GR3004980T3 - - Google Patents

Info

Publication number
GR3004980T3
GR3004980T3 GR920401315T GR920401315T GR3004980T3 GR 3004980 T3 GR3004980 T3 GR 3004980T3 GR 920401315 T GR920401315 T GR 920401315T GR 920401315 T GR920401315 T GR 920401315T GR 3004980 T3 GR3004980 T3 GR 3004980T3
Authority
GR
Greece
Prior art keywords
compounds
hydroxy
methylation
keto
chem
Prior art date
Application number
GR920401315T
Other languages
Greek (el)
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3004980T3 publication Critical patent/GR3004980T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR920401315T 1987-10-20 1992-06-18 GR3004980T3 (enEXAMPLES)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22343/87A IT1223313B (it) 1987-10-20 1987-10-20 Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
GR3004980T3 true GR3004980T3 (enEXAMPLES) 1993-04-28

Family

ID=11194953

Family Applications (2)

Application Number Title Priority Date Filing Date
GR89300125T GR890300125T1 (en) 1987-10-20 1990-01-31 Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them
GR920401315T GR3004980T3 (enEXAMPLES) 1987-10-20 1992-06-18

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GR89300125T GR890300125T1 (en) 1987-10-20 1990-01-31 Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them

Country Status (8)

Country Link
US (1) US4921848A (enEXAMPLES)
EP (1) EP0312867B1 (enEXAMPLES)
JP (1) JP2813610B2 (enEXAMPLES)
AT (1) ATE75750T1 (enEXAMPLES)
DE (2) DE312867T1 (enEXAMPLES)
ES (1) ES2009723T3 (enEXAMPLES)
GR (2) GR890300125T1 (enEXAMPLES)
IT (1) IT1223313B (enEXAMPLES)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229569B (it) * 1989-04-17 1991-09-04 Giuliani Spa Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
US5650967A (en) * 1995-07-06 1997-07-22 Micron Technology, Inc. Method and apparatus for writing and erasing flash memory
JP2002526193A (ja) * 1998-09-18 2002-08-20 ユナイテッド ステイツ サージカル コーポレーション 脈管内ファスナーアプリケータ
CA2440680C (en) 2001-03-12 2010-06-01 Roberto Pellicciari Steroids as agonists for fxr
ITMI20021532A1 (it) * 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
EP1562915A1 (en) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Farnesoid x receptor agonists
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
DK2712617T3 (en) 2004-03-12 2017-02-13 Intercept Pharmaceuticals Inc Treatment of fibrosis with Fxr ligands.
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
MX2009007728A (es) * 2007-01-19 2009-12-15 Intercept Pharmaceuticals Inc Acidos biliares 23-sustituidos como moduladores de tgr5 y metodos de uso de los mismos.
WO2010014836A2 (en) 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
PL2698375T3 (pl) 2008-11-19 2018-08-31 Intercept Pharmaceuticals, Inc. Modulatory TGR5 i sposób ich zastosowania
BR112014031828B1 (pt) 2012-06-19 2021-12-21 Intercept Pharmaceuticals, Inc Composições farmacêuticas compreendendo a forma 1 de ácido obeticólico
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
EP3006557A1 (en) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Bile acids for inducing hepatic differentiation
TN2018000106A1 (en) 2015-10-07 2019-10-04 Intercept Pharmaceuticals Inc Farnesoid x receptor modulators
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN107033208A (zh) * 2017-04-07 2017-08-11 华东师范大学 一种7‑酮基石胆酸的合成方法
CN107021994B (zh) * 2017-04-07 2020-12-22 华东师范大学 一种奥贝胆酸的中间体3α-羟基-7-酮-5β-胆甾烷-24-酸的合成方法
CN106995478A (zh) * 2017-04-07 2017-08-01 华东师范大学 一种熊去氧胆酸的中间体7‑酮基石胆酸的合成方法
CN106939030A (zh) * 2017-04-07 2017-07-11 华东师范大学 一种奥贝胆酸的中间体7‑酮基石胆酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2615902A (en) * 1950-10-24 1952-10-28 Merck & Co Inc Chemical compounds and processes for preparing the same
US2966499A (en) * 1958-04-09 1960-12-27 Merck & Co Inc Oxidation of cholic acid with chlorine
US2938031A (en) * 1958-12-11 1960-05-24 Searle & Co 17-carboxyalkylated 3-oxygenated 6-methylandrosten-17-ol lactones and intermediates
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
US4172076A (en) * 1977-04-04 1979-10-23 Diamond Shamrock Corporation Process for preparing steroidal acids and their intermediate derivatives
US4460509A (en) 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis
US4648995A (en) 1983-11-02 1987-03-10 Beth Israel Medical Center Chemical synthesis
US4545938A (en) 1983-11-02 1985-10-08 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
DE3870801D1 (de) 1992-06-11
GR890300125T1 (en) 1990-01-31
DE312867T1 (de) 1989-10-05
EP0312867A1 (en) 1989-04-26
EP0312867B1 (en) 1992-05-06
JPH01135795A (ja) 1989-05-29
JP2813610B2 (ja) 1998-10-22
ATE75750T1 (de) 1992-05-15
IT8722343A0 (it) 1987-10-20
ES2009723T3 (es) 1993-02-16
ES2009723A4 (es) 1989-10-16
IT1223313B (it) 1990-09-19
US4921848A (en) 1990-05-01

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