR100560697B1 (ko) * | 2003-08-06 | 2006-03-16 | 씨제이 주식회사 | 알부민을 함유하지 않는 에리스로포이에틴 제제 |
| JP2007517769A (ja) * | 2003-09-29 | 2007-07-05 | ウォーレン ファーマシューティカルズ，インコーポレーテッド | 敗血症および癒着形成の治療および予防のための組織保護性サイトカイン |
| US7141544B2 (en) * | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
| EP1537876A1 (en) * | 2003-12-01 | 2005-06-08 | BioGeneriX AG | Erythropoietin solution formulation |
| DE102004011663B4 (de) | 2004-03-10 | 2006-04-27 | Bioceuticals Arzneimittel Ag | Erythropoietin-Flüssigformulierung |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| DE102005033250A1 (de) | 2005-07-15 | 2007-01-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von G-CSF |
| KR20200000462A (ko) * | 2008-08-15 | 2020-01-02 | 아이언우드 파마슈티컬스, 인코포레이티드 | 경구 투여를 위한 리나클로타이드-함유 제형 |
| CA2770077A1 (en) * | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| DK2521561T3 (en) * | 2009-11-03 | 2017-09-11 | Ironwood Pharmaceuticals Inc | LINACLOTID FOR TREATMENT OF CHRONIC CONSTIPATION |
| EP2525779B1 (en) * | 2010-01-19 | 2018-09-05 | Hanmi Science Co., Ltd. | Liquid formulations for long-acting erythropoietin conjugate |
| US8933030B2 (en) | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| US20140005128A1 (en) | 2010-08-11 | 2014-01-02 | Forest Laboratories Holdings Limited | Treatments of gastrointestinal disorders |
| EP2776055B1 (en) | 2011-08-17 | 2016-12-14 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| EA022327B1 (ru) * | 2013-01-04 | 2015-12-30 | Общество С Ограниченной Ответственностью "Рубикон" | Инъекционное ветеринарное средство в форме раствора для борьбы с полиинвазиями животного и способ его получения |
| EP3125922B1 (en) | 2014-03-29 | 2020-10-14 | Intas Pharmaceuticals Limited | Liquid pharmaceutical composition of conjugated erythropoietin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865801A (en) * | 1973-06-15 | 1975-02-11 | Atomic Energy Commission | Stabilization of urinary erythropoietin using sodium p-aminosalicylate and extracting into phenol |
| JPS6197229A (ja) * | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| EP0214281B1 (en) * | 1985-03-06 | 1992-09-09 | Survival Technology, Inc. | Protein absorption enhancing agents |
-
1987
- 1987-09-05 DE DE19873729863 patent/DE3729863A1/de not_active Withdrawn
-
1988
- 1988-08-30 NZ NZ225975A patent/NZ225975A/en unknown
- 1988-08-30 DD DD88319317A patent/DD273004A5/de unknown
- 1988-08-30 DK DK198804831A patent/DK174811B1/da active
- 1988-08-31 MX MX1288088A patent/MX12880A/es unknown
- 1988-08-31 IL IL87628A patent/IL87628A/xx not_active IP Right Cessation
- 1988-09-01 DE DE8888114246T patent/DE3872334D1/de not_active Expired - Lifetime
- 1988-09-01 US US07/240,005 patent/US4992419A/en not_active Expired - Lifetime
- 1988-09-01 PL PL1988274485A patent/PL157944B1/pl unknown
- 1988-09-01 ES ES88114246T patent/ES2051806T3/es not_active Expired - Lifetime
- 1988-09-01 AT AT88114246T patent/ATE77556T1/de not_active IP Right Cessation
- 1988-09-01 CS CS590188A patent/CS274681B2/cs not_active IP Right Cessation
- 1988-09-01 EP EP88114246A patent/EP0306824B1/de not_active Expired - Lifetime
- 1988-09-02 IE IE267188A patent/IE60310B1/en not_active IP Right Cessation
- 1988-09-02 ZA ZA886528A patent/ZA886528B/xx unknown
- 1988-09-02 FI FI884051A patent/FI93517C/fi not_active IP Right Cessation
- 1988-09-02 PH PH37498A patent/PH25618A/en unknown
- 1988-09-02 PT PT88417A patent/PT88417B/pt not_active IP Right Cessation
- 1988-09-02 NO NO883926A patent/NO178687C/no not_active IP Right Cessation
- 1988-09-02 HU HU884536A patent/HU202761B/hu unknown
- 1988-09-02 CA CA000577075A patent/CA1330301C/en not_active Expired - Lifetime
- 1988-09-02 AU AU21739/88A patent/AU610636B2/en not_active Expired
- 1988-09-05 RU SU884356379A patent/RU2043118C1/ru active
- 1988-09-05 UA UA4356379A patent/UA26123A/uk unknown
- 1988-09-05 JP JP63220591A patent/JPH0780782B2/ja not_active Expired - Lifetime
- 1988-09-05 KR KR1019880011488A patent/KR960009929B1/ko not_active Expired - Lifetime
- 1988-09-05 UA UA5010234A patent/UA26855C2/uk unknown
- 1988-09-05 CN CN88106464A patent/CN1027224C/zh not_active Expired - Lifetime
-
1991
- 1991-12-02 RU SU915010234A patent/RU2100032C1/ru active
-
1992
- 1992-08-20 GR GR920401275T patent/GR3005454T3/el unknown
-
1993
- 1993-06-02 LV LVP-93-470A patent/LV10178B/lv unknown
-
1995
- 1995-06-08 HK HK89495A patent/HK89495A/xx not_active IP Right Cessation
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